Floralozone is one of several aroma compounds that evoke a perception known as “aquatic”, “watery”, “ozone”, “muguet”, “rhubarb”, etc. Other compounds that evoke such a perceptual note include cyclamen aldehyde, calone (watermelon ketone), lyral, bourgeonal, lilial, 1-decanol, and 1-dodecanol. Some of the strongest agonists of OR1D2 have this note, though not all OR1D2 agonists do. […]
Read MoreOlfactory receptors (ORs), being G-protein coupled receptors (GPCRs), exist in an equilibrium between several conformational states. Most of the time, the dominant conformation is the inactive state, which cannot bind a G-protein and signal the cell to the presence of an odorant, while a certain other conformation can bind a G-protein and initiate this signaling, […]
Read MoreAccording to an article by Cheng et al (2010), figure 1, there exist several pathways for GPCR signaling following receptor activation. One of these involves cAMP while another involves Ca²⁺. However, there is the potential for false positives by this method, as well as false negatives because a given receptor or receptor-ligand pair might bind […]
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