Subjects with two copies of a mutated version of the OR5A1 receptor report the smell of β-ionone as vinegar-like instead of floral. The overall sensitivity to this compound is also reduced. We have used these facts to assign the floral perceptual note to OR5A1. However, the mutation is at position 183 in one of the […]
Read MoreOR5A1 has one known agonist, β-ionone, which has a distinctive floral violet tart dry woody fruity berry aroma. By itself, this would not be enough information to assign one aroma note to the receptor, but it has been found that a polymorphism on the OR5A1 gene causes individuals with two variant copies to perceive β-ionone […]
Read MoreTo characterize the contributions of single olfactory receptors (ORs) to the perception of aromas, mixtures were prepared of agonists for individual ORs and smelled. The hypothesis is that the various aroma chemicals will dilute each other’s effect on ORs other than the target receptor, leaving a mixture that smells mostly like the target receptor’s contribution. […]
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