• 2022-08-02
  • N/A

OR activation might involve a conserved glutamate residue.

This dock of d-limonene in OR2B11 shows Tyr256 displaced “down” (i.e. in the cytoplasmic direction) from its pre-dock position (transparent image, lowercase label) near a position of forming a hydrogen bond with Glu115. Tyr256 is in an analogous location to the known highly conserved Trp6.48 important to activation of non-OR GPCRs. Almost all ORs have […]

computation
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