This is a dock result of allyl phenylacetate in a predicted active conformation of OR1A1. The active model was generated by applying internal contact changes similar to those known for OR51E2, mTAAR9, and non-olfactory GPCRs. This dock shows the aromatic ring of the ligand in a pi stacking position between two of the receptor’s aromatic […]
Read MoreThese images list some of the ORs that are known to respond to each aroma, and which perceptual notes have been assigned to them. Lemon image by Ben Landers from Pixabay.Cinnamon image by Steve Buissinne from Pixabay.Clove image by abuyotam from Pixabay.Vanilla image by Lukas from Pexels.Caraway image by David Mark from Pixabay.
Read MoreVeithen et al (2015), writing about OR1D2’s broadly tuned agonist spectrum, claim that “the different agonists are not linked by a common organoleptic characteristic or note.” Here we present evidence, in the form of a differential experiment, to refute that statement. The following mixtures were prepared: 1.) tetrahydromyrcenol 0.6g, bourgeonal 15% in EtOH 0.9g, floralozone […]
Read MoreAfter finding that OR51E1 agonists have a cheesy note, the author has targeted three more receptors with agonist/antagonist differential experiments. For OR2A25, the aroma of unmixed geranyl acetate was compared with that of the same compound mixed with methyl salicylate. Geranyl acetate is an agonist for OR2A25. Methyl salicylate is an antagonist for this receptor, […]
Read MoreOR51E1 is a receptor for fatty acids with 3-10 carbon atoms, particularly those with cheesy or sweaty perceptual notes. But this receptor is also sensitive to methyl eugenol, methyl salicylate, and menthol, none of which smell cheesy or sweaty. Previously it was hypothesized on the PrimaryOdors website that OR51E1 must encode a milky quality, since […]
Read MoreThe Primary Odors docker, or POdock, is an open source molecular docker designed to offer advantages over other dockers. Here we report a successful dock of the aroma compound cadaverine in TAAR8, a known agonist-receptor pair. The change in orientation of the TRP270 side chain is significant. This residue, and the aromatic TYR273 above it, […]
Read MoreUsing the new POdock software, we have obtained promising initial results indicating that the changes in binding strengths along a path may be good predictors of which ligands will activate a given receptor. POdock offers a feature not commonly found in docking software, which is the ability to move each generated pose along a path […]
Read MoreThe author is unusually sensitive to myrac aldehyde (also known as Empetal) and perceives in it an intense milky aroma. Other individuals do not seem to share this perception, or at least not to the same degree. Myrac aldehyde is a precursor to the production of lyral, and the two molecules differ very little in […]
Read MoreThere’s a perceptual aroma note, common to such aroma characters as berry, wine, grape, plum, geranium, anise, and clove, that can only be described as “purple”. It appears to make up part of the two candidate primaries referred to on this website as jammy and xyloenanthic. “Purple” smelling aroma molecules are disproportionately associated with the […]
Read MoreThe agonist mixtures for OR2W1 reveal a perceptual note best described as “stale”, that seems to be enhanced by the presence of OR1A1 agonists or OR2J2 agonists. 2W1 is highly sensitive to geraniol and citronellol, both of which have a certain fetid-vegetable note that’s very noticeable in the aromas of geranium oil and citronella oil, […]
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