Some of the known ligands for OR1A1 have been processed by the automated server, under the assumption that the EXR2 domain includes a zinc binding site, and that this zinc ion participates in odorant detection. Preliminary results have been obtained, consisting of correlation coefficients and p values for a number of metrics of OR perturbation […]
Read MoreVideo shows predicted binding of human OR1A1 to allyl phenylacetate, assuming a zinc binding site consisting of ASN176, CYS179, and ASP180.
Read MoreIt has been known for a long time that zinc is necessary for olfaction in humans, that zinc deficiency reversibly causes anosmia, and that too much zinc can cause permanent anosmia, as can cadmium, a very toxic analog of zinc. Research has been done into the role of metals in mammalian olfaction; one study identified […]
Read MoreThis stereogram depicts predicted binding geometry of cinnamaldehyde and the putative functional side chains of hOR1G1. This odorant is a known ligand of this receptor. Other known ligands of this OR are compounds that generally have a waxy, fatty, rosy, or fresh note to their perceptual aromas.
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