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Olfactory Receptor family 10 subfamily J member 5.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MKRKNFTEVS EFIFLGFSSF GKHQITLFVV FLTVYILTLV ANIIIVTIIC IDHHLHTPMY FFLSMLASSE TVYTLVIVPR MLLSLIFHNQ PISLAGCATQ 

       110        120        130        140        150        160        170        180        190        200 
MFFFVILATN NCFLLTAMGY DRYVAICRPL RYTVIMSKGL CAQLVCGSFG IGLTMAVLHV TAMFNLPFCG TVVDHFFCDI YPVMKLSCID TTINEIINYG 

       210        220        230        240        250        260        270        280        290        300 
VSSFVIFVPI GLIFISYVLV ISSILQIASA EGRKKTFATC VSHLTVVIVH CGCASIAYLK PKSESSIEKD LVLSVTYTII TPLLNPVVYS LRNKEVKDAL 

       310 
CRVVGRNIS

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

H K G F      I L  G A L S       A   I T T D       K   K E I S  
 T I Q    S L L    T A C   T V H L   I E N   L Y A I   V L D   
V V F L  M R P V  F F M Q   V A M   G Y N I   S A C   T V S L  
 T L F    I V L    I V F   T L G I   S S V   G C H V   I T Y   
L I Y V  T Y V T  N T A L   G F S   F I V F   I V V   L P T I  
 V L T    E S S    F C N   G C V L   I P V   T L H S   P N L   
I I N A  A L M S  A T L L   Q A C   F I L G   V C T   S Y V V  
 T V I    L F F    Y G M   L G K S   Y S I   A F T K       L   
  C I I  Y M P T  V Y R D           I V L V   K R G            
                   C I A             I S S   E A S A           
                        R               Q L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
lyral -5.14 1 10 2  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
alpha-cedrene - 8.125 2  cedar, fresh, sweet, woody
bourgeonal -3.05 3 7.5 3  cyclamen, floral, fresh, sweet, watery
acetophenone - 0 4  sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
aldehyde C-10 - 0 5  aldehydic, citrus, floral, orange, peel, sweet, waxy
aldehyde C-8 - 0 4  aldehydic, citrus, fatty, green, orange, peel, waxy
aldehyde C-9 - 0 5  aldehydic, fatty, fresh, orange, orris, peel, peely, rose, waxy
allyl heptanoate - 0 4  banana, cognac, fruity, fusel, pineapple, sweet, waxy
allyl phenylacetate - 0 5  fruity, honey, rummy
allylbenzene - 0 4  
amyl hexanoate - 0 5  apple, estery, fatty, fruity, green, pear, pineapple, sweet
androstenone - 0 5  animal, musky
l-arabinose - 0 5  
benzene - 0 5  
benzophenone - 0 4  balsamic, geranium, herbal, metallic, powdery, rose
benzyl acetate - 0 4  floral, fresh, fruity, jasmine, sweet
butyl butyryl lactate - 0 4  buttermilk, buttery, cheesy, creamy, dairy
butyl formate - 0 5  brandy, fruity, plum, rummy
butyric acid - 0 5  acetic, buttery, cheesy, fruity, sharp
(-)-camphor - 0 4  
camphor - 0 4  camphoraceous
capric acid - 0 4  citrus, fatty, rancid, sour
caproic acid - 0 4  cheesy, fatty, sour, sweaty
gamma-caprolactone - 0 4  coconut, coumarinic, herbal, sweet, tobacco
caprylic acid - 0 4  cheesy, fatty, oily, rancid, vegetable, waxy
caramel furanone - 0 5  burnt, caramellic, coffee, maple, sugar, sweet
(R)-(-)-carvone - 0 4  herbal, minty, spearmint, sweet
(S)-(+)-carvone - 0 5  bready, caraway, minty, spicy
4-chromanone - 0 4  
citral - 0 5  citrus, lemon, sharp, sweet
(S)-(-)-citronellol - 0 4  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
coffee difuran - 0 5  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
2-coumaranone - 0 4  
coumarin - 0 5  coumarinic, hay, sweet, tonka
cyclohexanone - 0 4  acetone, minty
beta-damascone - 0 5  berry, currant, floral, fruity, honey, plum, rose, tobacco
1-decanol - 0 4  aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
(+)-dihydrocarvone - 0 4  herbal, mentholic, minty
dihydrojasmone - 0 4  floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody
dimethyl disulfide - 0 5  cabbage, onion, sulfurous, vegetable
2,4-DNT - 0 5  
2-ethyl fenchol - 0 5  camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl isobutyrate - 0 4  alcoholic, ethereal, fruity, fusel, rummy, sweet
ethyl vanillin - 0 5  caramellic, creamy, sweet, vanilla
eugenol - 0 5  clove, spicy, sweet, woody
eugenyl acetate - 0 5  carnation, clove, floral, fresh, malty, spicy, sweet, woody
fenchone - 0 4  camphoraceous, earthy, herbal, woody
geraniol - 0 4  citrus, floral, fruity, rose, sweet, waxy
geranyl acetate - 0 5  floral, green, lavender, rose, waxy
helional - 0 5  cyclamen, fresh, green, hay, ozone, watery
heptanal - 0 4  aldehydic, cognac, fatty, fresh, green, herbal, ozone
1-heptanol - 0 4  apple, banana, fruity, green, herbal, leafy, musty, peony, pungent, sweet, vegetable, violet, woody
2-heptanone - 0 5  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
3-heptanone - 0 4  fatty, fruity, green
hexanal - 0 4  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
2,3-hexanedione - 0 4  buttery, sweet
3,4-hexanedione - 0 4  almond, buttery, caramellic, nutty, toasted
1-hexanol - 0 4  alcoholic, ethereal, fruity, fusel, green, herbal, oily, pungent, sweet
2-hexanone - 0 4  ethereal
cis-3-hexen-1-ol - 0 5  foliage, fresh, grassy, green, herbal, oily, vegetable
hexyl acetate - 0 4  apple, banana, fruity, green, sweet
4-hydroxycoumarin - 0 4  
isobutylamine - 0 5  cheesy, fishy
d-limonene - 0 5  citrus, fresh, orange, sweet
linalool - 0 5  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
(+)-menthol - 0 5  cooling, mentholic, minty
methyl eugenol - 0 5  carnation, cinnamon, clove, fresh, spicy, sweet, warm
methyl furfuryl disulfide - 0 5  alliaceous, coffee, meaty, roasted, sulfurous
methyl salicylate - 0 5  minty, wintergreen
nonanethiol - 0 4  
1-nonanol - 0 4  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
2-nonanone - 0 4  earthy, fresh, fruity, green, herbal, sweet, weedy
octanethiol - 0 5  sulfurous
1-octanol - 0 5  aldehydic, green, mushroom, orange, rose, waxy
2-octanone - 0 4  earthy, herbal, natural, weedy, woody
3-octanone - 0 4  fresh, herbal, lavender, mushroom, sweet
octyl octanoate - 0 5  coconut, fruity, oily
oenanthic acid - 0 4  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
pelargonic acid - 0 5  cheesy, dairy, dirty, waxy
pentanol - 0 5  balsamic, fermented, fusel, oily, sweet
2-pentanone - 0 4  banana, ethereal, fruity, sweet, winey, woody
phenyl acetate - 0 4  animal, burnt, castoreum, medicinal, phenolic, resinous, smoky, woody
(+)-2-phenylbutyric acid - 0 4  
prenyl acetate - 0 4  balsamic, banana, fresh, fruity, heliotrope, jasmine, ripe, sweet
propanal - 0 5  alcoholic, cocoa, earthy, nutty, whiskey, winey
propionic acid - 0 5  acidic, cheesy, pungent, vinegar
pyrazine - 0 5  pungent, sweet, corn, roasted, hazelnut, barley
quinoline - 0 5  earthy, medicinal, musty, rubbery, tobacco
terpinyl acetate - 0 5  bergamot, citrus, herbal, lavender, lime
valeric acid - 0 4  acidic, cheesy, fruity, milky, sharp, sour, tobacco
vanillic acid - 0 4  beany, brown, creamy, dairy, milky, phenolic, powdery, sweet, vanilla

1.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

2.) Tong, T., Ryu, S., Min, Y. et al. Olfactory receptor 10J5 responding to α-cedrene regulates hepatic steatosis via the cAMP–PKA pathway. Sci Rep 7, 9471 (2017).

3.) C. Trimmer, A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland Genetic variation across the human olfactory receptor repertoire alters odor perception PNAS | May 7, 2019 | vol. 116 | no. 19 | 9475–9480

4.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

5.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821