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Olfactory Receptor family 2 subfamily AT member 4.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MDATACNESV DGSPVFYLLG IPSLPETFFL PVFFIFLLFY LLILMGNALI LVAVVAEPSL HKPMYFFLIN LSTLDILFTT TTVPKMLSLF LLGDRFLSFS 

       110        120        130        140        150        160        170        180        190        200 
SCLLQMYLFQ SFTCSEAFIL VVMAYDRYVA ICHPLHYPVL MNPQTNATLA ASAWLTALLL PIPAVVRTSQ MAYNSIAYIY HCFCDHLAVV QASCSDTTPQ 

       210        220        230        240        250        260        270        280        290        300 
TLMGFCIAMV VSFLPLLLVL LSYVHILASV LRISSLEGRA KAFSTCSSHL LVVGTYYSSI AIAYVAYRAD LPLDFHIMGN VVYAILTPIL NPLIYTLRNR 

       310        320 
DVKAAITKIM SQDPGCDRSI

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

F T E P      L F  S F S L     R V   T T D S     A V   D L P L  
 P L F    L S L    L C S   V A P I   T Q P   Y A I A   I H F   
I F F V  M K P V  Y M Q L   P L L   F G M L   I S S   V N G M  
 L L F    T T T    Q F L   L A T L   A I C   Y Y T G   A Y V   
L L Y F  T F L I  C T F S   W A S   S V V M   V V L   P T L I  
 M L I    D L T    A E S   A A L T   P L F   L H S S   N L I   
L A N G  S L N I  V L I F   A N T   V L L L   C T S   Y I L P  
 V L I    L F F    A M V   Q P N M   S L L   F A K A       T   
  V V A  Y M P K  Y R D Y           I H V Y   R G E            
                   I A V             S A L   L S S I           
                        C               L V                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
sandalore -4.6 1 10 1  sandalwood, woody, waxy, greasy, creamy, cedar
brahmanol -4.3 1 5 1  sandalwood, waxy, woody, herbal, nutty
isoeugenol -5 2 0.5254 2  carnation, clove, floral, spicy, sweet, woody
sandranol -4.7 1 0.25 1  woody, sandalwood, greasy, oily, waxy
javanol - 1.25 1  tropical, woody, fatty, sandalwood, herbal, cologne, floral
ebanol - 0 1  
isobornyl cyclohexanol - 0 1  sandalwood, clean, sweet, woody
phenirate - 0 1 Yfloral, fruity, honey, rose, sweet, tropical, waxy
polysantol - 0 1  
raspberry ketone - 0 1 Yberry, floral, jammy, raspberry, ripe, seedy, sweet, woody
alpha-santalol - 0 1  woody, sandalwood
beta-santalol - 0 1  woody

1.) D. Busse, P. Kudella, N.-M. Gruning, G. Gisselmann, S. Stander, T. Luger, F. Jacobsen, L. Steinstraser, R. Paus, P. Gkogkolou et al, A Synthetic Sandalwood Odorant Induces Wound-Healing Processes in Human Keratinocytes via the Olfactory Receptor OR2AT4, J. Invest. Dermatol. 134 (2014) 2823-2832.

2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.