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Olfactory Receptor family 5 subfamily M member 3.

Estimated Expression: 92% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MLNFTDVTEF ILLGLTSRRE WQVLFFIIFL VVYIITMVGN IGMMVLIKVS PQLNNPMYFF LSHLSFVDVW FSSNVTPKML ENLLSDKKTI TYAGCLVQCF 

       110        120        130        140        150        160        170        180        190        200 
FFIALVHVEI FILAAMAFDR YMAIGNPLLY GSKMSRVVCI RLITFPYIYG FLTSLAATLW TYGLYFCGKI EINHFYCADP PLIKMACAGT FVKEYTMIIL 

       210        220        230        240        250        260        270        280        290        300 
AGINFTYSLT VIIISYLFIL IAILRMRSAE GRQKAFSTCG SHLTAVIIFY GTLIFMYLRR PTEESVEQGK MVAVFYTTVI PMLNPMIYSL RNKDVKKAMM 

       310 
KVISRSC

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

Q E V S     R R   V F T G     T W   I T K K      L L  W E R R  
 M K G   L Y M F   Y E K   L T A A   A Y T    N E L    L V Q   
F V A V   I L T   I I M T   L S T   V L C G  M K P T  I I F F  
 T T Y   G Y F I   G A L   L F G Y   F C Q    V N S    V L F   
M P I V   I V A   T F N I   I Y P   A I F F  S F W V  I I Y V  
 P N L   T L H S   L S Y   F T I L   H V L    D V F    V M T   
    I M   G C T   I I V T   R I C   F I E V  S L H S  G I N G  
         S F A K   Y S I   V V R S   A L I    L F F    V M M   
          Q R G   L I F L           F A M A  Y M P N  V K I L  
         E A S R   I A I             Y R D                 S   
                    M R L           G I A M                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
ethyl maltol -4.95 1 -  sweet, sugar, caramellic, jammy, strawberry, cotton_candy, berry
ethylcyclotene -4.58 1 -  sweet, caramellic, maple, fenugreek, brown_sugar, rummy, whisky
coronol -4.32 1 -  caramel, nut
4-methyl corylone -4.32 1 -  burnt_sugar, roasty, spicy, nutty
maltol -4.15 1 -  sweet, caramellic, cotton_candy, jammy, fruity, bread, baked
cyclotene hydrate -3.92 1 -  caramellic, maple
maltyl isobutyrate -3.91 1 -  berry, caramellic, cotton_candy, fruity, strawberry, sweet, tropical
sotolone -3.34 1 -  sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
furaneol -5.20 1 1.75 1  sweet, cotton_candy, caramellic, strawberry, brown_sugar
homofuraneol -5.31 1 1.5 1  sweet, cotton_candy, burnt_sugar, sugar, caramellic, bready
hexanal - 0.5 2  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
2,2-dimethyl-3(2h)-furanone - 0 3  sweet, rotten_fruit
2,5-dimethyl-3(2h)-furanone - 0 3  green, bell_pepper
3-methyl-2(5h)-furanone - 0 3  metallic, solvent

1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

2.) Ojiro I, Katsuyama H, Kaneko R, Ogasawara S, Murata T, Terada Y, et al. (2024) Enhancement of transcription efficiency by TAR-Tat system increases the functional expression of human olfactory receptors. PLoS ONE 19(6): e0306029. https://doi.org/10.1371/journal.pone.0306029

3.) HAAG, Franziska, HOFFMANN, Sandra, et KRAUTWURST, Dietmar. Key Food Furanones Furaneol and Sotolone Specifically Activate Distinct Odorant Receptors. Journal of Agricultural and Food Chemistry, 2021, vol. 69, no 37, p. 10999-11005.
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