OR6C70

Olfactory Receptor family 6 subfamily C member 70.

Estimated Expression: 92% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MKNHTRQIEF ILLGLTDNSQ LQIVIFLFLL LNCVLSMIGN FTIIALILLD SQLKTPMYFF LRNFSFLEIS FTTACIPRFL ITIVTREKTI SCNGCISQLF 

       110        120        130        140        150        160        170        180        190        200 
FYIFLGVTEF FLLAALSYDR YVAICKPLRY MSIMSNKVCY QLVFSSWVTG FLIIFTPLIL GLNLDFCASN IIDHFICDIS LILQLSCSDT HLLELIAFLL 

       210        220        230        240        250        260        270        280        290        300 
AVMTLIVTLF LVILSYSYII KTILKFPSAQ QKKKAFSTCS SHMIVVSITY GSCMFIYIKP SANERVALSK GVTVLNTSVA PLLNPFIYTL RNQQVKQAFK 

       310        320 
AVFRKIFSAS DK

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


S L A V       P   L H T D     G L   S I T K      V I  L Q S N  
 V G K   K I Y I   L E L   I L P T   G N C    T I L    V I Q   
N L V T   F M C   L F A I   F I I   Q S I C  F R P I  F L F I  
 V S T   S G Y T   V A L   L F G T   F F L    C A T    L L L   
L L P A   I S V   I L T M   V W S   L F I Y  T F S I  L V C N  
 F P N   V I M H   L T V   S F V L   T V G    E L F    I M S   
  T Y I   S S C   I V L F   Q Y C   L F F E  S F N R  T F N G  
         T S F A   Y S L   V K N S   A A L    L F F    A I I   
          K K K   I I Y S           D Y S L  Y M P T  L L I L  
         Q Q A S   I T K             V Y R                 D   
                    F K L           K C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards

Odorant	EC₅₀	Adjusted Top	Antagonist?	Aroma Notes
(E)-anethole	-	10 ¹		sweet, anise, licorice, mimosa, medicinal, spicy

1.) Gisladottir, R. S., Ivarsdottir, E. V., Helgason, A., Jonsson, L., Hannesdottir, N. K., Rutsdottir, G., ... & Stefansson, K. (2020). Sequence variants in TAAR5 and other loci affect human odor perception and naming. Current Biology, 30(23), 4643-4653.

Prot.	Sim.	Expr.	2.53	3.29	3.32	3.33	3.36	3.37	3.40	3.41	4.53	4.56	4.57	4.60	45.49	45.51	45.52	45.53	5.39	5.42	5.43	5.46	5.47	6.48	6.51	6.55	6.59	7.38	7.39	7.41	7.42
OR6C70	100	92%	F	L	Y	I	G	V	F	F	G	I	I	P	I	D	I	S	A	L	A	T	L	Y	C	Y	S	T	V	N	T
OR6C75	92	76%	F	L	F	I	G	V	F	Y	G	I	I	P	I	D	S	S	A	L	A	T	L	Y	C	Y	S	A	V	N	T
OR6C74	89	57%	F	L	T	I	G	A	F	F	G	I	I	P	F	D	V	S	M	S	A	T	L	Y	C	Y	S	A	L	S	T
OR6C2	87	100%	F	I	V	I	G	A	F	F	G	I	I	P	S	D	A	G	V	M	A	A	L	Y	C	Y	S	S	V	T	T
OR6C65	86	11%	F	V	L	I	G	S	F	F	G	I	I	P	I	D	S	S	A	L	A	T	L	Y	C	C	S	A	V	N	T
OR6C3	86	73%	F	L	F	I	G	V	F	Y	G	T	I	P	A	D	Y	F	G	F	A	T	L	Y	C	Y	S	A	I	N	T
OR6C6	85	65%	F	L	I	L	G	V	F	Y	G	I	I	P	M	E	T	S	S	L	A	T	L	Y	C	Y	S	A	L	Y	T
OR6C4	84	92%	F	Y	A	I	G	A	F	Y	G	A	I	P	Y	D	Y	G	V	L	A	T	L	Y	C	Y	S	A	V	I	T
OR2AP1	83		F	Y	A	M	G	A	F	Y	G	A	I	T	F	D	Y	E	V	V	A	T	L	Y	C	Y	S	A	L	I	T
OR6C68	83	38%	F	L	A	D	G	V	F	F	A	I	I	P	G	D	A	L	V	S	A	T	F	Y	C	Y	S	S	V	I	S
OR6C1	82	92%	F	L	F	I	G	V	F	Y	S	I	I	A	T	D	Y	F	G	C	A	T	L	Y	C	Y	S	A	I	N	T
OR8B2	80	88%	Y	L	F	L	V	I	C	Y	G	G	A	H	L	D	I	L	V	V	V	N	I	F	A	Y	Y	S	V	Y	T
OR8B3	80	88%	Y	L	F	L	V	I	C	Y	G	G	A	H	L	D	I	L	V	V	V	N	I	F	A	Y	Y	S	V	Y	T
OR6F1	80	100%	Y	M	V	F	G	C	Y	F	G	A	I	P	F	D	I	A	A	I	A	V	I	Y	T	H	S	H	V	N	T

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