Olfactory Receptor family 10 subfamily H member 1.
Estimated Expression: 100% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MQRANHSTVT QFILVGFSVF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW SERSLHTPMY LFLCALSVSE ILYTVAIIPR MLADLLSTQR SIAFLACASQ 110 120 130 140 150 160 170 180 190 200 MFFSFSFGFT HSFLLTVMGY DRYVAICHPL RYNVLMSPRG CACLVGCSWA GGLVMGMVVT SAIFHLAFCG HKEIHHFACH VPPLLKLACG DDVLVVAKGV 210 220 230 240 250 260 270 280 290 300 GLVCITALLG CFLLILLSYA FIVAAILKIP SAEGRNKAFS TCASHLTVVV VHYGFASVIY LKPKSPQSLE GDTLMGITYT VLTPFLSPII FSLRNKELKV 310 320 AMKKTFFSKL YPEKNVMM
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 G E L S K V L V D I A I S R Q L L L H P F L T D L Y I V K A V S T V V L F A D A L M L Q T I G M S A F L G V G M G M S A C A M R P I L L F L V T Y G Y H V I C V V L G G F M Q I A V L L F F P T L V V V L L A T A W S S F S F T Y L I F L Y M P S L T L H S F C G C G V L F G F E S V L L T F I I A C T L I L L C A C F S H T S L A C L L N G S F A K Y S L G R P S T L L L F L A M I N R G V I F A Y G M V Y M P T S W V T E A S P I A A Y R D E I K L C I A V UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB 2
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| sandranol | -5.15 1 | 10 1 | woody, sandalwood, greasy, oily, waxy | |
| azurone | -5.15 2 | (agonist) 2 | marine | |
| benzene | -1.66 3 | 0.0692 3 | gasoline, phenolic, solvent, cinnamon | |
| acetophenone | -1.6 3 | 0.1064 3 | sweet, pungent, hawthorn, mimosa, almond, acacia, chemical | |
| heptanal | - | 0 4 | aldehydic, cognac, fatty, fresh, green, herbal, ozone |
1.) Weber, Lea et al. “Characterization of the Olfactory Receptor OR10H1 in Human Urinary Bladder Cancer.” Frontiers in physiology vol. 9 456. 16 May. 2018, doi:10.3389/fphys.2018.00456
2.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1
3.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
4.) Lim J. H., J. Park, E. H. Oh, H. J. Ko, S. Hong, and Park, T. H. (2014) Nanovesicle-based bioelectronic nose for the diagnosis of lung cancer from human blood. Adv. Healthcare Mater., 3: 360–366.