☰
 

SMILES:
CCCCCCC=O

Aroma Description:
aldehydic, cognac, fatty, fresh, green, herbal, ozone1

Receptor log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
OR1A2 -6.77 5, -6.77 6, -6.77 10 4 6, 0 11  ozone, orange, aldehydic, peel, citrus, spearmint, caraway, rose, green, tart
OR1A1 -6.49 5, -6.49 6, -6.49 10 -  passionfruit, herbal, orange, caraway, weedy, hay, spearmint, licorice, plastic, mushroom
OR1J2 - 10 11  cognac, ozone, aldehydic, peel
VN1R4 - 8 7  peel, orange_peel, aldehydic, orris, fatty, cognac, ozone
OR2W1 -4.06 4 7.8 4  sweet, herbal, tart, fatty, orange, passionfruit, fresh, mimosa, rancid, mushroom
VN1R3 - 7 7  orange_peel, aldehydic
OR1D2 -2.71 9 -  rose, peach, bois_de_rose, citrus, floral, fresh, lactonic, coconut, lime, waxy
OR1G1 - 3.0457 2, 0 11  waxy, tart, orange, sweet, aldehydic, medicinal, citrus, clean, fresh, anise
OR52D1 - 1.1168 2, 0 11  anise, cheesy, rancid, orange, dairy, sour, sweet, tart, sharp, pineapple
VN1R1 - 0.3 7, 0.125 8  grapefruit, lemon, natural, lactonic, jasmine, tropical, oily
OR7D4 - 0.2 3  animal
OR10J5 - 0 4   
OR2C1 - 0 4   
OR2J2 - 0 4   
OR51E1 - 0 4   
OR51L1 - 0 4   
OR5P3 - 0 4   
OR10C1 - 0 11   
OR10G7 - 0 11   
OR10H1 - 0 11   
OR10H4 - 0 11   
OR11G2 - 0 11   
OR13C2 - 0 11   
OR1E2 - 0 11   
OR2B2 - 0 11   
OR2H2 - 0 11   
OR2T4 - 0 11   
OR3A1 - 0 11   
OR4D9 - 0 11   
OR4K14 - 0 11   
OR4P4 - 0 11   
OR4S1 - 0 11   
OR4X1 - 0 11   
OR51T1 - 0 11   
OR56B4 - 0 11   
OR5I1 - 0 11   
OR6S1 - 0 11   
OR4D11 - 0 12   

SMILES:
CCCCCCC=O

Aroma Description:
aldehydic, cognac, fatty, fresh, green, herbal, ozone

Receptor Docking Score Correlated Perceptual Qualities

1.) The Good Scents Company

2.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

3.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.

4.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

5.) Silva Teixeira CS, Silva Ferreira AC, Cerqueira NM. Studying Haloanisoles Interaction with Olfactory Receptors. ACS Chem Neurosci. 2016 Jul 20;7(7):870-85. doi: 10.1021/acschemneuro.5b00335. Epub 2016 May 9. PMID: 27092849.

6.) Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J Struct Biol. 2007 Sep;159(3):400-12. doi: 10.1016/j.jsb.2007.04.013. Epub 2007 May 25. PMID: 17601748.

7.) Krautwurst D. Human olfactory receptor families and their odorants. Chem Biodivers. 2008 Jun;5(6):842-52. doi: 10.1002/cbdv.200890099. PMID: 18618407.

8.) I. Wallrabenstein, J. Gerber, S. Rasche, I. Croy, S. Kurtenbach, T. Hummel, H. Hatt, The smelling of Hedione results in sex-differentiated human brain activity, NeuroImage, Volume 113, 2015, Pages 365-373, ISSN 1053-8119

9.) Veithen, A.; Wilin, F.; Philippeau, M.; Chatelain, P. OR1D2 is a broadly tuned human olfactory receptor. Chem. Senses 2015, 40, 262–263.

10.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

11.) Lim J. H., J. Park, E. H. Oh, H. J. Ko, S. Hong, and Park, T. H. (2014) Nanovesicle-based bioelectronic nose for the diagnosis of lung cancer from human blood. Adv. Healthcare Mater., 3: 360–366.

12.) Cho, S.W., Ko, H.J. & Park, T.H. Identification of a Lung Cancer Biomarker Using a Cancer Cell Line and Screening of Olfactory Receptors for Biomarker Detection. Biotechnol Bioproc E 26, 55–62 (2021).