Olfactory Receptor family 2 subfamily AG member 1.
Sequence:
10 20 30 40 50 60 70 80 90 100 MELWNFTLGS GFILVGILND SGSPELLCAT ITILYLLALI SNGLLLLAIT MEARLHMPMY LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ 110 120 130 140 150 160 170 180 190 200 MFLALTMGGA EDLLLAFMAY DRYVAICHPL TYMTLMSSRA CWLMVATSWI LASLSALIYT VYTMHYPFCR AQEIRHLLCE IPHLLKVACA DTSRYELMVY 210 220 230 240 250 260 270 280 290 300 VMGVTFLIPS LAAILASYTQ ILLTVLHMPS NEGRKKALVT CSSHLTVVGM FYGAATFMYV LPSSFHSTRQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA 310 320 LRRVLGKYML PAHSTL
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 S G S D F G G F S T Y R S T D P L Q R T S L E P D A L L A C V T Y I L E Y V Y M F I N D T A C L A K P T L F M Q L A S V Y V M T A A F V S I I T I V V S T L A L S A L V G M G Y F M I T Y L L Y L T F L L A G G M I W S I L F T G V V A P T V I L A D M L L D E T A V M L S P T L H S P N L L G N S S L Q G F A L L L W C L I A A S C T S Y I L L L L L L L Y A M A R S S Y S A V L A K L T I A Y M P M V Y R D L I Q T K R G C I A V T L E N S P H H L UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| phenirate | - | 10 1 | floral, fruity, honey, rose, sweet, tropical, waxy | |
| bean pyrazine | -6.7 2 | 7.8632 3 | beany, chocolate, earthy, green_pea, nutty | |
| 2-sec-butyl-3-methoxypyrazine | -6.4 3 | 7.094 3 | musty, green, pea, galbanum, bell, pepper | |
| isoamyl acetate | - | 8.617 1 | banana, fruity, solvent, sweet | |
| galbanum pyrazine | -6.1 2 | 6.7521 3 | green, pea, pepper | |
| 2-ethyl pyridine | -4 2 | 10 2 | green, grassy | |
| phenethyl acetate | - | 7.9787 1 | floral, fruity, honey, rose, sweet, tropical | |
| isoamyl benzoate | - | 7.6596 1 | balsamic, green, sweet, waxy | |
| prenyl acetate | - | 7.5532 1 | balsamic, banana, fresh, fruity, heliotrope, jasmine, ripe, sweet | |
| n-amyl butyrate | -0.65 4 | 10 5 | banana, cherry, fruity, pineapple, sweet, tropical | |
| earthy pyrazine | -4 2 | 1.8803 3 | bell_pepper, earthy, nutty, raw_potato | |
| 2-isobutyl-3-methylpyrazine | -3.8 2 | 2.1368 3 | herbal, green, sugar | |
| 2-isobutylthiazole | -4.2 3 | 1.1966 3 | green, wasabi, privet, tomato, leaf, earthy, vegetable, metallic | |
| shoyu pyrazine | -3 3 | 0.6838 3 | nutty, pepper, raw | |
| androstadienone | -1.5 4 | 0.0494 4 | animal, musky | |
| o-isopropylanisole | - | 0.0588 2 | ||
| acetic acid | - | 0 6 | acrid, sharp, vinegar | |
| 2-acetyl-3,5-dimethyl pyrazine | - | 0 3 | nutty, hazelnut, roasted_hazelnut | |
| almond pyrazine | - | 0 3 | roasted, almond, hazelnut, peanut | |
| butyl butyrate | - | 0 6 | banana, fruity, pineapple, sweet | |
| 2,5-dimethyl pyrazine | - | 0 3 | cocoa, nutty, roasted, beefy, woody, grassy, medicinal | |
| 2,6-dimethylpyrazine | - | 0 3 | ethereal, cocoa, nutty, roasted, meaty, roasted_meaty, beefy, brown, coffee, buttermilk | |
| ethanol | - | 0 6 | alcoholic, ethereal, fruity | |
| 3-ethyl pyridine | - | 0 3 | tobacco, oakmoss, leathery, caramellic, roasted, hazelnut | |
| 2-ethyl-3,5-dimethylpyrazine | - | 0 3 | almond, burnt, caramellic, cocoa, coffee, musty, nutty, peanut, roasted | |
| filbert pyrazine | - | 0 3 | nutty, peanut, musty, corn, raw, earthy, bready | |
| hazelnut pyrazine | - | 0 3 | earthy, green, hazelnut, meaty, musty, nutty, potato, roasted, toasted, vegetable | |
| helional | - | 0 6 | cyclamen, fresh, green, hay, ozone, watery | |
| hexyl butyrate | - | 0 6 | apple, estery, fruity, green, soapy, sweet, vegetable, waxy | |
| hydrochloric acid | - | 0 6 | ||
| 2,4-lutidine | - | 0 3 | smoky, phenolic | |
| 2,5-lutidine | - | 0 3 | roasted, green, earthy | |
| 2-methoxy-3,5-dimethylpyrazine | - | 0 3 | earthy | |
| methyl alcohol | - | 0 6 | alcoholic | |
| methyl isoeugenol | - | 0 3 | spicy, clove, floral, carnation, woody | |
| 6-methyl quinoline | - | 0 3 | leathery, tonka, castoreum, tobacco, civet, fecal | |
| 2-methylthio-3-methylpyrazine | - | 0 3 | roasted, meaty, nutty, almond, vegetable | |
| phenylpropyl alcohol | - | 0 6 | balsamic, cinnamon, cinnamyl, floral, fruity, honey, hyacinth, spicy, sweet | |
| piperonal | - | 0 6 | coconut, heliotrope, powdery, sweet, vanilla | |
| propyl butyrate | - | 0 6 | fruity, sweet, apricot, pineapple, rancid, sweaty | |
| safrole | - | 0 6 | anise, floral, sassafrass, spicy, sweet, warm, woody | |
| 1,2,4-trimethylbenzene | - | 0 3 | ||
| 2,3,5-trimethylpyrazine | - | 0 3 | nutty, nut_skin, earthy, powdery, cocoa, potato, baked_potato, peanut, roasted_peanut, hazelnut, musty | |
| 2,3,5-trimethylpyridine | - | 0 3 | ||
| 2-ethyl pyrazine | -3.5 2 | -0.5882 2 | peanut, butter, musty, nutty, woody, roasted, cocoa, fermented, meaty |
1.) Gelis L, Wolf S, Hatt H, Neuhaus EM, Gerwert K. Prediction of a ligand-binding niche within a human olfactory receptor by combining site-directed mutagenesis with dynamic homology modeling. Angew Chem Int Ed Engl. 2012 Jan 27;51(5):1274-8. doi: 10.1002/anie.201103980. Epub 2011 Dec 5. PMID: 22144177.
2.) Chatelain P., Wilkin F., Veithen A., Philippeau M., Noiset O., Quesnel Y. Sensorial Chemistry: Functional characterization and structure-activity relationship understanding of OR5K1 and OR2AG1 allow to design and synthetize new selective compounds. Chem. Senses. 2017;42:e28.
3.) Françoise, W., Philippeau, M., Veithen, A., Chatelain, P., & Quesnel, Y. (2016, May). Functional characterization of human olfactory receptors responding to pyrazine odorants. In CHEMICAL SENSES (Vol. 41, No. 4, pp. 433-434). GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND: OXFORD UNIV PRESS.
4.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
5.) A. Mashukova, M. Spehr, H. Hatt, E.M. Neuhaus, beta-Arrestin2-Mediated Internalization of Mammalian Odorant Receptors, J. Neurosci. 26 (2006) 9902-9912.
6.) Kwon, O. S., Song, H. S., Park, S. J., Lee, S. H., An, J. H., Park, J. W., Yang, H. H., Yoon, H., Bae, J., Park, T. H. and Jang, J. (2015), An Ultrasensitive, Selective, Multiplexed Superbioelectronic Nose That Mimics the Human Sense of Smell, Nano Lett., 15: 6559-6567.