SMILES:
CC(CC1=CC2=C(C=C1)OCO2)C=O

Aroma Description:
cyclamen, fresh, green, hay, ozone, watery1

Receptor log10 EC50 Adj. Top Antagonist? Hypothesized PQ Associated Perceptual Qualities (PQs)
OR3A1 -2.69 2, -5.01 6, -5.01 7, -5.01 10 0.3715 2, 10 5, 10 11, 8.0769 12  cyclamic-newspapery14
cork_taint
OR1A1 -6.59 7, -6.59 8, -6.59 10 4 4, 5 8  leafy14
caraway, herbal, orange, cognac, weedy, spearmint, mushroom, hay, licorice, fatty
OR1A2 -6.47 7, -6.47 8, -6.47 10 6 8    orange, aldehydic, ozone, peel, citrus, spearmint, caraway, cyclamen, rose, waxy, cognac
OR2W1 - 4.6 4  allyl-demimetallic14
herbal, fatty, sweet, tart, banana, mushroom, orange, fresh, rancid, cherry, acacia, orangeflower
OR52D1 - 2.3858 3  ethereal14
cheesy, anise, orange, sour, rancid, sweet, dairy, sharp, pineapple, waxy, fruity, sweaty, banana
OR2J3 - 1.3333 4  jagged14
warm, candy, cinnamon, currant, hay, foliage
OR2J2 - 0.6 4  smooth14
tart, carnation, warm, clove, sweet, hay, cinnamon
OR1G1 - 0.3046 3  waxy14
waxy, orange, tart, aldehydic, sweet, clean, citrus, fresh, anise, dusty, fruity, medicinal, fatty, oily
OR10G3 - 0 4     
OR10G7 - 0 4     
OR10J5 - 0 4     
OR11A1 - 0 4     
OR1C1 - 0 4     
OR2A25 - 0 4     
OR2B11 - 0 4     
OR51E1 - 0 4     
OR51L1 - 0 4     
OR56A4 - 0 4     
OR8K3 - 0 4     
OR5A1 - 0 9     
OR5AN1 - 0 9     
OR2AG1 - 0 12     
OR8D1 - -0.025 4     
OR5K1 - 0 4, -0.3571 13     
OR5P3 - -2.3833 4     

1.) The Good Scents Company

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5.) Christian H. Wetzel, Markus Oles, Christiane Wellerdieck, Michael Kuczkowiak, Günter Gisselmann, Hanns Hatt Specificity and Sensitivity of a Human Olfactory Receptor Functionally Expressed in Human Embryonic Kidney 293 Cells andXenopus Laevis Oocytes Journal of Neuroscience 1 September 1999, 19 (17) 7426-7433; DOI: 10.1523/JNEUROSCI.19-17-07426.1999

6.) Jacquier V, Pick H, Vogel H. Characterization of an extended receptive ligand repertoire of the human olfactory receptor OR17-40 comprising structurally related compounds. J Neurochem. 2006 Apr;97(2):537-44. doi: 10.1111/j.1471-4159.2006.03771.x. Epub 2006 Mar 15. PMID: 16539658.

7.) Silva Teixeira CS, Silva Ferreira AC, Cerqueira NM. Studying Haloanisoles Interaction with Olfactory Receptors. ACS Chem Neurosci. 2016 Jul 20;7(7):870-85. doi: 10.1021/acschemneuro.5b00335. Epub 2016 May 9. PMID: 27092849.

8.) Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J Struct Biol. 2007 Sep;159(3):400-12. doi: 10.1016/j.jsb.2007.04.013. Epub 2007 May 25. PMID: 17601748.

9.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]

10.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

11.) Lee, S. H., Kwon, O. S., Song, H. S., Park, S. J., Sung, J. H., Jang, J. and Park, T. H. (2012), Mimicking the human smell sensing mechanism with an artificial nose platform, Biomaterials, 33: 1722- 1729.

12.) Kwon, O. S., Song, H. S., Park, S. J., Lee, S. H., An, J. H., Park, J. W., Yang, H. H., Yoon, H., Bae, J., Park, T. H. and Jang, J. (2015), An Ultrasensitive, Selective, Multiplexed Superbioelectronic Nose That Mimics the Human Sense of Smell, Nano Lett., 15: 6559-6567.

13.) Aya Kato, Naoko Saito, Michiaki Inoue, Kayoko Nomizu (2015) Method of identifying an agent for inhibiting odor of pyrazine derivatives US9057090B2

14.) PrimaryOdors.org differential experiment.

References for aroma perceptual qualities should not be taken to indicate that the authors of outside studies necessarily assigned aroma notes to the neurons that receive input from any given receptor. Rather, the findings of outside studies often constitute the information on which we base our own perceptual quality assignments.