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Olfactory Receptor family 10 subfamily H member 2.

Estimated Expression: 69% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MLGLNHTSMS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW SERSLHTPMY LFLCVLSVSE ILYTVAIIPR MLADLLSTQR SIAFLACASQ 

       110        120        130        140        150        160        170        180        190        200 
MFFSFSFGFT HSFLLTVMGY DRYVAICHPL RYNVLMSPRG CACLVGCSWA GGSVMGMVVT SAIFQLTFCG SHEIQHFLCH VPPLLKLACG NNVPAVALGV 

       210        220        230        240        250        260        270        280        290        300 
GLVCIMALLG CFLLILLSYA FIVADILKIP SAEGRNKAFS TCASHLIVVI VHYGFASVIY LKPKGPHSQE GDTLMATTYA VLTPFLSPII FSLRNKELKV 

       310        320 
AMKRTFLSTL YSSGT

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


D G E Q       P   A P V N     I A   A I S R      L L  L H P F  
 M L T   K L Y I   L A V   S T V V   A L F    D A L    M L Q   
Y T T A   V S A   L G V G   M G M   Q S A C  M R P I  L L F L  
 L V A   F G Y H   I C V   V S G G   F F M    I A V    L L F   
L F P T   V I V   L L A M   A W S   F S F S  T Y L I  F L Y M  
 I P S   V I L H   F C G   C G V L   T F G    E S V    L L T   
  S F I   S A C   L I L L   C A C   L F S H  S L V C  L L N G  
         T S F A   Y S L   G R P S   V T L    L F L    A M I   
          K N R   V I F A           D Y G M  Y M P T  S W V T  
         G E A S   I D A             V Y R                 E   
                    I K L           H C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
cascalone -3.646 1 -  marine, watery, fruity, clean
cinnamaldehyde -6 2 0.7916 2  sweet, spicy, candy, cinnamon, warm
geranyl acetate -3 2 (agonist) 2  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
calone - (agonist) 1  fresh, watery, clean, melon, green, marine, ozone, phenolic
ethyl vanillin - 0.3944 2  sweet, creamy, vanilla, caramellic

1.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1

2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
 2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR10H2Y M S F G F S F G M G V L H V P V V C A L Y A Y K A T Y A
OR10H3F M S F G F S F G M G V L H V L V V C A L Y A Y K A T Y T
OR10H4F M S F G F S F G M G V F H V L V V C A L Y A Y K A T Y T
OR10H1Y M S F G F S F G M G V A H V P V V C A L Y A Y K G I Y T
OR10H5Y M S F G F S F G M G V F H V P V V C A L Y A Y K G I Y T
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