Olfactory Receptor family 2 subfamily AT member 4.
Sequence:
10 20 30 40 50 60 70 80 90 100 MDATACNESV DGSPVFYLLG IPSLPETFFL PVFFIFLLFY LLILMGNALI LVAVVAEPSL HKPMYFFLIN LSTLDILFTT TTVPKMLSLF LLGDRFLSFS 110 120 130 140 150 160 170 180 190 200 SCLLQMYLFQ SFTCSEAFIL VVMAYDRYVA ICHPLHYPVL MNPQTNATLA ASAWLTALLL PIPAVVRTSQ MAYNSIAYIY HCFCDHLAVV QASCSDTTPQ 210 220 230 240 250 260 270 280 290 300 TLMGFCIAMV VSFLPLLLVL LSYVHILASV LRISSLEGRA KAFSTCSSHL LVVGTYYSSI AIAYVAYRAD LPLDFHIMGN VVYAILTPIL NPLIYTLRNR 310 320 DVKAAITKIM SQDPGCDRSI
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 F T E P L F S F S L R V T T D S A V D L P L P L F L S L L C S V A P I T Q P Y A I A I H F I F F V M K P V Y M Q L P L L F G M L I S S V N G M L L F T T T Q F L L A T L A I C Y Y T G A Y V L L Y F T F L I C T F S W A S S V V M V V L P T L I M L I D L T A E S A A L T P L F L H S S N L I L A N G S L N I V L I F A N T V L L L C T S Y I L P V L I L F F A M V Q P N M S L L F A K A T V V A Y M P K Y R D Y I H V Y R G E I A V S A L L S S I C L V UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| sandalore | -4.6 1 | 10 1 | sandalwood, woody, waxy, greasy, creamy, cedar | |
| brahmanol | -4.3 1 | 5 1 | sandalwood, waxy, woody, herbal, nutty | |
| isoeugenol | -5 2 | 0.5254 2 | carnation, clove, floral, spicy, sweet, woody | |
| sandranol | -4.7 1 | 0.25 1 | woody, sandalwood, greasy, oily, waxy | |
| javanol | - | 1.25 1 | tropical, woody, fatty, sandalwood, herbal, cologne, floral | |
| ebanol | - | 0 1 | sandalwood, woody, musk | |
| isobornyl cyclohexanol | - | 0 1 | sandalwood, clean, sweet, woody | |
| phenoxyethyl isobutyrate | - | 0 1 | Y | sweet, fruity, tropical, rose, honey, floral, waxy, green, apple, powdery |
| polysantol | - | 0 1 | ||
| raspberry ketone | - | 0 1 | Y | berry, floral, jammy, raspberry, ripe, seedy, sweet, woody |
| alpha-santalol | - | 0 1 | woody, sandalwood | |
| beta-santalol | - | 0 1 | woody |
1.) D. Busse, P. Kudella, N.-M. Gruning, G. Gisselmann, S. Stander, T. Luger, F. Jacobsen, L. Steinstraser, R. Paus, P. Gkogkolou et al, A Synthetic Sandalwood Odorant Induces Wound-Healing Processes in Human Keratinocytes via the Olfactory Receptor OR2AT4, J. Invest. Dermatol. 134 (2014) 2823-2832.
2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.