Names:
2,4,6-trichloroanisole
SMILES:
COC1=C(C=C(C=C1Cl)Cl)Cl
Aroma Description:
cork_taint1
| Receptor | Expression | log10 EC50 | Adj. Top | Antagonist? | Correlated Perceptual Qualities |
|---|---|---|---|---|---|
| OR5V1 | 96 | -7.51 5 | - | cork_taint | |
| OR3A1 | 92 | - | 10 2 | cork_taint | |
| OR3A4 | 73 | - | 2 4 | cork_taint, green_pea, earthy, musty | |
| OR4E2 | 96 | - | 1.9231 3 | cortex, cork_taint, foliage, solvent | |
| OR52B4 | 92 | - | 1.9231 3 | dairy, creamy, buttery, cork_taint, milky, lactonic, peach, oily, coconut | |
| OR5I1 | 46 | - | 0 3 | ||
| OR51S1 | 38 | - | 0 4 |
SMILES:
COC1=C(C=C(C=C1Cl)Cl)Cl
Aroma Description:
cork_taint
| Receptor | Expr.% | Agonist? | Dock Score | Known agonist | Correlated Perceptual Qualities |
|---|
Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.
1.) Jacquier V, Pick H, Vogel H. Characterization of an extended receptive ligand repertoire of the human olfactory receptor OR17-40 comprising structurally related compounds. J Neurochem. 2006 Apr;97(2):537-44. doi: 10.1111/j.1471-4159.2006.03771.x. Epub 2006 Mar 15. PMID: 16539658.
2.) Silva Teixeira CS, Silva Ferreira AC, Cerqueira NM. Studying Haloanisoles Interaction with Olfactory Receptors. ACS Chem Neurosci. 2016 Jul 20;7(7):870-85. doi: 10.1021/acschemneuro.5b00335. Epub 2016 May 9. PMID: 27092849.
3.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).
4.) Son, M., D. G. Cho, J. H. Lim, J. Park, S. Hong, H. J. Ko, and Park, T. H. (2015) Real-time monitoring of geosmin and 2- methylisoborneol, representative odor compounds in water pollution using bioelectronic nose with human-like performance, Biosens. Bioelectron., 74: 199–206.
5.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025