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Olfactory Receptor family 3 subfamily A member 1.

Estimated Expression: 92% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MQPESGANGT VIAEFILLGL LEAPGLQPVV FVLFLFAYLV TVRGNLSILA AVLVEPKLHT PMYFFLGNLS VLDVGCISVT VPSMLSRLLS RKRAVPCGAC 

       110        120        130        140        150        160        170        180        190        200 
LTQLFFFHLF VGVDCFLLTA MAYDRFLAIC RPLTYSTRMS QTVQRMLVAA SWACAFTNAL THTVAMSTLN FCGPNVINHF YCDLPQLFQL SCSSTQLNEL 

       210        220        230        240        250        260        270        280        290        300 
LLFAVGFIMA GTPMALIVIS YIHVAAAVLR IRSVEGRKKA FSTCGSHLTV VAIFYGSGIF NYMRLGSTKL SDKDKAVGIF NTVINPMLNP IIYSFRNPDV 

       310        320 
QSAIWRMLTG RRSLA

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

K D S L       S   L Q T S     M A   V A R K      L L  L G P A  
 A K D   G L R M   L E N   V T H T   G C P    R S L    V P Q   
F I G V   Y N F   A F L L   L A N   T L C A  M S P V  L V F V  
 V T N   I G S G   F G V   T F A C   F L Q    T V S    F L F   
M P N I   Y F I   G A M I   A W S   L H F F  I C G V  V L Y A  
 P N L   A V V T   M P T   A A V L   G V F    D L V    R V T   
    I I   L H S   V I L A   M R Q   F C D V  S L N G  S L N G  
         G C T S   Y S I   V T Q S   T L L    L F F    A L I   
          F A K   A V H I           Y A M A  Y M P T  V L V A  
         K R G E   V A A             F R D                 E   
                    I R L           C I A L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB 2
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
2,4,6-tribromoanisole - 10 1  cork_taint
2,4,6-trichloroanisole - 10 1  cork_taint
2,4,6-trichlorophenol - 10 1  cork_taint
helional -5.01 2 10 2  cyclamen, fresh, green, hay, ozone, watery
lilial -5.19 3 (agonist) 3  floral, muguet, watery, green, powdery, cumin
foliaver -5.01 3 (agonist) 3  anise, anisic, basil, fennel, green, raspberry, sweet
cinnamaldehyde -5 4 (agonist) 4  sweet, spicy, candy, cinnamon, warm
aldehyde TPM -4.95 1 (agonist) 1  
cyclamal -4.95 1 (agonist) 1  cyclamen, floral, fresh, green, musty, rhubarb
methylhydrocinnamaldehyde -4.81 1 (agonist) 1  aldehydic, floral, green, lily, marine, muguet
3-phenylbutyraldehyde -4.81 1 (agonist) 1  foliage, green, herbal, hyacinth
methyl phenyl pentanal -4.8 1 (agonist) 1  cotton_candy, heliotrope, powdery, raspberry, sweet
piperonal - 4 2  maraschino_cherry, bitter_almond, cherry, tropical, custard, vanilla, spicy, sweet, creamy, cinnamyl
piperonyl acetone - 3.8 5  berry, candy, cotton, floral, fruity, heliotrope, jammy, powdery, raspberry, sweet
piperonyl acetic acid - 3.6 6  
safrole - 2.9 2  anise, floral, sassafrass, spicy, sweet, warm, woody
dihydrojasmone -3.38 4 0.0965 4  floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody
phenylpropyl alcohol - 2.5 2  sweet, spicy, cinnamyl, floral, hyacinth, balsamic, cinnamon, fruity, honey, winey
ethyl vanillin -2.73 4 0.2887 4  sweet, creamy, vanilla, caramellic
hexyl octanoate -1.06 4 0.0666 4  fruity, green, waxy, berry, apple, estery
ethanol - 0.3846 2  alcoholic, ethereal, fruity
acetic acid - 0 2  sharp, pungent, sour, vinegar
n-amyl butyrate - 0 2  sweet, fruity, banana, pineapple, cherry, tropical
p-anisyl formate - 0 7  fruity, floral, anisic, vanilla, seaweed
butyl butyrate - 0 2  fruity, banana, pineapple, green, cherry, tropical_fruit, ripe_fruit, juicy_fruit, sweet, fresh, ripe
cinnamyl alcohol - 0 7  balsamic, cinnamon, cinnamyl, fermented, floral, green, hyacinth, powdery, spicy, sweet
heptanal - 0 8  aldehydic, cognac, fatty, fresh, green, herbal, ozone
hexyl butyrate - 0 2  green, sweet, fruity, apple, waxy, soapy, estery, vegetable
hydrochloric acid - 0 2  sharp, pungent, sour, irritating, chlorine, meaty
isobutyraldehyde - 0 7  cereal, malty
isovaleraldehyde - 0 7  ethereal, aldehydic, chocolate, peach, fatty
methyl alcohol - 0 2  alcoholic
methyl nonyl acetaldehyde - 0 7  fresh, amber, aldehydic, mossy, citrus, tuberose, metallic, waxy, coumarinic
octanal - 0 7  aldehydic, citrus, fatty, green, orange, peel, waxy
phenethyl alcohol - 0 7  floral, rose, dried_rose, sweet, fresh, bready, honey
piperonyl acetate - 0 7  floral, hawthorn, jammy, metallic, strawberry, sweet
propyl butyrate - 0 2  fruity, sweet, apricot, pineapple, rancid, sweaty
raspberry ketone - 0 7  berry, floral, jammy, raspberry, ripe, seedy, sweet, woody
vanillin - 0 5  chocolate, creamy, sweet, vanilla
bourgeonal -4.88 7 -1 1 Y 1fresh, watery, floral, cyclamen, sweet
hydrocinnamaldehyde -4.47 7 -1 6 Y 6fresh, cortex, green, leafy, foliage, balsamic, storax, aldehydic, floral, melon
alpha-methyl cinnamaldehyde -4.81 7 -1 6 Y 6sweet, cinnamon, spicy, cassia, warm, balsamic

1.) Silva Teixeira CS, Silva Ferreira AC, Cerqueira NM. Studying Haloanisoles Interaction with Olfactory Receptors. ACS Chem Neurosci. 2016 Jul 20;7(7):870-85. doi: 10.1021/acschemneuro.5b00335. Epub 2016 May 9. PMID: 27092849.

2.) Kwon, O. S., Song, H. S., Park, S. J., Lee, S. H., An, J. H., Park, J. W., Yang, H. H., Yoon, H., Bae, J., Park, T. H. and Jang, J. (2015), An Ultrasensitive, Selective, Multiplexed Superbioelectronic Nose That Mimics the Human Sense of Smell, Nano Lett., 15: 6559-6567.

3.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

4.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

5.) Christian H. Wetzel, Markus Oles, Christiane Wellerdieck, Michael Kuczkowiak, Günter Gisselmann, Hanns Hatt Specificity and Sensitivity of a Human Olfactory Receptor Functionally Expressed in Human Embryonic Kidney 293 Cells andXenopus Laevis Oocytes Journal of Neuroscience 1 September 1999, 19 (17) 7426-7433; DOI: 10.1523/JNEUROSCI.19-17-07426.1999

6.) Lee, S. H., Kwon, O. S., Song, H. S., Park, S. J., Sung, J. H., Jang, J. and Park, T. H. (2012), Mimicking the human smell sensing mechanism with an artificial nose platform, Biomaterials, 33: 1722- 1729.

7.) Jacquier V, Pick H, Vogel H. Characterization of an extended receptive ligand repertoire of the human olfactory receptor OR17-40 comprising structurally related compounds. J Neurochem. 2006 Apr;97(2):537-44. doi: 10.1111/j.1471-4159.2006.03771.x. Epub 2006 Mar 15. PMID: 16539658.

8.) Lim J. H., J. Park, E. H. Oh, H. J. Ko, S. Hong, and Park, T. H. (2014) Nanovesicle-based bioelectronic nose for the diagnosis of lung cancer from human blood. Adv. Healthcare Mater., 3: 360–366.

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