☰

Olfactory Receptor family 5 subfamily B member 17.

Estimated Expression: 61% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MENNTEVSEF ILLGLTNAPE LQVPLFIMFT LIYLITLTGN LGMIILILLD SHLHTPMYFF LSNLSLAGIG YSSAVTPKVL TGLLIEDKAI SYSACAAQMF 

       110        120        130        140        150        160        170        180        190        200 
FCAVFATVEN YLLSSMAYDR YAAVCNPLHY TTTMTTRVCA CLAIGCYVIG FLNASIQIGD TFRLSFCMSN VIHHFFCDKP AVITLTCSEK HISELILVLI 

       210        220        230        240        250        260        270        280        290        300 
SSFNVFFALL VTLISYLFIL ITILKRHTGK GYQKPLSTCG SHLIAIFLFY ITVIIMYIRP SSSHSMDTDK IASVFYTMII PMLSPIVYTL RNKDVKNAFM 

       310        320 
KVVEKAKYSL DSVF

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


D T D M     S P   I H K E     T D   S I A K      L L  L E P A  
 A I K   R I Y M   L E S   G I Q I   A S Y    G T L    P V Q   
Y F V S   I I V   L V L I   S A N   Q A A C  V K P T  M I F L  
 I M T   T I Y F   S S I   L F G I   F F M    V A S    L T F   
L M P I   L F I   F V N F   V Y C   F V A C  S Y G I  I L Y I  
 I P S   A I L H   L A F   G I A L   V T A    G A L    T L T   
    Y V   S G C   L T V L   C A C   L Y N E  S L N S  G L N G  
         T S L P   Y S I   V R T T   S S L    L F F    I I M   
          K Q Y   L I F L           D Y A M  Y M P T  L L I L  
         G K G T   I T I             A Y R                 D   
                    R K L           N C V A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
floralozone -3.9 1 9 1  clean, fresh, green, marine, ozone
eugenyl acetate -4 1 (agonist) 1  carnation, clove, floral, fresh, malty, spicy, sweet, woody
jasmonyl -3 1 (agonist) 1  floral, herbal, oily, green, jasmine, mushroom, lactonic

1.) D. Gonzalez-Kristeller, J.B.P. do Nascimento, P.A.F. Galante, B. Malnic, Identification of agonists for a group of human odorant receptors, Front. Pharmacol. 6 (2015)
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR5B17100 61%Y M C A A T N Y G N A Q F D K P L I S N V Y V Y S S V Y T
OR5B285 100%Y M F V A T N Y G N A H F D V P L M S N I Y V Y S S V Y A
OR5B2182 100%Y F F V A T C Y G N A H F D I P V V A N V Y I Y N S V Y T
OR10A382 100%F M I L G G C F G V A Q F E T P A G T I V Y A Y K S L Y T
OR5B382 88%Y M F V A T N Y G N A H F D I P L V V N I Y I Y S P V Y T
OR5F180 26%N M F I A T C I G N F N F D S P S L A N I Y C Y S S V Y T
OR8H280 88%Y M F A G T C Y G D S N F D T S I I V T L Y L Y R S V Y T
OR2T880 96%L I L P G G C F G D G Q F E T P M C C M L Y A Y K S A Y T
OR2T3380 92%L I L P G G C F G D G Q F E T P M C C M L Y A Y K S A Y T
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