SMILES:
C1CCCCCC(=O)OCCOC(=O)CCCCC1
Aroma Description:
ambrette, floral, musk, powdery, sweet, woody1
| Receptor | log10 EC50 | Adj. Top | Antagonist? | Hypothesized PQ | Associated Perceptual Qualities (PQs) |
|---|---|---|---|---|---|
| OR5AN1 | -0.95 6 | 0.16 4, 1.5 5, 6.4286 6 | musky7 |
musk, powdery, animal | |
| OR5L1 | -2.66 2 | 0.2304 2 | currant, plum, ambrette, berry, honey, buttery, tobacco | ||
| OR4N4 | -2.41 2 | 0.3598 2 | (insufficient data) | ||
| OR5A2 | - | 2.5 5 | musky5 |
musk, animal | |
| OR51Q1 | -1.75 2 | 0.2004 2 | milky, lactonic, dairy, peach, coconut, ambrette, creamy | ||
| OR2J3 | - | 0.4 4 | jagged8 |
warm, candy, cinnamon, currant, hay, foliage | |
| OR7D4 | - | 0.2 3 | animalic3 |
animal | |
| OR1A1 | - | 0 4 | |||
| OR5A1 | - | 0 5 |
1.) The Good Scents Company
2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
3.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.
4.) Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection Narumi Sato-Akuhara, Nao Horio, Aya Kato-Namba, Keiichi Yoshikawa, Yoshihito Niimura, Sayoko Ihara, Mika Shirasu, Kazushige Touhara Journal of Neuroscience 20 April 2016, 36 (16) 4482-4491; DOI: 10.1523/JNEUROSCI.3259-15.2016
5.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]
6.) Omura M, Takabatake Y, Lempert E, Benjamin-Hong S, D'Hulst C, Feinstein P. A genetic platform for functionally profiling odorant receptors in olfactory cilia ex vivo. Sci Signal. 2022 Aug 9;15(746):eabm6112. doi: 10.1126/scisignal.abm6112. Epub 2022 Aug 9. PMID: 35944068.
7.) M. Shirasu, K. Yoshikawa, Y. Takai, A. Nakashima, H. Takeuchi, H. Sakano, K. Touhara, Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors, Neuron 81 (2014) 165-178.
8.) PrimaryOdors.org differential experiment.
References for aroma perceptual qualities should not be taken to indicate that the authors of outside studies necessarily assigned aroma notes to the neurons that receive input from any given receptor. Rather, the findings of outside studies often constitute the information on which we base our own perceptual quality assignments.