Olfactory Receptor family 5 subfamily AN member 1.
Sequence:
10 20 30 40 50 60 70 80 90 100 MTGGGNITEI TYFILLGFSD FPRIIKVLFT IFLVIYITSL AWNLSLIVLI RMDSHLHTPM YFFLSNLSFI DVCYISSTVP KMLSNLLQEQ QTITFVGCII 110 120 130 140 150 160 170 180 190 200 QYFIFSTMGL SESCLMTAMA YDRYAAICNP LLYSSIMSPT LCVWMVLGAY MTGLTASLFQ IGALLQLHFC GSNVIRHFFC DMPQLLILSC TDTFFVQVMT 210 220 230 240 250 260 270 280 290 300 AILTMFFGIA SALVIMISYG YIGISIMKIT SAKGRSKAFN TCASHLTAVS LFYTSGIFVY LSSSSGGSSS FDRFASVFYT VVIPMLNPLI YSLRNKEIKD 310 320 ALKRLQKRKC C
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 I R P F L G V F T L A F F T D S F S S S V K I N S L I I C G I Q F V Q V L Y V F F R D I T F L M K P V I F Y Q L S A I A T M I G S F V S A V L F T S S T S F T L G T M T L T Y F L V T Y T I Y I I Y C V S L G M M Y A I G F F S V A M P I V A L S D I F C S E G L V M A S A T L H S P N L S L N W S L N S A T M L W V C M I V L A C T S Y I L V I L L F F Y A M L T P S Y S I N F A K L R I L Y M P T A Y R D G I Y G S R G C I A I S I K A S T N K M UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| musk tibetene | -7.48 1 | 9.4776 2 | fatty, musk, powdery, sweet | |
| musk ketone | -6.8 1 | 10 2 | dry, fatty, floral, musk, powdery, soapy | |
| muscone | -6.54 1 | 10 3 | animal, fatty, musk, natural, powdery, sweet | |
| cyclopentadecanone | -6.43 1 | 8.9552 2 | animal, greasy, musk, natural, powdery | |
| civetone | -6.06 1 | 9.2857 1 | animal, clean, dry, musk, sweet | |
| velvione | - | 9.0299 2 | amber, civet, dry, musk, powdery | |
| cyclopentadecanol | - | 8.9552 2 | musk | |
| cosmone | - | 8.5 4 | ambergris, animal, anisic, cloth, fatty, laundered, musk, powdery, woody | |
| muscenone | -6.58 1 | 6 4 | animal, musk, soapy | |
| musk xylene | - | 7.7612 2 | dry, fatty, musk, soapy, sweet | |
| habanolide | -5.66 1 | 5.7143 1 | animal, cloth, dry, laundered, metallic, musk, powdery, sweet, tropical, waxy | |
| globanone | - | 7 4 | animal, balsamic, cloth, dry, floral, laundered, musk, tobacco, waxy | |
| ambrettolide | -5.64 1 | 3.5714 1 | amber, berry, fruity, musk, soapy, sweet | |
| isomuscone | -2.45 2 | 8.2836 2 | animal, musk, powdery | |
| galaxolide | -6.45 1 | 1.4286 1 | floral, musk, sweet | |
| dihydrocivetone | -2.66 2 | 3.7313 2 | musk | |
| ethylene brassylate | -0.95 1 | 6.4286 1 | ambrette, floral, musk, powdery, sweet, woody | |
| thiacyclopentadecane-1-oxide | -2.53 2 | 3.0597 2 | musk | |
| beta-ionone | -2.8 5 | 1.0526 5 | beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent | |
| pentadecalactone | - | 2.3881 2 | animal, fruity, musk, natural, powdery | |
| 3-methylcyclotetradecanone | - | 0.8 6 | ||
| oxacyclohexan-2-one | - | 0.16 6 | ||
| cashmeran | - | 0.0004 6 | clean, musk, spicy, woody | |
| cyclodecanone | - | 0.0004 6 | ||
| cyclohexanone | - | 0.0004 6 | acetone, minty | |
| cyclopentadecane | - | 0.0004 6 | ||
| cycloundecanone | - | 0.0004 6 | ||
| 2-pentadecanone | - | 0.0004 6 | burnt, celery, fatty, fresh, jasmine, oily, waxy | |
| 8-pentadecanone | - | 0.0004 6 | ||
| tonalide | - | 0.0004 6 | amber, ambrette, fruity, musk, powdery, sweet | |
| acetic acid | - | 0 4 | acrid, sharp, vinegar | |
| acetophenone | - | 0 4 | sweet, pungent, hawthorn, mimosa, almond, acacia, chemical | |
| aldehyde C-10 | - | 0 4 | aldehydic, citrus, floral, orange, peel, sweet, waxy | |
| aldehyde C-8 | - | 0 4 | aldehydic, citrus, fatty, green, orange, peel, waxy | |
| aldehyde MNA | - | 0 4 | fresh, amber, aldehydic, mossy, citrus, tuberose, metallic, waxy, coumarinic | |
| amber butanol | - | 0 4 | woody, amber, ambrette | |
| amber xtreme | - | 0 4 | animal, musk, woody, spicy | |
| amberketal | - | 0 4 | dry, amber, powdery, woody, musk | |
| ambrinol | - | 0 4 | amber, natural, musk, animal | |
| ambroxide | - | 0 4 | amber, ambergris, cedar, dry, green, musk, paper, pine, seedy, woody | |
| benzoic acid | - | 0 4 | balsamic, urine | |
| benzyl propionate | - | 0 4 | apple, balsamic, banana, floral, fruity, jammy, jasmine, sweet | |
| boisambrene | - | 0 4 | woody, cedar, ambergris, dry, dusty, amber | |
| borneol | - | 0 4 | camphoraceous, peppery, pine, woody | |
| p-t-butyl cyclohexanone | - | 0 4 | woody, minty, patchouli, musk, leathery | |
| calone | - | 0 4 | fresh, watery, clean, melon, green, marine, ozone, phenolic | |
| camphene | - | 0 4 | woody, herbal, fir_needle | |
| camphor | - | 0 4 | camphoraceous | |
| caproic acid | - | 0 4 | cheesy, fatty, sour, sweaty | |
| caprylic acid | - | 0 4 | cheesy, fatty, oily, rancid, vegetable, waxy | |
| (R)-(-)-carvone | - | 0 4 | herbal, minty, spearmint, sweet | |
| celestolide | - | 0 6 | ambergris, animal, cedar, musk, woody | |
| 1,4-cineol | - | 0 4 | cooling, pine, minty, camphoraceous, terpenic, green | |
| claritone | - | 0 4 | sweet, herbal, clary_sage, sage, bergamot, petitgrain, tropical, citrus | |
| p-cresyl phenyl acetate | - | 0 4 | animal, rose, honey, narcissus, lily, hyacinth | |
| cyclododecanone | - | 0 4 | ||
| beta-damascone | - | 0 4 | berry, currant, floral, fruity, honey, plum, rose, tobacco | |
| gamma-decalactone | - | 0 4 | buttery, coconut, fresh, oily, peach, sweet, waxy | |
| 1-decanol | - | 0 4 | aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy | |
| delta-dodecalactone | - | 0 4 | buttery, coconut, fresh, metallic, oily, peach, sweet | |
| 1-dodecanol | - | 0 4 | aldehydic, coconut, earthy, fatty, honey, soapy, waxy | |
| omega-dodecanolactam | - | 0 4 | ||
| exaltolide | - | 0 4 | musk, animal, powdery, natural, fruity | |
| fructone | - | 0 4 | apple, fruity, green, plum, sweet, tropical, woody | |
| geraniol | - | 0 4 | citrus, floral, fruity, rose, sweet, waxy | |
| helional | - | 0 4 | cyclamen, fresh, green, hay, ozone, watery | |
| helvetolide | - | 0 6 | ambrette, floral, fruity, musk, pear, woody | |
| hexanal | - | 0 4 | aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty | |
| 1-hexanol | - | 0 4 | alcoholic, ethereal, fruity, fusel, green, herbal, oily, pungent, sweet | |
| cis-3-hexen-1-ol | - | 0 4 | foliage, fresh, grassy, green, herbal, oily, vegetable | |
| cis-3-hexenyl hexanoate | - | 0 4 | fruity, green, waxy, pear, winey, tropical, grassy, pineapple | |
| Iso-E-Super | - | 0 4 | ambergris, cedar, dry, ketonic, old_wood, phenolic, woody | |
| isoamyl butyrate | - | 0 4 | fruity, green, apricot, pear, banana | |
| isoborneol | - | 0 4 | balsamic, camphoraceous, herbal, woody | |
| isobornyl acetate | - | 0 4 | balsamic, camphoraceous, citrus, herbal, soapy, sweet, woody | |
| isolongifolanone | - | 0 4 | dry, woody, patchouli, cedar, earthy, tobacco, incense | |
| isomenthone | - | 0 4 | minty, cooling, peppermint, sweet | |
| isovaleric acid | - | 0 4 | cheesy, sour, sweaty, tropical | |
| jasmolactone delta | - | 0 4 | oily, fruity, coconut, floral, petal, jasmine, tuberose, peach, apricot | |
| d-limonene | - | 0 4 | citrus, fresh, orange, sweet | |
| melonal | - | 0 4 | fresh, ozone, melon, watermelon, sweet, clean, green | |
| (-)-menthol | - | 0 4 | cooling, mentholic, minty, peppermint | |
| methyl cinnamate | - | 0 4 | balsamic, cherry, strawberry, sweet | |
| 6-methyl quinoline | - | 0 4 | leathery, tonka, castoreum, tobacco, civet, fecal | |
| gamma-nonalactone | - | 0 4 | buttery, coconut, creamy, oily, sweet, waxy | |
| gamma-octalactone | - | 0 4 | coconut, creamy, dairy, fatty, sweet, tonka, waxy | |
| 1-octanol | - | 0 4 | aldehydic, green, mushroom, orange, rose, waxy | |
| oranger crystals | - | 0 4 | honey, neroli, orangeflower, powdery, sweet | |
| orris hexanone | - | 0 4 | woody, dry, orris, earthy, camphoraceous | |
| phenethyl acetate | - | 0 4 | floral, fruity, honey, rose, sweet, tropical | |
| phenylacetic acid | - | 0 4 | sweet, honey, floral, honeysuckle, sour, waxy, civet | |
| piperonyl acetone | - | 0 4 | berry, candy, cotton, floral, fruity, heliotrope, jammy, powdery, raspberry, sweet | |
| raspberry ketone | - | 0 4 | berry, floral, jammy, raspberry, ripe, seedy, sweet, woody | |
| romandolide | - | 0 4 | musk, ambrette, fruity, berry | |
| santaliff | - | 0 4 | sandalwood, creamy, woody, milky, waxy, greasy, musk | |
| (R)-(+)-sclareolide | - | 0 4 | dry, paper, woody, ambergris, labdanum | |
| styralyl acetate | - | 0 4 | green, leafy, gardenia, rhubarb, musty | |
| sulcatone | - | 0 4 | apple, banana, cheesy, citrus, creamy, fruity, green, ketonic, lemongrass, musty | |
| alpha-terpinene | - | 0 4 | woody, terpenic, lemon, herbal, medicinal, citrus | |
| tonka undecanone | - | 0 4 | sweet, spicy, balsamic, tonka, woody, tobacco, green | |
| gamma-undecalactone | - | 0 4 | apricot, coconut, creamy, fatty, fruity, ketonic, lactonic, peach | |
| valeric acid | - | 0 4 | acidic, cheesy, fruity, milky, sharp, sour, tobacco | |
| gamma-valerolactone | - | 0 4 | cocoa, herbal, sweet, tobacco, warm, woody | |
| woody cyclohexanone | - | 0 4 | woody, old_wood, amber, tobacco, herbal | |
| ysamber | - | 0 4 | dry, woody, vetiver, amber, powdery, musk, fruity |
1.) Omura M, Takabatake Y, Lempert E, Benjamin-Hong S, D'Hulst C, Feinstein P. A genetic platform for functionally profiling odorant receptors in olfactory cilia ex vivo. Sci Signal. 2022 Aug 9;15(746):eabm6112. doi: 10.1126/scisignal.abm6112. Epub 2022 Aug 9. PMID: 35944068.
2.) Ahmed, Lucky et al "Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds." Proceedings of the National Academy of Sciences 115.17 (2018): E3950-E3958. Web. 29 Aug. 2021.
3.) M. Shirasu, K. Yoshikawa, Y. Takai, A. Nakashima, H. Takeuchi, H. Sakano, K. Touhara, Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors, Neuron 81 (2014) 165-178.
4.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]
5.) S.R. Jaeger, J.F. McRae, C.M. Bava, M.K. Beresford, D. Hunter, Y. Jia, S.L. Chheang, D. Jin, M. Peng, J.C. Gamble et al, A Mendelian Trait for Olfactory Sensitivity Affects Odor Experience and Food Selection, Curr. Biol. 23 (2013) 1601-1605.
6.) Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection Narumi Sato-Akuhara, Nao Horio, Aya Kato-Namba, Keiichi Yoshikawa, Yoshihito Niimura, Sayoko Ihara, Mika Shirasu, Kazushige Touhara Journal of Neuroscience 20 April 2016, 36 (16) 4482-4491; DOI: 10.1523/JNEUROSCI.3259-15.2016