Olfactory Receptor family 5 subfamily A member 1.
Sequence:
10 20 30 40 50 60 70 80 90 100 MSITKAWNSS SVTMFILLGF TDHPELQALL FVTFLGIYLT TLAWNLALIF LIRGDTHLHT PMYFFLSNLS FIDICYSSAV APNMLTDFFW EQKTISFVGC 110 120 130 140 150 160 170 180 190 200 AAQFFFFVGM GLSECLLLTA MAYDRYAAIS SPLLYPTIMT QGLCTRMVVG AYVGGFLSSL IQASSIFRLH FCGPNIINHF FCDLPPVLAL SCSDTFLSQV 210 220 230 240 250 260 270 280 290 300 VNFLVVVTVG GTSFLQLLIS YGYIVSAVLK IPSAEGRWKA CNTCASHLMV VTLLFGTALF VYLRPSSSYL LGRDKVVSVF YSLVIPMLNP LIYSLRNKEI 310 320 KDALWKVLER KKVFS
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 L E P H F G V F S S L F T D P R R G L L L A Q D T L A A C S A Q I V Q S L Y V F V K D T V F L M N P A F F F Q L S S L F N V L A T F V S V G L F V A S G V F L F G G V V V G F L L L S Y T L Y I S Y C I S L G M V Y A G G V T T V V M P I V A L T D I F L C E G V V M F S T M L H S P N L A L N W S L N S A T L L R T C L L Q L A C T S Y I L F I L L F F Y A M L G Q T Y S I N C A K L R I L Y M P T A Y R D V I Y G W R G S I A V A S E A S P S K L UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| ambrinol | - | 10 1 | amber, natural, musk, animal | |
| beta-ionone | -5.35 2 | 10 3 | beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent | |
| ysamber | - | 0.5 1 | dry, woody, vetiver, amber, powdery, musk, fruity | |
| acetic acid | - | 0 1 | acrid, sharp, vinegar | |
| acetophenone | - | 0 1 | sweet, pungent, hawthorn, mimosa, almond, acacia, chemical | |
| aldehyde C-10 | - | 0 1 | aldehydic, citrus, floral, orange, peel, sweet, waxy | |
| aldehyde C-8 | - | 0 1 | aldehydic, citrus, fatty, green, orange, peel, waxy | |
| aldehyde MNA | - | 0 1 | fresh, amber, aldehydic, mossy, citrus, tuberose, metallic, waxy, coumarinic | |
| amber butanol | - | 0 1 | woody, amber, ambrette | |
| amber xtreme | - | 0 1 | animal, musk, woody, spicy | |
| amberketal | - | 0 1 | dry, amber, powdery, woody, musk | |
| ambrettolide | - | 0 1 | amber, berry, fruity, musk, soapy, sweet | |
| ambroxide | - | 0 1 | amber, ambergris, cedar, dry, green, musk, paper, pine, seedy, woody | |
| benzoic acid | - | 0 1 | balsamic, urine | |
| benzyl propionate | - | 0 1 | apple, balsamic, banana, floral, fruity, jammy, jasmine, sweet | |
| boisambrene | - | 0 1 | woody, cedar, ambergris, dry, dusty, amber | |
| borneol | - | 0 1 | camphoraceous, peppery, pine, woody | |
| p-t-butyl cyclohexanone | - | 0 1 | woody, minty, patchouli, musk, leathery | |
| calone | - | 0 1 | fresh, watery, clean, melon, green, marine, ozone, phenolic | |
| camphene | - | 0 1 | woody, herbal, fir_needle | |
| camphor | - | 0 1 | camphoraceous | |
| caproic acid | - | 0 1 | cheesy, fatty, sour, sweaty | |
| caprylic acid | - | 0 1 | cheesy, fatty, oily, rancid, vegetable, waxy | |
| (R)-(-)-carvone | - | 0 1 | herbal, minty, spearmint, sweet | |
| celestolide | - | 0 1 | ambergris, animal, cedar, musk, woody | |
| 1,4-cineol | - | 0 1 | cooling, pine, minty, camphoraceous, terpenic, green | |
| civetone | - | 0 1 | animal, clean, dry, musk, sweet | |
| claritone | - | 0 1 | sweet, herbal, clary_sage, sage, bergamot, petitgrain, tropical, citrus | |
| cosmone | - | 0 1 | ambergris, animal, anisic, cloth, fatty, laundered, musk, powdery, woody | |
| p-cresyl phenyl acetate | - | 0 1 | animal, rose, honey, narcissus, lily, hyacinth | |
| cyclododecanone | - | 0 1 | ||
| cyclopentadecane | - | 0 1 | ||
| cyclopentadecanol | - | 0 1 | musk | |
| cyclopentadecanone | - | 0 1 | animal, greasy, musk, natural, powdery | |
| beta-damascone | - | 0 1 | berry, currant, floral, fruity, honey, plum, rose, tobacco | |
| gamma-decalactone | - | 0 1 | buttery, coconut, fresh, oily, peach, sweet, waxy | |
| 1-decanol | - | 0 1 | aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy | |
| delta-dodecalactone | - | 0 1 | buttery, coconut, fresh, metallic, oily, peach, sweet | |
| 1-dodecanol | - | 0 1 | aldehydic, coconut, earthy, fatty, honey, soapy, waxy | |
| omega-dodecanolactam | - | 0 1 | ||
| ethylene brassylate | - | 0 1 | ambrette, floral, musk, powdery, sweet, woody | |
| exaltolide | - | 0 1 | musk, animal, powdery, natural, fruity | |
| fructone | - | 0 1 | apple, fruity, green, plum, sweet, tropical, woody | |
| galaxolide | - | 0 1 | floral, musk, sweet | |
| geraniol | - | 0 1 | citrus, floral, fruity, rose, sweet, waxy | |
| globanone | - | 0 1 | animal, balsamic, cloth, dry, floral, laundered, musk, tobacco, waxy | |
| habanolide | - | 0 1 | animal, cloth, dry, laundered, metallic, musk, powdery, sweet, tropical, waxy | |
| helional | - | 0 1 | cyclamen, fresh, green, hay, ozone, watery | |
| helvetolide | - | 0 1 | ambrette, floral, fruity, musk, pear, woody | |
| hexanal | - | 0 1 | aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty | |
| 1-hexanol | - | 0 1 | alcoholic, ethereal, fruity, fusel, green, herbal, oily, pungent, sweet | |
| cis-3-hexen-1-ol | - | 0 1 | foliage, fresh, grassy, green, herbal, oily, vegetable | |
| cis-3-hexenyl hexanoate | - | 0 1 | fruity, green, waxy, pear, winey, tropical, grassy, pineapple | |
| Iso-E-Super | - | 0 1 | ambergris, cedar, dry, ketonic, old_wood, phenolic, woody | |
| isoamyl butyrate | - | 0 1 | fruity, green, apricot, pear, banana | |
| isoborneol | - | 0 1 | balsamic, camphoraceous, herbal, woody | |
| isobornyl acetate | - | 0 1 | balsamic, camphoraceous, citrus, herbal, soapy, sweet, woody | |
| isolongifolanone | - | 0 1 | dry, woody, patchouli, cedar, earthy, tobacco, incense | |
| isomenthone | - | 0 1 | minty, cooling, peppermint, sweet | |
| isovaleric acid | - | 0 1 | cheesy, sour, sweaty, tropical | |
| jasmolactone delta | - | 0 1 | oily, fruity, coconut, floral, petal, jasmine, tuberose, peach, apricot | |
| d-limonene | - | 0 1 | citrus, fresh, orange, sweet | |
| melonal | - | 0 1 | fresh, ozone, melon, watermelon, sweet, clean, green | |
| (-)-menthol | - | 0 1 | cooling, mentholic, minty, peppermint | |
| methyl cinnamate | - | 0 1 | balsamic, cherry, strawberry, sweet | |
| 6-methyl quinoline | - | 0 1 | leathery, tonka, castoreum, tobacco, civet, fecal | |
| muscenone | - | 0 1 | animal, musk, soapy | |
| muscone | - | 0 1 | animal, fatty, musk, natural, powdery, sweet | |
| musk ketone | - | 0 1 | dry, fatty, floral, musk, powdery, soapy | |
| musk xylene | - | 0 1 | dry, fatty, musk, soapy, sweet | |
| gamma-nonalactone | - | 0 1 | buttery, coconut, creamy, oily, sweet, waxy | |
| gamma-octalactone | - | 0 1 | coconut, creamy, dairy, fatty, sweet, tonka, waxy | |
| 1-octanol | - | 0 1 | aldehydic, green, mushroom, orange, rose, waxy | |
| oranger crystals | - | 0 1 | honey, neroli, orangeflower, powdery, sweet | |
| orris hexanone | - | 0 1 | woody, dry, orris, earthy, camphoraceous | |
| 2-pentadecanone | - | 0 1 | burnt, celery, fatty, fresh, jasmine, oily, waxy | |
| 8-pentadecanone | - | 0 1 | ||
| phenethyl acetate | - | 0 1 | floral, fruity, honey, rose, sweet, tropical | |
| phenylacetic acid | - | 0 1 | sweet, honey, floral, honeysuckle, sour, waxy, civet | |
| piperonyl acetone | - | 0 1 | berry, candy, cotton, floral, fruity, heliotrope, jammy, powdery, raspberry, sweet | |
| raspberry ketone | - | 0 1 | berry, floral, jammy, raspberry, ripe, seedy, sweet, woody | |
| romandolide | - | 0 1 | musk, ambrette, fruity, berry | |
| santaliff | - | 0 1 | sandalwood, creamy, woody, milky, waxy, greasy, musk | |
| (R)-(+)-sclareolide | - | 0 1 | dry, paper, woody, ambergris, labdanum | |
| styralyl acetate | - | 0 1 | green, leafy, gardenia, rhubarb, musty | |
| sulcatone | - | 0 1 | apple, banana, cheesy, citrus, creamy, fruity, green, ketonic, lemongrass, musty | |
| alpha-terpinene | - | 0 1 | woody, terpenic, lemon, herbal, medicinal, citrus | |
| tonalide | - | 0 1 | amber, ambrette, fruity, musk, powdery, sweet | |
| tonka undecanone | - | 0 1 | sweet, spicy, balsamic, tonka, woody, tobacco, green | |
| gamma-undecalactone | - | 0 1 | apricot, coconut, creamy, fatty, fruity, ketonic, lactonic, peach | |
| valeric acid | - | 0 1 | acidic, cheesy, fruity, milky, sharp, sour, tobacco | |
| gamma-valerolactone | - | 0 1 | cocoa, herbal, sweet, tobacco, warm, woody | |
| woody cyclohexanone | - | 0 1 | woody, old_wood, amber, tobacco, herbal |
1.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]
2.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.
3.) S.R. Jaeger, J.F. McRae, C.M. Bava, M.K. Beresford, D. Hunter, Y. Jia, S.L. Chheang, D. Jin, M. Peng, J.C. Gamble et al, A Mendelian Trait for Olfactory Sensitivity Affects Odor Experience and Food Selection, Curr. Biol. 23 (2013) 1601-1605.