Olfactory Receptor family 2 subfamily J member 3.
Sequence:
10 20 30 40 50 60 70 80 90 100 MNDDGKVNAS SEGYFILVGF SNWPHLEVVI FVVVLIFYLM TLIGNLFIII LSYLDSHLHT PMYFFLSNLS FLDLCYTTSS IPQLLVNLWG PEKTISYAGC 110 120 130 140 150 160 170 180 190 200 MIQLYFVLAL GTTECVLLVV MSYDRYAAVC RPLHYTVLMH PRFCHLLAVA SWVSGFTNSA LHSSFTFWVP LCGHRQVDHF FCEVPALLRL SCVDTHVNEL 210 220 230 240 250 260 270 280 290 300 TLMITSSIFV LIPLILILTS YGAIVRAVLR MQSTTGLQKV FGTCGAHLMA VSLFFIPAMC IYLQPPSGNS QDQGKFIALF YTVVTPSLNP LIYTLRNKVV 310 320 RGAVKRLMGW E
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 L H P W N V L G A Y S F V H T D Q Q D Q S V V E L Q P I I M C S S H L L E N L Y I C F K G V V F I S S T F Y L Q A S N I M L T M A P F L A I I L V T Y C L A L V T F G S S S T I F F L V T Y M L Y F D L F T T G L V W S L V F I S V A S P T V I L T S L N S V C E A V A L L P I M L H A P N L F L N G L F F V V L L L H C L I L I G C T T Y I L I I I Y M P T Y S M F R P H Y S T G F V K L Y S L A Y R D V I A G Q L G C V A V A R T T S Q R R L UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| cis-3-hexen-1-ol | -5.61 1 | 10 2 | foliage, fresh, grassy, green, herbal, oily, vegetable | |
| geranyl acetate | -4.71 1 | - | floral, green, lavender, rose, waxy | |
| cinnamaldehyde | -6 3 | 2 4 | sweet, spicy, candy, cinnamon, warm | |
| musk xylene | - | 5.4 5 | dry, fatty, musk, soapy, sweet | |
| citral | - | 4.8667 6 | citrus, lemon, sharp, sweet | |
| (S)-3-mercapto-3-methylhexan-1-ol | -4.82 7 | 1.5 7 | passionfruit, currant, blackcurrant, green, fruity | |
| n-amyl acetate | -5.44 3 | 0.3362 3 | banana, fruity, solvent, sweet, apple, ethereal, pear | |
| (R)-3-mercapto-3-methylhexan-1-ol | -5.22 7 | 0.4 7 | passionfruit, currant, blackcurrant, green, fruity | |
| oranger crystals | -4.7 8 | 0.1889 8 | honey, neroli, orangeflower, powdery, sweet | |
| anisaldehyde | -3.3 9 | 0.8824 9 | anisic, balsamic, floral, hawthorn, mimosa, powdery, sweet | |
| 3-octen-2-one | - | 3 10 | earthy, spicy, herbal, sweet, mushroom, hay, blueberry | |
| 1-octanol | - | 2.5667 6 | aldehydic, green, mushroom, orange, rose, waxy | |
| methyl eugenol | - | 1.9 6 | carnation, cinnamon, clove, fresh, spicy, sweet, warm | |
| coumarin | - | 1.8333 6 | coumarinic, hay, sweet, tonka | |
| 2,4-DNT | - | 1.6333 6 | ||
| helional | - | 1.3333 6 | cyclamen, fresh, green, hay, ozone, watery | |
| velvione | - | 1.2 5 | amber, civet, dry, musk, powdery | |
| cyclopentadecanol | - | 1 5 | musk | |
| celestolide | - | 0.4 5 | ambergris, animal, cedar, musk, woody | |
| ethylene brassylate | - | 0.4 5 | ambrette, floral, musk, powdery, sweet, woody | |
| pentadecalactone | - | 0.4 5 | animal, fruity, musk, natural, powdery | |
| aldehyde C-10 | - | 0 6 | aldehydic, citrus, floral, orange, peel, sweet, waxy | |
| aldehyde C-9 | - | 0 6 | aldehydic, fatty, fresh, orange, orris, peel, peely, rose, waxy | |
| allyl phenylacetate | - | 0 6 | fruity, honey, rummy | |
| ambrettolide | - | 0 5 | amber, berry, fruity, musk, soapy, sweet | |
| amyl hexanoate | - | 0 6 | apple, estery, fatty, fruity, green, pear, pineapple, sweet | |
| androstenone | - | 0 6 | animal, musky | |
| l-arabinose | - | 0 6 | ||
| benzene | - | 0 6 | ||
| butyl formate | - | 0 6 | brandy, fruity, plum, rummy | |
| butyric acid | - | 0 6 | acetic, buttery, cheesy, fruity, sharp | |
| caramel furanone | - | 0 6 | burnt, caramellic, coffee, maple, sugar, sweet | |
| (S)-(+)-carvone | - | 0 6 | bready, caraway, minty, spicy | |
| cashmeran | - | 0 5 | clean, musk, spicy, woody | |
| coffee difuran | - | 0 6 | cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty | |
| cosmone | - | 0 5 | ambergris, animal, anisic, cloth, fatty, laundered, musk, powdery, woody | |
| cyclodecanone | - | 0 5 | ||
| cyclohexanone | - | 0 5 | acetone, minty | |
| cyclopentadecane | - | 0 5 | ||
| cyclopentadecanone | - | 0 5 | animal, greasy, musk, natural, powdery | |
| cycloundecanone | - | 0 5 | ||
| beta-damascone | - | 0 6 | berry, currant, floral, fruity, honey, plum, rose, tobacco | |
| dimethyl disulfide | - | 0 6 | cabbage, onion, sulfurous, vegetable | |
| 2-ethyl fenchol | - | 0 6 | camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea | |
| ethyl vanillin | - | 0 6 | caramellic, creamy, sweet, vanilla | |
| eugenol | - | 0 6 | clove, spicy, sweet, woody | |
| eugenyl acetate | - | 0 6 | carnation, clove, floral, fresh, malty, spicy, sweet, woody | |
| galaxolide | - | 0 5 | floral, musk, sweet | |
| globanone | - | 0 5 | animal, balsamic, cloth, dry, floral, laundered, musk, tobacco, waxy | |
| habanolide | - | 0 5 | animal, cloth, dry, laundered, metallic, musk, powdery, sweet, tropical, waxy | |
| helvetolide | - | 0 5 | ambrette, floral, fruity, musk, pear, woody | |
| 2-heptanone | - | 0 6 | banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody | |
| isobutylamine | - | 0 6 | cheesy, fishy | |
| d-limonene | - | 0 6 | citrus, fresh, orange, sweet | |
| linalool | - | 0 6 | blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody | |
| lyral | - | 0 6 | aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody | |
| (+)-menthol | - | 0 6 | cooling, mentholic, minty | |
| methyl furfuryl disulfide | - | 0 6 | alliaceous, coffee, meaty, roasted, sulfurous | |
| methyl salicylate | - | 0 6 | minty, wintergreen | |
| 3-methylcyclotetradecanone | - | 0 5 | ||
| muscenone | - | 0 5 | animal, musk, soapy | |
| muscone | - | 0 5 | animal, fatty, musk, natural, powdery, sweet | |
| musk ketone | - | 0 5 | dry, fatty, floral, musk, powdery, soapy | |
| 1-nonanol | - | 0 6 | aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet | |
| octanethiol | - | 0 6 | sulfurous | |
| octyl octanoate | - | 0 6 | coconut, fruity, oily | |
| oxacyclohexan-2-one | - | 0 5 | ||
| pelargonic acid | - | 0 6 | cheesy, dairy, dirty, waxy | |
| 2-pentadecanone | - | 0 5 | burnt, celery, fatty, fresh, jasmine, oily, waxy | |
| 8-pentadecanone | - | 0 5 | ||
| pentanol | - | 0 6 | balsamic, fermented, fusel, oily, sweet | |
| propanal | - | 0 6 | alcoholic, cocoa, earthy, nutty, whiskey, winey | |
| propionic acid | - | 0 6 | acidic, cheesy, pungent, vinegar | |
| pyrazine | - | 0 6 | pungent, sweet, corn, roasted, hazelnut, barley | |
| quinoline | - | 0 6 | earthy, medicinal, musty, rubbery, tobacco | |
| terpinyl acetate | - | 0 6 | bergamot, citrus, herbal, lavender, lime | |
| tonalide | - | 0 5 | amber, ambrette, fruity, musk, powdery, sweet |
1.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.
2.) Jeremy F. McRae, Joel D. Mainland, Sara R. Jaeger, Kaylin A. Adipietro, Hiroaki Matsunami, and Richard D. Newcomb Genetic Variation in the Odorant Receptor OR2J3 Is Associated with the Ability to Detect the "Grassy" Smelling Odor, cis-3-hexen-1-ol Chem. Senses 37: 585–593, 2012 doi:10.1093/chemse/bjs049
3.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
4.) Fukutani, Y., Koshizawa, T., & Yohda, M. (2021). Application of Vapor Phase Stimulation Method for Screening of Human Odorant Receptors Responding to Cinnamaldehyde. Sensors and Materials, 33(12), 4203-4210.
5.) Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection Narumi Sato-Akuhara, Nao Horio, Aya Kato-Namba, Keiichi Yoshikawa, Yoshihito Niimura, Sayoko Ihara, Mika Shirasu, Kazushige Touhara Journal of Neuroscience 20 April 2016, 36 (16) 4482-4491; DOI: 10.1523/JNEUROSCI.3259-15.2016
6.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
7.) Aya Kato, Naoko Saito (2018) Search method for odor control agent JP6422665B2
8.) Saito N, Yamano E, Ishii A, Tanaka M, Nakamura J, et al. (2018) Involvement of the olfactory system in the induction of anti-fatigue effects by odorants. PLOS ONE 13(3): e0195263. https://doi.org/10.1371/journal.pone.0195263
9.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.
10.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147