Olfactory Receptor family 4 subfamily K member 5.
Estimated Expression: 61% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MDKSNSSVVS EFVLLGLCSS QKLQLFYFCF FSVLYTVIVL GNLLIILTVT SDTSLHSPMY FLLGNLSFVD ICQASFATPK MIADFLSAHE TISFSGCIAQ 110 120 130 140 150 160 170 180 190 200 IFFIHLFTGG EMVLLVSMAY DRYVAICKPL YYVVIMSRRT CTVLVMISWA VSLVHTLSQL SFTVNLPFCG PNVVDSFFCD LPRVTKLACL DSYIIEILIV 210 220 230 240 250 260 270 280 290 300 VNSGILSLST FSLLVSSYII ILVTVWLKSS AAMAKAFSTL ASHIAVVILF FGPCIFIYVW PFTISPLDKF LAIFYTVFTP VLNPIIYTLR NRDMKAAVRK 310 320 330 IVNHYLRPRR ISEMSLVVRT SFH
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 F K D L T I Y S D T F I T E H L F L K Q S I A L F P W V I E I S L Q S S F S D A I F L Q V T Y F Y I F V V I L L T H A I C G M K P T F C F Y P T F I C P G G S N V L S V F I Q A F S V S F P N L V F F L L S L I A W S L H I F A Q C I V T Y L Y I I I V V A F T S I M V L G T F D V F L V I I H S V L L S V T C V M E G S L N G L L N G A L T S Y S S T R R S V L L L L F L I I F A K L I I I Y A M S Y M P S S T V T A M A A V T V Y R D D L W C I A V UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| eugenol | -4.08 1 | 0.4813 1 | clove, spicy, sweet, woody | |
| cedramber | - | 1.9231 2 | woody, dry, cedar, ambergris, earthy, vetiver | |
| ysamber K | - | 1.9231 2 | dry, woody, vetiver, amber, powdery, musk, fruity | |
| hexanal | - | 0.5 3 | aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty |
1.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
2.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).
3.) Ojiro I, Katsuyama H, Kaneko R, Ogasawara S, Murata T, Terada Y, et al. (2024) Enhancement of transcription efficiency by TAR-Tat system increases the functional expression of human olfactory receptors. PLoS ONE 19(6): e0306029. https://doi.org/10.1371/journal.pone.0306029