OR4K5

Olfactory Receptor family 4 subfamily K member 5.

Estimated Expression: 61% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MDKSNSSVVS EFVLLGLCSS QKLQLFYFCF FSVLYTVIVL GNLLIILTVT SDTSLHSPMY FLLGNLSFVD ICQASFATPK MIADFLSAHE TISFSGCIAQ 

       110        120        130        140        150        160        170        180        190        200 
IFFIHLFTGG EMVLLVSMAY DRYVAICKPL YYVVIMSRRT CTVLVMISWA VSLVHTLSQL SFTVNLPFCG PNVVDSFFCD LPRVTKLACL DSYIIEILIV 

       210        220        230        240        250        260        270        280        290        300 
VNSGILSLST FSLLVSSYII ILVTVWLKSS AAMAKAFSTL ASHIAVVILF FGPCIFIYVW PFTISPLDKF LAIFYTVFTP VLNPIIYTLR NRDMKAAVRK 

       310        320        330 
IVNHYLRPRR ISEMSLVVRT SFH

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


L F K D       I   I Y S D     T F   S I T E      L F  L K Q S  
 F I A   T F P W   I E I   S L Q S   G S F    D A I    F L Q   
F V T Y   V Y I   V V I L   L T H   Q A I C  M K P T  F C F Y  
 V P T   F I C P   G S N   V L S V   F F I    A F S    V S F   
I P N L   G F F   L S L I   A W S   F L H I  A Q C I  V T Y L  
 T Y I   L I V V   F T S   I M V L   G G T    D V F    L V I   
          A I H   V L L S   V T C   L V M E  S L N G  L L N G  
         S A L T   Y S S   T R R S   S V L    L L F    L I I   
          S F A   L I I I           D Y A M  Y M P S  S T V T  
         K A M A   V T V             V Y R                 D   
                      L W           K C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB

Odorant	EC₅₀	Adjusted Top	Aroma Notes
eugenol	-4.08 ¹	0.4813 ¹	clove, spicy, sweet, woody
cedramber	-	1.9231 ²	woody, dry, cedar, ambergris, earthy, vetiver
ysamber K	-	1.9231 ²	dry, woody, vetiver, amber, powdery, musk, fruity
hexanal	-	0.5 ³	aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty

1.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

2.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).

3.) Ojiro I, Katsuyama H, Kaneko R, Ogasawara S, Murata T, Terada Y, et al. (2024) Enhancement of transcription efficiency by TAR-Tat system increases the functional expression of human olfactory receptors. PLoS ONE 19(6): e0306029. https://doi.org/10.1371/journal.pone.0306029

Prot.	Sim.	Expr.	2.53	3.29	3.32	3.33	3.36	3.37	3.40	3.41	4.53	4.56	4.57	4.60	45.49	45.51	45.52	45.53	5.39	5.42	5.43	5.46	5.47	6.48	6.51	6.55	6.59	7.38	7.39	7.41	7.42
OR4K5	100	61%	Q	I	I	H	T	G	M	V	S	H	T	Q	F	D	L	P	I	N	S	L	S	F	C	Y	P	A	I	Y	T
OR4K15	92	42%	V	I	V	H	T	G	M	V	G	H	T	Q	F	D	L	P	I	D	S	L	S	F	C	Y	P	A	V	Y	T
OR4K17	88	84%	L	I	L	H	G	G	M	V	G	H	S	Q	F	D	L	P	I	N	S	I	S	F	C	Y	P	A	V	Y	T
OR4F4	88	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4F5	88	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4F17	88	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4K14	84	80%	L	I	L	H	G	G	M	V	G	H	S	Q	F	D	L	P	M	D	S	L	S	F	C	Y	P	S	V	Y	T
OR4L1	84	11%	L	M	M	H	G	G	M	T	G	H	S	Q	F	D	L	P	V	D	S	L	S	F	C	Y	P	A	V	Y	T
OR4K2	84	100%	L	I	L	H	T	G	I	I	G	H	S	Q	F	D	L	P	M	T	S	I	A	F	C	Y	P	S	V	Y	T
OR4K13	84	96%	L	M	M	H	G	G	M	M	G	H	S	Q	F	D	L	P	V	D	S	L	S	F	C	Y	P	S	V	Y	T
OR4Q2	84		Y	L	L	H	G	A	M	F	G	H	S	Q	F	D	V	P	M	N	S	I	S	F	C	Y	F	S	V	Y	N
OR4D5	83	80%	Y	L	F	H	G	G	I	F	G	H	S	Q	Y	D	V	P	M	N	N	V	T	F	C	Y	P	S	V	Y	T
OR4B1	83	69%	Y	I	F	H	G	V	I	L	G	H	S	Q	F	D	L	Q	V	N	S	F	S	F	A	Y	P	A	V	Y	T
OR4N2	83	73%	Y	L	L	H	G	G	G	L	G	H	S	Q	F	D	V	P	M	N	S	M	T	F	G	Y	P	S	L	H	T
OR4Q3	82	92%	L	I	L	H	G	A	M	F	G	H	S	Q	Y	D	V	P	V	N	S	L	S	F	C	Y	F	S	L	Y	T
OR4C3	82	34%	Y	L	A	H	G	G	I	I	G	H	S	Q	A	D	L	Y	V	N	S	I	C	F	C	Y	P	A	L	Y	G
OR4C13	82	7%	Y	V	E	H	R	G	V	I	G	H	A	Q	M	D	L	Y	I	N	S	I	C	F	C	Y	P	A	V	Y	T
OR4E2	82	96%	H	L	L	H	A	C	I	F	G	H	S	Q	F	D	V	P	I	N	S	I	S	F	C	Y	P	S	V	Y	T
OR4F6	82		F	I	I	H	G	G	M	V	G	H	S	Q	F	D	L	P	V	N	S	I	S	F	L	Y	P	A	I	D	A
OR4D9	81	100%	F	M	F	H	G	G	V	F	G	H	S	Q	Y	D	V	P	M	N	N	V	S	F	C	Y	P	S	V	F	T
OR4D11	81	34%	F	I	F	H	G	G	I	F	G	H	S	Q	Y	D	V	P	M	N	N	V	T	F	C	Y	P	S	V	F	T
OR4K1	81		Q	I	L	H	V	G	M	M	G	H	S	H	F	D	L	P	T	N	S	I	S	F	C	Y	P	S	V	Y	T
OR4N5	81	96%	Y	L	L	H	G	A	M	F	G	H	S	Q	F	D	V	P	M	N	S	L	S	F	A	Y	F	S	L	H	T
OR4D1	81	100%	Y	I	F	H	G	G	V	F	G	H	S	Q	Y	D	V	P	M	N	S	L	V	F	C	Y	P	S	I	Y	T
OR4C11	80	69%	F	V	L	H	G	C	I	F	S	H	S	Q	C	D	L	Q	L	N	S	I	C	F	C	Y	P	A	V	Y	T
OR4X2	80	53%	Y	L	L	H	G	G	I	F	G	H	S	Q	F	D	L	V	I	N	G	L	S	F	C	S	S	A	V	Y	T
OR4C16	80	19%	L	V	S	H	G	C	I	F	S	H	S	Q	F	D	L	Q	L	N	S	I	C	F	C	Y	L	A	V	Y	T

Active model:	text	3D	download
Inactive model:	text	3D	download
Active dock:	text	3D	download
Inactive dock:	text	3D	download
JSON entry:	text		download

primaryodors.org

Olfactory Receptor family 4 subfamily K member 5.

Estimated Expression: 61% of the population.

Sequence:

Transmembrane Helices: