☰

Olfactory Receptor family 4 subfamily D member 11.

Estimated Expression: 34% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MELGNVTRVK EFIFLGLTQS QDQSLVLFLF LCLVYMTTLL GNLLIMVTVT CESRLHTPMY FLLRNLAILD ICFSSTTAPK VLLDLLSKKK TISYTSCMTQ 

       110        120        130        140        150        160        170        180        190        200 
IFLFHLLGGA DIFSLSVMAF DCYMAISKPL HYVTIMSRGQ CTALISASWM GGFVHSIVQI SLLLPLPFCG PNVLDTFYCD VPQVLKLTCT DTFALEFLMI 

       210        220        230        240        250        260        270        280        290        300 
SNNGLVTTLW FIFLLVSYTV ILMTLRSQAG GGRRKAISTC TSHITVVTLH FVPCIYVYAR PFTALPTEKA ISVTFTVISP LLNPLIYTLR NQEMKSAMRR 

       310        320 
LKRRLVPSER E

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


I A K E       A   A F T D     L L   S I T K      L L  Q D Q S  
 T V S   T F P R   F E L   S I Q V   S T Y    D L L    V L S   
I V T F   A Y V   S I M L   I S H   Q T M C  V K P A  F L F L  
 L P S   Y I C P   G N N   V F G G   L F I    T T S    L C L   
L P N L   V F H   T T V L   M W S   L L H F  S F C I  T M Y V  
 T Y I   L T V V   F W L   A S I L   A G G    D L I    L L T   
          T I H   L L F I   A T C   S F I D  A L N R  L L N G  
         S T C T   Y S V   Q G R S   V S L    L L F    V M I   
          S I A   L I V T           D F A M  Y M P T  C T V T  
         K R R G   L T M             M Y C                 E   
                      S R           K S I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
2-ethyl-1-hexanol - 10 1  citrus, fresh, floral, oily, sweet, fatty, fruity
beta-ionone -3.1 2 2.1053 2  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
2-ethyl-1-butanol - 1.5 1  sweet, musty, alcoholic
hexanal - 1.5 1  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
2-ethyl hexanal - 0 1  
2-ethyl hexanoic acid - 0 1  
heptanal - 0 1  aldehydic, cognac, fatty, fresh, green, herbal, ozone

1.) Cho, S.W., Ko, H.J. & Park, T.H. Identification of a Lung Cancer Biomarker Using a Cancer Cell Line and Screening of Olfactory Receptors for Biomarker Detection. Biotechnol Bioproc E 26, 55–62 (2021).

2.) S.R. Jaeger, J.F. McRae, C.M. Bava, M.K. Beresford, D. Hunter, Y. Jia, S.L. Chheang, D. Jin, M. Peng, J.C. Gamble et al, A Mendelian Trait for Olfactory Sensitivity Affects Odor Experience and Food Selection, Curr. Biol. 23 (2013) 1601-1605.
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR4D11100 34%F I F H G G I F G H S Q Y D V P M N N V T F C Y P S V F T
OR4D999 100%F M F H G G V F G H S Q Y D V P M N N V S F C Y P S V F T
OR4D599 80%Y L F H G G I F G H S Q Y D V P M N N V T F C Y P S V Y T
OR4D1096 96%F M F H G G V F G H S Q Y D V H M N N L T F C Y P S V F T
OR4Q295Y L L H G A M F G H S Q F D V P M N S I S F C Y F S V Y N
OR4Q395 92%L I L H G A M F G H S Q Y D V P V N S L S F C Y F S L Y T
OR4D195 100%Y I F H G G V F G H S Q Y D V P M N S L V F C Y P S I Y T
OR4K1494 80%L I L H G G M V G H S Q F D L P M D S L S F C Y P S V Y T
OR4D694 65%F I F H G G I F G H S Q Y Y V L M N N V T F C Y P S I N T
OR4K1394 96%L M M H G G M M G H S Q F D L P V D S L S F C Y P S V Y T
OR4E293 96%H L L H A C I F G H S Q F D V P I N S I S F C Y P S V Y T
OR4N293 73%Y L L H G G G L G H S Q F D V P M N S M T F G Y P S L H T
OR4N592 96%Y L L H G A M F G H S Q F D V P M N S L S F A Y F S L H T
OR4D291 96%F I F H G G V F G H S Q Y D V P K N S L D F S Y P S I H T
OR4F491 92%L I L H G G M V G H S Q Y D L P V N S L T F C Y P A V Y S
OR4F591 92%L I L H G G M V G H S Q Y D L P V N S L T F C Y P A V Y S
OR4F1791 92%L I L H G G M V G H S Q Y D L P V N S L T F C Y P A V Y S
OR4K1791 84%L I L H G G M V G H S Q F D L P I N S I S F C Y P A V Y T
OR4M189Y L L H G A M F G H S Q F D I T M S S I S F S Y P S V H T
OR4N489 34%Y L L H G G G L G H S Q F D V R M N S M T F A Y P S L H T
OR4A4788Y L E H G G V F G H S Q F D M Y V N G A C F C Y P S V Y T
OR4K288 100%L I L H T G I I G H S Q F D L P M T S I A F C Y P S V Y T
OR4L188 11%L M M H G G M T G H S Q F D L P V D S L S F C Y P A V Y T
OR4K388L M L H G G I V G H A Q F D L P M T S I A F C Y P S V Y T
OR4M287 92%Y L L H G A M F G H S Q F D I T M S S I S F S Y P S V N T
OR4A587 15%Y L D H G G V F G H S Q S D M H V N S I C F C Y P T V Y T
OR4A1687Y L E H G G V F G H S Q V D M Y V N G I C F C Y P T V Y S
OR4B187 69%Y I F H G V I L G H S Q F D L Q V N S F S F A Y P A V Y T
OR4K1587 42%V I V H T G M V G H T Q F D L P I D S L S F C Y P A V Y T
OR4A1585 15%Y L D H A G V I G H S Q L D L Y M N G I C F C Y P T V L T
OR4K185Q I L H V G M M G H S H F D L P T N S I S F C Y P S V Y T
OR4C385 34%Y L A H G G I I G H S Q A D L Y V N S I C F C Y P A L Y G
OR4X284 53%Y L L H G G I F G H S Q F D L V I N G L S F C S S A V Y T
OR4P484 57%Y L T H G G I F G H S Q F D V Y V N S I A F A Y V A L Y T
OR4F684F I I H G G M V G H S Q F D L P V N S I S F L Y P A I D A
OR10G883 57%F L F H G G C F G H S Q L D A P I T V V A F G Y G A V Y T
OR4C583S L E H G G I I G H A Q I D L F V N S M C F C Y P S V Y T
OR4X183 23%Y M L H G G A F G H S Q F D V H I N G I S F C Y C A V Y T
OR4C1582 69%F L E H A G V I G H S Q M D L Y V N S I C F C Y P A I Y I
OR4C1182 69%F V L H G C I F S H S Q C D L Q L N S I C F C Y P A V Y T
OR4F1582 92%F I S H G G M V G H S Q Y D L P V N S I S F L Y P A I D A
OR10G482 88%F L F H G S C F G H S Q F D A P I D I V A F C Y G A I Y T
OR4K581 61%Q I I H T G M V S H T Q F D L P I N S L S F C Y P A I Y T
OR4S281 57%Y L V H G C I F G H S Q F D V H V N S I A F C Y D A V Y T
OR10G981 46%F L F H G S C F G H S Q L D A P I D I V A F C Y G A I Y T
OR10G781 80%F L F H G S C F G H S Q F D A P I N I V A F G Y G A V Y T
OR4C4680 26%Y V E H G G G I G H A Q M D L N I N S I C F C Y P A I Y T
OR4C680 69%F L E H G G I I G H A Q I D L F V N S M C F C Y P A V D S
OR4F380 100%A I I H G G M V G H S Q Y D L P V N S I C F P Y P A I D A
OR4F2180 100%A I I H G G M V G H S Q Y D L P V N S I C F P Y P A I D A
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