☰

Olfactory Receptor family 4 subfamily Q member 3.

Estimated Expression: 92% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MKKEQDSNVT EFVLLGLSSS WELQLFLFLL FLFFYIAIVL GNLLIVVTVQ AHAHLLQSPM YYFLGHLSFI DLCLSCVTVP KMLGDFLQQG KSISFSGCLA 

       110        120        130        140        150        160        170        180        190        200 
QIYFLHFLGA SEMFLLTVMA YDRYVAICNP LRYLTVMNPQ LCLWLVLACW CGGFIHSIMQ VILVIQLPFC GPNELDNFYC DVPQVIKLAC MDTYVVEVLV 

       210        220        230        240        250        260        270        280        290        300 
IANSGLLSLV CFLVLLFSYA IILITLRTHF CQGQNKVFST CASHLTVVSL IFVPCVFIYL RPFCSFSVDK IFSLFYTVIT PMLNPLIYTL RNTDMKTAMK 

       310        320 
KLRIKPCGIP LPC

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


F I K D       S   V Y T D     V L   S I S K      L F  L E W S  
 F L S   C F P R   V E V   I V Q M   G S F    D G L    F L Q   
I V T Y   L Y I   A I V L   I S H   Q A L C  M K P V  L L F L  
 M P T   F V C P   G S N   I F G G   F Y I    T V C    F L F   
L P N L   V F I   L S L L   C W C   L F H L  S L C L  A I Y F  
 T Y I   L S V V   F C V   A L V L   S A G    D I F    L V I   
          T L H   L L V L   W L C   L F M E  S L H G  L L N G  
         S A C T   Y S F   L Q P N   V T L    L F Y    V V I   
          S F V   L I I A           D Y A M  Y M P S  A Q V T  
         K N Q G   L T I             V Y R                 H   
                      T R           N C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
diallyl disulfide - 10 1  alliaceous, garlic, metallic, onion
butyl anthranilate -6 2 1.4631 2  petitgrain, plum, sweet, grape, fruity, winey, floral, berry, powdery, chemical
eugenol -6 2 (agonist) 2  clove, spicy, sweet, woody
androstadienone -2.57 2 0.7303 2  animal, musky
benzyl salicylate - 2 1  balsamic, clean, herbal, oily, sweet

1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR4Q3100 92%L I L H G A M F G H S Q Y D V P V N S L S F C Y F S L Y T
OR4Q297Y L L H G A M F G H S Q F D V P M N S I S F C Y F S V Y N
OR4K1496 80%L I L H G G M V G H S Q F D L P M D S L S F C Y P S V Y T
OR4K1396 96%L M M H G G M M G H S Q F D L P V D S L S F C Y P S V Y T
OR4D595 80%Y L F H G G I F G H S Q Y D V P M N N V T F C Y P S V Y T
OR4N595 96%Y L L H G A M F G H S Q F D V P M N S L S F A Y F S L H T
OR4D995 100%F M F H G G V F G H S Q Y D V P M N N V S F C Y P S V F T
OR4D1195 34%F I F H G G I F G H S Q Y D V P M N N V T F C Y P S V F T
OR4F493 92%L I L H G G M V G H S Q Y D L P V N S L T F C Y P A V Y S
OR4F593 92%L I L H G G M V G H S Q Y D L P V N S L T F C Y P A V Y S
OR4F1793 92%L I L H G G M V G H S Q Y D L P V N S L T F C Y P A V Y S
OR4K1793 84%L I L H G G M V G H S Q F D L P I N S I S F C Y P A V Y T
OR4D192 100%Y I F H G G V F G H S Q Y D V P M N S L V F C Y P S I Y T
OR4E292 96%H L L H A C I F G H S Q F D V P I N S I S F C Y P S V Y T
OR4N292 73%Y L L H G G G L G H S Q F D V P M N S M T F G Y P S L H T
OR4D691 65%F I F H G G I F G H S Q Y Y V L M N N V T F C Y P S I N T
OR4D1091 96%F M F H G G V F G H S Q Y D V H M N N L T F C Y P S V F T
OR4L190 11%L M M H G G M T G H S Q F D L P V D S L S F C Y P A V Y T
OR4M189Y L L H G A M F G H S Q F D I T M S S I S F S Y P S V H T
OR4M289 92%Y L L H G A M F G H S Q F D I T M S S I S F S Y P S V N T
OR4K289 100%L I L H T G I I G H S Q F D L P M T S I A F C Y P S V Y T
OR4D289 96%F I F H G G V F G H S Q Y D V P K N S L D F S Y P S I H T
OR4K389L M L H G G I V G H A Q F D L P M T S I A F C Y P S V Y T
OR4N488 34%Y L L H G G G L G H S Q F D V R M N S M T F A Y P S L H T
OR4K1588 42%V I V H T G M V G H T Q F D L P I D S L S F C Y P A V Y T
OR4A4786Y L E H G G V F G H S Q F D M Y V N G A C F C Y P S V Y T
OR4K186Q I L H V G M M G H S H F D L P T N S I S F C Y P S V Y T
OR4A586 15%Y L D H G G V F G H S Q S D M H V N S I C F C Y P T V Y T
OR4A1685Y L E H G G V F G H S Q V D M Y V N G I C F C Y P T V Y S
OR4F685F I I H G G M V G H S Q F D L P V N S I S F L Y P A I D A
OR4B185 69%Y I F H G V I L G H S Q F D L Q V N S F S F A Y P A V Y T
OR4X285 53%Y L L H G G I F G H S Q F D L V I N G L S F C S S A V Y T
OR4C385 34%Y L A H G G I I G H S Q A D L Y V N S I C F C Y P A L Y G
OR4P483 57%Y L T H G G I F G H S Q F D V Y V N S I A F A Y V A L Y T
OR4X183 23%Y M L H G G A F G H S Q F D V H I N G I S F C Y C A V Y T
OR4A1583 15%Y L D H A G V I G H S Q L D L Y M N G I C F C Y P T V L T
OR4F383 100%A I I H G G M V G H S Q Y D L P V N S I C F P Y P A I D A
OR4F2183 100%A I I H G G M V G H S Q Y D L P V N S I C F P Y P A I D A
OR4K582 61%Q I I H T G M V S H T Q F D L P I N S L S F C Y P A I Y T
OR4C582S L E H G G I I G H A Q I D L F V N S M C F C Y P S V Y T
OR4F1582 92%F I S H G G M V G H S Q Y D L P V N S I S F L Y P A I D A
OR4S282 57%Y L V H G C I F G H S Q F D V H V N S I A F C Y D A V Y T
OR4C1581 69%F L E H A G V I G H S Q M D L Y V N S I C F C Y P A I Y I
OR4C1181 69%F V L H G C I F S H S Q C D L Q L N S I C F C Y P A V Y T
OR10G881 57%F L F H G G C F G H S Q L D A P I T V V A F G Y G A V Y T
OR4C1680 19%L V S H G C I F S H S Q F D L Q L N S I C F C Y L A V Y T
×
 
 

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