Olfactory Receptor family 56 subfamily A member 1.
Estimated Expression: 100% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MIQPMASPSN SSTVPVSEFL LICFPNFQSW QHWLSLPLSL LFLLAMGANT TLLITIQLEA SLHQPLYYLL SLLSLLDIVL CLTVIPKVLA IFWYDLRSIS 110 120 130 140 150 160 170 180 190 200 FPACFLQMFI MNSFLPMESC TFMVMAYDRY VAICHPLRYP SIITNQFVAK ASVFIVVRNA LLTAPIPILT SLLHYCGENV IENCICANLS VSRLSCDNFT 210 220 230 240 250 260 270 280 290 300 LNRIYQFVAG WTLLGSDLFL IFLSYTFILR AVLRFKAEGA AVKALSTCGS HFILILFFST ILLVVVLTNV ARKKVPMDIL ILLNVLHHLI PPALNPIVYG 310 320 VRTKEIKQGI QKLLQRGR
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 I D M P T L T F N T L S I S R W F W S Q F L I L L V V V I R N I P I P A P F I A L W H Q L V N L L L I V F Q Y A T L Q L F C V K P I P L S L L H H T S F F W G A L A N R I F M V T L L S L A P P I L I L G L L T V V I F S N M C L V I L L F L P N L I F H S L D S F V S A M P L D L L G M A G Y V I G C T F I L F K A V T C S E S L L S T T N A V S L A K Y S L F Q N T V M F L L Y I L L V A A L I F T D Y A M Y L P Q L Q I T G E A K V A R V Y R E F R L C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| 4-ethyloctanoic acid | - | 4 1 | goaty, lamb, mutton, fatty | |
| caprylic acid | - | (agonist) 2 | cheesy, fatty, oily, rancid, vegetable, waxy | |
| citronellic acid | - | (agonist) 2 | green, grassy, smoky, fatty, floral, waxy, citronella, vegetable, tobacco | |
| 2-methylundecanoic acid | - | (agonist) 2 | sour_milk, rancid, sickening | |
| butyric acid | - | 0 3 | sharp, acetic, cheesy, buttery, fruity, dairy, creamy | |
| delta-decalactone | - | 0 3 | coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet | |
| diacetyl | - | 0 3 | buttery, caramellic, creamy, pungent, sweet |
1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025
2.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1
3.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.