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SMILES:
CCCC(=O)[O-]

Aroma Description:
sharp, acetic, cheesy, buttery, fruity, dairy, creamy1

Receptor log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
OR51E1 -2.3 5, -5.47 8, -4.27 9 -  cheesy, sweaty, sour, acidic, rancid
OR51E2 -4.52 7, -2.5 11 2.6087 7, 2.5 10, 0.7 11  sour, vinegar, radish, sharp, cabbage, orris
OR51I2 -3.61 12 0.4167 10, 6.1 12  sour, cheesy, sweaty, acidic
OR52E1 -4.43 12 1.25 12  (insufficient data)
OR4F21 -4.69 2 0.4808 2  sharp, dairy, buttery, solvent, cheesy
OR52H1 - 4.5833 10  buttery, creamy, dairy, sharp
OR51D1 -4.13 2 0.1821 2, 0 10  dairy, lactonic, milky, peach, creamy, coconut, sharp
OR5D14 -4.09 2 0.1761 2  (insufficient data)
OR10A6 -4.1 2 0.1104 2  floral, cinnamyl, honey, rhubarb, neroli, hyacinth, cyclamen, balsamic, cinnamon, dirty
OR7G2 -3.88 2 0.1301 2  (insufficient data)
OR2T1 -3.81 2 0.131 2  eggy, sulfurous, cabbage, alliaceous, cheesy, creamy, sharp, garlic
OR52K2 - 2.9167 10  dairy, lactonic, milky, peach, creamy, coconut
OR52D1 - 2.8934 3, 0 10  anise, cheesy, rancid, orange, dairy, sour, sweet, tart, sharp, pineapple
OR52K1 - 2.5 10  dairy, lactonic, milky, peach, coconut, creamy
OR52L1 - 2.5 10  milky, dairy, lactonic, peach, coconut, creamy
OR56A4 - 0 5, 2.0833 10  cloth, laundered, aldehydic, orange_peel
OR52A1 - 2.0833 10  orange_peel, orris, dairy
OR52E4 - 2.0833 10  dairy, creamy, lactonic, milky, cheesy, sweaty, sharp, peach, sour, buttery
OR51B6 - 1.6667 10  dairy, lactonic, milky, peach, coconut, creamy
OR51M1 - 1.6667 10  dairy, lactonic, milky, creamy, peach, coconut, sharp
OR56A3 - 1.6667 10  clove, buttery, sharp, dairy
OR56B1 - 1.6667 10  buttery, creamy, dairy, caramellic, sharp
OR56B4 - 1.6667 10  dairy, lactonic, milky, peach, coconut, creamy
OR52N5 - 1.25 10  lactonic, milky, dairy, peach, coconut, creamy
OR51S1 - 0.8333 10  dairy, lactonic, milky, peach, fresh, coconut, creamy, musty
OR1G1 - 0.6091 3  waxy, tart, orange, sweet, aldehydic, medicinal, citrus, clean, fresh, anise
OR52W1 - 0.5833 10  buttery, caramellic, pungent, creamy
OR51Q1 - 0.4167 10  dairy, lactonic, milky, peach, coconut, ambrette, creamy
OR51T1 - 0.4167 10  spearmint, orangeflower, caraway, neroli, blueberry, minty, naphthyl, bois_de_rose, bready, hawthorn
OR52I2 - 0.4167 10  lactonic, milky, dairy, peach, coconut, creamy
OR7D4 - 0.2 6  animal
OR10G3 - 0 5   
OR10G7 - 0 5   
OR10J5 - 0 5   
OR11A1 - 0 5   
OR1C1 - 0 5   
OR2A25 - 0 5   
OR2J2 - 0 5   
OR2J3 - 0 5   
OR51L1 - 0 5, 0 10   
OR5K1 - 0 5   
OR8D1 - 0 5   
OR8K3 - 0 5   
OR51A2 - 0 10   
OR51A4 - 0 10   
OR51A7 - 0 10   
OR51B2 - 0 10   
OR51B4 - 0 10   
OR51B5 - 0 10   
OR51F1 - 0 10   
OR51G1 - 0 10   
OR51V1 - 0 10   
OR52A4 - 0 10   
OR52B2 - 0 10   
OR52B4 - 0 10   
OR52E2 - 0 10   
OR52E6 - 0 10   
OR52E8 - 0 10   
OR52N4 - 0 10   
OR56A1 - 0 10   
OR56A5 - 0 10   
OR2B11 - -0.3333 5   
OR2W1 - -0.9333 5   
OR1A1 - -1.2667 5   
OR5P3 - -2.5167 5   

SMILES:
CCCC(=O)[O-]

Aroma Description:
sharp, acetic, cheesy, buttery, fruity, dairy, creamy

Receptor Docking Score Correlated Perceptual Qualities

1.) The Good Scents Company

2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

3.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

4.) YOSHIFUMI FUJITA, TOMOKO TAKAHASHI, AKIKO SUZUKI, KAYO KAWASHIMA, FUTOSHI NARA & RYUTA KOISHI (2007) Deorphanization of Dresden G Protein-Coupled Receptor for an Odorant Receptor, Journal of Receptors and Signal Transduction, 27:4, 323-334, DOI: 10.1080/10799890701534180

5.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

6.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.

7.) Aisenberg, W., Huang, J., Zhu, W. et al. Defining an olfactory receptor function in airway smooth muscle cells. Sci Rep 6, 38231 (2016). https://doi.org/10.1038/srep38231

8.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

9.) Halperin Kuhns, V. L., Sanchez, J., Sarver, D. C., Khalil, Z., Rajkumar, P., Marr, K. A., & Pluznick, J. L. (2019). Characterizing novel olfactory receptors expressed in the murine renal cortex. American Journal of Physiology-Renal Physiology, 317(1), F172-F186.

10.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.

11.) Christian B. Billesbølle, Claire A. de March, Wijnand J. C. van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik. Structural basis of odorant recognition by a human odorant receptor. bioRxiv 2022.12.20.520951; doi: https://doi.org/10.1101/2022.12.20.520951

12.) Chatelain Pierre, Veithen Alex, Olfactory Receptors involved in the perception of sweat carboxylic acids and the use thereof. WO 2014/191047