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Olfactory Receptor family 56 subfamily A member 4.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MASPSNDSTA PVSEFLLICF PNFQSWQHWL SLPLSLLFLL AMGANTTLLI TIQLEASLHQ PLYYLLSLLS LLDIVLCLTV IPKVLAIFWF DLRSISFPAC 

       110        120        130        140        150        160        170        180        190        200 
FLQMFIMNSF LTMESCTFMV MAYDRYVAIC HPLRYPSIIT DQFVARAVVF VIARNAFVSL PVPMLSARLR YCAGNIIKNC ICSNLSVSKL SCDDITFNQL 

       210        220        230        240        250        260        270        280        290        300 
YQFVAGWTLL GSDLILIVIS YSFILKVVLR IKAEGAVAKA LSTCGSHFIL ILFFSTVLLV LVITNLARKR IPPDVPILLN ILHHLIPPAL NPIVYGVRTK 

       310        320 
EIKQGIQNLL KRL

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

S Q F N   I A L   A P F S       L   F T I D  I V L V  V D P P  
 H Q W   V K P I   L F C   M P V P   L Q N    L L V    L I P   
L S L W   V T L   I F M Q   L S V   V F Q Y  T S F F  L I N L  
 S L P   C L V I   S N M   F A N R   W G A    L I L    L H H   
L F L L   D L L   M T L F   A I V   G L L T  I F H S  A P P I  
 M A L   S L L S   C S E   F V V A   L D S    G C T    P N L   
T N A G   L L Y   V M F T   R A V   V I L I  S L A K  G Y V I  
 L L T   Y L P Q   Y A M   F Q D T   Y S I    A V A        V   
Q I T I           V Y R D           L I F S  G E A K           
                   C I A             V V K                     
                        H               R L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
undecanal -7 1 -  aldehydic, citrus, cloth, fatty, floral, green, laundered, soapy, waxy
aldehyde C-10 -4.41 2 3.1751 1  aldehydic, citrus, floral, orange, peel, sweet, waxy
butyric acid - 2.0833 3  acetic, buttery, cheesy, fruity, sharp
delta-decalactone - 1.25 3  coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet
aldehyde C-9 - 0 4  aldehydic, fatty, fresh, orange, orris, peel, peely, rose, waxy
allyl phenylacetate - 0 4  fruity, honey, rummy
amyl hexanoate - 0 4  apple, estery, fatty, fruity, green, pear, pineapple, sweet
androstenone - 0 4  animal, musky
l-arabinose - 0 4  
benzene - 0 4  
caramel furanone - 0 4  burnt, caramellic, coffee, maple, sugar, sweet
(S)-(+)-carvone - 0 4  bready, caraway, minty, spicy
citral - 0 4  citrus, lemon, sharp, sweet
coffee difuran - 0 4  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
coumarin - 0 4  coumarinic, hay, sweet, tonka
beta-damascone - 0 4  berry, currant, floral, fruity, honey, plum, rose, tobacco
diacetyl - 0 3  buttery, caramellic, creamy, pungent, sweet
dimethyl disulfide - 0 4  cabbage, onion, sulfurous, vegetable
2,4-DNT - 0 4  
2-ethyl fenchol - 0 4  camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl vanillin - 0 4  caramellic, creamy, sweet, vanilla
eugenol - 0 4  clove, spicy, sweet, woody
eugenyl acetate - 0 4  carnation, clove, floral, fresh, malty, spicy, sweet, woody
geranyl acetate - 0 4  floral, green, lavender, rose, waxy
helional - 0 4  cyclamen, fresh, green, hay, ozone, watery
2-heptanone - 0 4  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
cis-3-hexen-1-ol - 0 4  foliage, fresh, grassy, green, herbal, oily, vegetable
isobutylamine - 0 4  cheesy, fishy
d-limonene - 0 4  citrus, fresh, orange, sweet
linalool - 0 4  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
lyral - 0 4  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
(+)-menthol - 0 4  cooling, mentholic, minty
methyl eugenol - 0 4  carnation, cinnamon, clove, fresh, spicy, sweet, warm
methyl furfuryl disulfide - 0 4  alliaceous, coffee, meaty, roasted, sulfurous
methyl salicylate - 0 4  minty, wintergreen
1-nonanol - 0 4  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
1-octanol - 0 4  aldehydic, green, mushroom, orange, rose, waxy
octyl octanoate - 0 4  coconut, fruity, oily
pelargonic acid - 0 4  cheesy, dairy, dirty, waxy
pentanol - 0 4  balsamic, fermented, fusel, oily, sweet
propanal - 0 4  alcoholic, cocoa, earthy, nutty, whiskey, winey
propionic acid - 0 4  acidic, cheesy, pungent, vinegar
pyrazine - 0 4  pungent, sweet, corn, roasted, hazelnut, barley
quinoline - 0 4  earthy, medicinal, musty, rubbery, tobacco
terpinyl acetate - 0 4  bergamot, citrus, herbal, lavender, lime
butyl formate - -0.1667 4  brandy, fruity, plum, rummy
octanethiol - -0.2667 4  sulfurous

1.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

2.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

3.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.

4.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821