Olfactory Receptor family 1 subfamily A member 2.
Sequence:
10 20 30 40 50 60 70 80 90 100 MKKENQSFNL DFILLGVTSQ QEQNNVFFVI FLCIYPITLT GNLLIILAIC ADIRLHNPMY FLLANLSLVD IIFSSVTIPK VLANHLLGSK FISFGGCLMQ 110 120 130 140 150 160 170 180 190 200 MYFMIALAKA DSYTLAAMAY DRAVAISCPL HYTTIMSPRS CILLIAGSWV IGNTSALPHT LLTASLSFCG NQEVANFYCD IMPLLKLSCS DVHFNVKMMY 210 220 230 240 250 260 270 280 290 300 LGVGVFSLPL LCIIVSYVQV FSTVFQVPST KSLFKAFCTC GSHLTVVFLY YGTTMGMYFR PLTSYSPKDA VITVMYVAVT PALNPFIYSL RNWDMKAALQ 310 KLFSKRISS
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 Q E Q Q A L G G F S T L H V D S R K P S Y V N N V K P I M L C L T H P V N F F Y M G V A D I V F F T V S F Y M Q L A S Y M M K M T T M V T I C L F S F I I A I M T N G I V G L G Y Y L A V Y I P Y I D V L A K A L V W S S F V G F V V A P T V T L T S L N A Y S D G A I L L P L T L H S P N L L L N G L L F A A L T L I C I I C L G C T S Y I F L I I Y M P N Y A M S R P S Y S V C F A K C I A V A R D F V Q V F L S S I A V T S K T S P C F UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| (S)-(-)-citronellal | -6.62 1 | - | citrus, clean, herbal | |
| hydroxycitronellal | -6.41 1 | - | floral, green, lily, melon, sweet, tropical, waxy | |
| citral | -5.83 1 | - | citrus, lemon, sharp, sweet | |
| (-)-carveol | -5.78 2 | - | caraway, minty, spearmint | |
| nerolidol | - | 9 2 | citrus, floral, green, waxy, woody | |
| geraniol | -8 1 | 4.5 2 | citrus, floral, fruity, rose, sweet, waxy | |
| 1-octanol | -5.22 1 | - | aldehydic, green, mushroom, orange, rose, waxy | |
| helional | -6.47 1 | 6 2 | cyclamen, fresh, green, hay, ozone, watery | |
| (R)-(+)-citronellol | -5.09 2 | - | citronella, floral, leafy, oily, petal, rose | |
| heptanal | -6.77 1 | 4 2 | aldehydic, cognac, fatty, fresh, green, herbal, ozone | |
| aldehyde C-9 | -4.89 1 | 7 2 | aldehydic, fatty, fresh, orange, orris, peel, peely, rose, waxy | |
| 4-decenal | -5.78 1 | 5 2 | aldehydic, citrus, fatty, fresh, green, mandarin, orange, tangerine | |
| aldehyde C-8 | -6.37 1 | 4 2 | aldehydic, citrus, fatty, green, orange, peel, waxy | |
| l-limonene | - | 7 2 | herbal, peppery, pine, terpenic | |
| aldehyde C-10 | - | 5.5 2 | aldehydic, citrus, floral, orange, peel, sweet, waxy | |
| (R)-(+)-citronellal | - | 5 2 | citrus, fresh, herbal | |
| (E),(E)-2,4-decadienal | - | 5 2 | brothy, chicken, citrus, coriander, cucumber, fat, fatty, fried, melon, nutty, oily, pumpkin | |
| nerol | - | 5 2 | citrus, floral, fresh, green, lemon, lime, magnolia, natural, neroli, spicy, sweet, waxy | |
| trimethylamine | - | 5 2 | ammonia, fishy, prawn | |
| alpha-ionone | - | 4 2 | sweet, woody, floral, violet, orris, tropical, fruity | |
| 1-octen-3-one | - | 4 2 | earthy, metallic, mushroom | |
| (R)-(-)-carvone | - | 0 3 | herbal, minty, spearmint, sweet | |
| (S)-(+)-carvone | - | 0 3 | bready, caraway, minty, spicy | |
| citralva | - | 0 2 | aldehydic, citrus, lemon, metallic | |
| citronellic acid | - | 0 2 | citronella, fatty, floral, grassy, green, smoky, tobacco, vegetable, waxy | |
| (S)-(-)-citronellol | - | 0 1 | citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy | |
| hexanal | - | 0 1 | aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty |
1.) Silva Teixeira CS, Silva Ferreira AC, Cerqueira NM. Studying Haloanisoles Interaction with Olfactory Receptors. ACS Chem Neurosci. 2016 Jul 20;7(7):870-85. doi: 10.1021/acschemneuro.5b00335. Epub 2016 May 9. PMID: 27092849.
2.) Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J Struct Biol. 2007 Sep;159(3):400-12. doi: 10.1016/j.jsb.2007.04.013. Epub 2007 May 25. PMID: 17601748.
3.) Geithe C, Protze J, Kreuchwig F, Krause G, Krautwurst D. Structural determinants of a conserved enantiomer-selective carvone binding pocket in the human odorant receptor OR1A1. Cell Mol Life Sci. 2017 Nov;74(22):4209-4229. doi: 10.1007/s00018-017-2576-z. Epub 2017 Jun 27. PMID: 28656349.