SMILES:
CC(=CCCC(=CC=O)C)C
Aroma Description:
citrus, lemon, sharp, sweet1
| Receptor | log10 EC50 | Adj. Top | Antagonist? | Hypothesized PQ | Associated Perceptual Qualities (PQs) |
|---|---|---|---|---|---|
| OR1A1 | -5.79 6, -5.79 7 | 1 3 | leafy13 |
caraway, herbal, orange, cognac, weedy, spearmint, mushroom, hay, licorice, fatty | |
| OR1A2 | -5.83 6, -5.83 7 | - | orange, aldehydic, ozone, peel, citrus, spearmint, caraway, cyclamen, rose, waxy, cognac | ||
| OR1D2 | -4.52 8 | - | clean-bright13 |
rose, peach, bois_de_rose, lactonic, fresh, citrus, floral, coconut, waxy, creamy, blueberry, clean, ketonic, lime | |
| OR51A4 | -3.6 9 | - | lemon, sharp | ||
| OR52B2 | -3.3 9 | - | lemon, sharp, milky, lactonic | ||
| OR2W1 | -4.89 4 | - | allyl-demimetallic13 |
herbal, fatty, sweet, tart, banana, mushroom, orange, fresh, rancid, cherry, acacia, orangeflower | |
| OR1G1 | - | 5.0254 2 | waxy13 |
waxy, orange, tart, aldehydic, sweet, clean, citrus, fresh, anise, dusty, fruity, medicinal, fatty, oily | |
| OR2J3 | - | 4.8667 3 | jagged13 |
warm, candy, cinnamon, currant, hay, foliage | |
| OR52D1 | - | 3.5533 2 | ethereal13 |
cheesy, anise, orange, sour, rancid, sweet, dairy, sharp, pineapple, waxy, fruity, sweaty, banana | |
| OR2J2 | - | 2.6667 3 | smooth13 |
tart, carnation, warm, clove, sweet, hay, cinnamon | |
| OR7D4 | - | 0.2 5 | animalic5 |
animal | |
| OR10G3 | - | 0.0667 3 | creamy | vanilla, malty, chocolate, carnation, clove, creamy | |
| OR10G7 | - | 0 3 | |||
| OR10J5 | - | 0 3 | |||
| OR11A1 | - | 0 3 | |||
| OR1C1 | - | 0 3 | |||
| OR2A25 | - | 0 3 | |||
| OR2B11 | - | 0 3 | |||
| OR51E1 | - | 0 3 | |||
| OR51L1 | - | 0 3 | |||
| OR56A4 | - | 0 3 | |||
| OR8K3 | - | 0 3 | |||
| OR51B4 | - | 0 10 | |||
| OR8D1 | - | 0 3, -0.2308 11 | |||
| OR5P3 | - | -2.4333 3 | |||
| OR5K1 | - | 0.5 3, -14.3478 12 | pyrazinic14 |
hazelnut, nutty, roasted, peanut |
1.) The Good Scents Company
2.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002
3.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
4.) Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, et al. () Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome. PLoS ONE 9(4): e93037. doi:10.1371/journal.pone.0093037
5.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.
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7.) Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J Struct Biol. 2007 Sep;159(3):400-12. doi: 10.1016/j.jsb.2007.04.013. Epub 2007 May 25. PMID: 17601748.
8.) Veithen, A.; Wilin, F.; Philippeau, M.; Chatelain, P. OR1D2 is a broadly tuned human olfactory receptor. Chem. Senses 2015, 40, 262–263.
9.) Cong X, Ren W, Pacalon J, Xu R, Xu L, Li X, de March CA, Matsunami H, Yu H, Yu Y, Golebiowski J. Large-Scale G Protein-Coupled Olfactory Receptor-Ligand Pairing. ACS Cent Sci. 2022 Mar 23;8(3):379-387. doi: 10.1021/acscentsci.1c01495. Epub 2022 Feb 18. PMID: 35350604; PMCID: PMC8949627.
10.) Weber, Lea et al. “Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis.” PloS one vol. 12,3 e0172491. 8 Mar. 2017, doi:10.1371/journal.pone.0172491
11.) Aya NAMBA, Naoko Saito, Michiaki Inoue, Tsuyoshi TOYABE (2016) Inhibitor of odor caused by sotolone US9254248B2
12.) Aya Namba, Naoko Saito, Michiaki Inoue, Go Toriyabe (2018) Search method of odor control agent by furaneol JP6276555B2
13.) PrimaryOdors.org differential experiment.
14.) Marcinek, Patrick, et al. "An evolutionary conserved olfactory receptor for foodborne and semiochemical alkylpyrazines." The FASEB Journal 35.6 (2021): e21638.
References for aroma perceptual qualities should not be taken to indicate that the authors of outside studies necessarily assigned aroma notes to the neurons that receive input from any given receptor. Rather, the findings of outside studies often constitute the information on which we base our own perceptual quality assignments.