SMILES:
CC(=CCCC(=CC=O)C)C

Aroma Description:
sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal1

Receptor Expression log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
OR1A1 73 -5.79 6, -5.79 7 1 3, (agonist) 6, (agonist) 7  sweet, citrus, fresh, rose, herbal, waxy, orange, spearmint, floral, aldehydic
OR1A2 19 -5.83 6, -5.83 7 -  citrus, waxy, aldehydic, orange, fresh, orange_peel, tart, rose, sweet, floral
OR1D2 100 -4.52 8 -  rose, citrus, fresh, sweet, floral, waxy, fatty, bois_de_rose, peach, blueberry
OR51A4 84 -3.6 9 -  sharp, tart, juicy, lime, lemon
OR2W1 53 -4.89 4 -  sweet, tart, hay, fatty, coumarinic, orange, peony, cinnamon, herbal, tonka
OR1G1 61 - 5.0254 2  sweet, waxy, citrus, fresh, tart, orange, aldehydic, floral, rose, fatty
OR2J3 100 - 4.8667 3  tart, hay, sweet, foliage, passionfruit, cinnamon, warm, blackcurrant, coumarinic, candy
OR52B2 100 -3.3 9 -  cheesy, rancid, dairy, sour, fatty, creamy, milky, sharp, sweaty, tart
OR52D1 100 - 3.5533 2  dairy, cheesy, anise, milky, creamy, sour, sharp, peach, lactonic, rancid
OR2J2 92 - 2.6667 3  tart, sweet, carnation, hay, orange, warm, cinnamon, clove, coumarinic
OR7D4 96 - 0.2 5  animal, citrus, orange, peely, tart, aldehydic, blueberry
OR10G3 96 - 0.0667 3  vanilla, carnation
OR10G7 80 - 0 3   
OR10J5 84 - 0 3   
OR11A1 100 - 0 3   
OR1C1 100 - 0 3   
OR2A25 100 - 0 3   
OR2B11 100 - 0 3   
OR51E1 100 - 0 3   
OR51L1 88 - 0 3   
OR56A4 100 - 0 3   
OR8K3 92 - 0 3   
OR51B4 100 - 0 10   
OR7A17 100 - 0 15   
OR8D1 96 - 0 3, -0.2308 11   
OR6A2 100 -4 13 -1 13 Y 
OR5P3 100 - -2.4333 3   
TAAR5 ? -4.5 14 -4 14 Y 
OR5K1 100 - 0.5 3, -14.3478 12  hazelnut, nutty, peanut, roasted, carnation, cocoa, almond
 

SMILES:
CC(=CCCC(=CC=O)C)C

Aroma Description:
sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal

Receptor Expr.% Agonist? Dock Score Known agonist Correlated Perceptual Qualities

Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.

1.) The Good Scents Company

2.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

3.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

4.) Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, et al. () Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome. PLoS ONE 9(4): e93037. doi:10.1371/journal.pone.0093037

5.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.

6.) Silva Teixeira CS, Silva Ferreira AC, Cerqueira NM. Studying Haloanisoles Interaction with Olfactory Receptors. ACS Chem Neurosci. 2016 Jul 20;7(7):870-85. doi: 10.1021/acschemneuro.5b00335. Epub 2016 May 9. PMID: 27092849.

7.) Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J Struct Biol. 2007 Sep;159(3):400-12. doi: 10.1016/j.jsb.2007.04.013. Epub 2007 May 25. PMID: 17601748.

8.) Veithen, A.; Wilin, F.; Philippeau, M.; Chatelain, P. OR1D2 is a broadly tuned human olfactory receptor. Chem. Senses 2015, 40, 262–263.

9.) Cong X, Ren W, Pacalon J, Xu R, Xu L, Li X, de March CA, Matsunami H, Yu H, Yu Y, Golebiowski J. Large-Scale G Protein-Coupled Olfactory Receptor-Ligand Pairing. ACS Cent Sci. 2022 Mar 23;8(3):379-387. doi: 10.1021/acscentsci.1c01495. Epub 2022 Feb 18. PMID: 35350604; PMCID: PMC8949627.

10.) Weber, Lea et al. “Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis.” PloS one vol. 12,3 e0172491. 8 Mar. 2017, doi:10.1371/journal.pone.0172491

11.) Aya NAMBA, Naoko Saito, Michiaki Inoue, Tsuyoshi TOYABE (2016) Inhibitor of odor caused by sotolone US9254248B2

12.) Aya Namba, Naoko Saito, Michiaki Inoue, Go Toriyabe (2018) Search method of odor control agent by furaneol JP6276555B2

13.) Huiwen Ren, Ruijing Zhang, Haibo Zhang, Che Bian. Ecnomotopic olfactory receptors in metabolic regulation. Biomedicine & Pharmacotherapy 179 (2024) 117403

14.) Reina Kanemaki Kahori Kishigami, Mei Saito, Masafumi Yohda, and Yosuke Fukutani. Harnessing Odorant Receptor Activation to Suppress Real Malodor. Int. J. Mol. Sci. 2025, 26, 1566.

15.) Dan Takase, Tomohiro Shirai, Kensuke Misawa, Hiroaki Matsunami, Keiichi Yoshikawa, An odorant receptor for a key odor constituent of ambergris. Communications Biology | (2025)8:792. doi: 10.1038/s42003-025-08229-y

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