Olfactory Receptor family 52 subfamily L member 1.
Estimated Expression: 96% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MTLVSFFSFL SKPLIMLLSN SSWRLSQPSF LLVGIPGLEE SQHWIALPLG ILYLLALVGN VTILFIIWMD PSLHQSMYLF LSMLAAIDLV LASSTAPKAL 110 120 130 140 150 160 170 180 190 200 AVLLVHAHEI GYIVCLIQMF FIHAFSSMES GVLVAMALDC YVAICHPLHH STILHPGVIG CIGMVVLVRG LLLLIPFPIL LGKLIFCQAT IIGHAYCEHM 210 220 230 240 250 260 270 280 290 300 AVVKLACSET TVNRAYGLTM ALLVIGLDVL AIGVSYAHIL QAVLKVPGSE ARLKAFSTCG SHICVILVFY VPGIFSFLTH RFGHHVPHHV HVLLATWYLL 310 320 330 MPPALNPLVY GVKTQQIRQR VLRVFTQKD
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 V H H P G V T T E L L G I E H V L S E E L L V H F R H T A R N I P F P V I Y L V A W H Q W T A L L F S T L G Y I L L Q I L C L A K P P L A I L L Y F I G P L A M L L G R F F M A T S I G L A P P M V Y F G I V L V L V F A H I S A L V L L Y L P N L V L I V V D L V M G I M S S L D I V L A G Y V L C I H G I A L C G I V G S E A A L M T V N G V S G C T Y S V V G P H A V L S L F F L I S F A L I H A D L A M L Y M S M W I I K L R A V A Q V Y C D V K L C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| delta-decalactone | - | 10 1 | coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet | |
| valeric acid | -3.05 2 | 1.6 2 | acidic, cheesy, fruity, milky, sharp, sour, tobacco | |
| butyric acid | - | 2.5 1 | sharp, acetic, cheesy, buttery, fruity, dairy, creamy | |
| diacetyl | - | 0 1 | buttery, caramellic, creamy, pungent, sweet |
1.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.
2.) Chatelain Pierre, Veithen Alex, Olfactory Receptors involved in the perception of sweat carboxylic acids and the use thereof. WO 2014/191047
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR52L1 | 100 | 96% | L | M | I | H | S | S | S | G | G | L | L | F | Y | E | H | M | G | M | A | V | I | Y | G | F | R | A | T | Y | L |
| OR52R1 | 97 | 73% | L | V | I | H | S | S | S | G | G | W | V | F | Y | E | H | M | G | V | A | V | A | Y | A | F | R | A | N | Y | L |
| OR52E1 | 93 | L | M | I | H | T | G | S | A | P | F | V | F | Y | E | H | M | G | A | I | L | V | Y | A | F | R | A | N | Y | V | |
| OR52N2 | 91 | 100% | L | M | V | H | T | G | S | G | N | L | I | F | Y | D | H | M | G | V | A | I | G | Y | A | F | R | A | N | Y | L |
| OR52N5 | 91 | 92% | T | M | V | H | T | G | S | G | G | L | M | F | Y | D | H | M | G | V | A | I | G | Y | A | F | R | A | N | Y | L |
| OR52N4 | 90 | 100% | M | M | T | H | T | G | S | G | G | L | I | F | Y | D | H | M | G | V | A | I | W | Y | A | F | R | A | N | Y | L |
| OR52K2 | 90 | 80% | L | M | L | H | S | I | S | A | A | L | M | L | Y | E | H | M | G | V | A | I | V | Y | V | S | R | A | N | Y | L |
| OR52E2 | 89 | 42% | L | M | I | H | T | L | S | A | A | F | V | S | Y | E | H | M | G | A | I | L | V | Y | A | F | R | A | N | Y | V |
| OR52A1 | 88 | 88% | L | M | I | H | Q | G | S | G | A | L | V | C | Y | E | H | M | G | V | A | V | A | Y | A | F | R | S | S | Y | L |
| OR52E4 | 87 | 88% | L | M | I | H | T | G | T | V | N | L | V | F | Y | E | H | R | G | V | I | I | I | Y | A | F | R | A | N | Y | V |
| OR52N1 | 87 | 92% | M | M | V | H | T | G | S | G | G | L | V | S | Y | D | H | M | G | V | A | I | G | Y | A | F | H | A | N | Y | L |
| OR52K1 | 87 | 92% | L | M | L | H | S | I | S | A | A | L | M | L | Y | E | H | M | G | V | A | I | V | Y | V | S | R | A | I | Y | L |
| OR52P1 | 86 | A | M | I | H | C | M | S | T | G | L | M | C | Y | E | H | M | G | A | A | V | I | Y | A | F | R | A | N | Y | L | |
| OR52A5 | 86 | 92% | L | M | I | H | Q | A | S | G | A | L | I | S | Y | E | H | M | G | V | A | I | L | Y | A | F | R | L | L | N | L |
| OR52E8 | 86 | 84% | L | M | I | H | T | A | S | I | S | M | V | L | Y | E | H | M | G | N | I | L | L | F | A | F | R | A | N | Y | V |
| OR52D1 | 86 | 100% | L | M | V | H | Y | A | S | S | S | I | V | F | Y | E | H | M | G | V | A | A | M | Y | A | F | R | A | N | Y | V |
| OR51D1 | 81 | 65% | L | M | I | H | S | A | S | A | G | F | F | L | F | L | H | Q | G | I | I | V | M | Y | L | S | R | A | N | Y | L |
| OR52I2 | 81 | 100% | M | M | V | H | T | A | T | G | A | A | I | L | Y | E | H | I | S | G | S | M | V | Y | G | I | W | A | D | Y | V |
| OR52W1 | 80 | 100% | L | M | V | H | T | A | S | G | A | I | V | F | Y | A | H | M | G | L | S | I | S | Y | G | Y | R | S | N | Y | L |
| OR52E6 | 80 | 88% | L | M | I | H | T | V | S | I | S | M | V | L | Y | E | H | M | F | G | S | L | L | S | A | F | C | A | N | Y | V |