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Olfactory Receptor family 52 subfamily D member 1.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MSDSNLSDNH LPDTFFLTGI PGLEAAHFWI AIPFCAMYLV ALVGNAALIL VIAMDNALHA PMYLFLCLLS LTDLALSSTT VPKMLAILWL HAGEISFGGC 

       110        120        130        140        150        160        170        180        190        200 
LAQMFCVHSI YALESSILLA MAFDRYVAIC NPLRYTTILN HAVIGRIGFV GLFRSVAIVS PFIFLLRRLP YCGHRVMTHT YCEHMGIARL ACANITVNIV 

       210        220        230        240        250        260        270        280        290        300 
YGLTVALLAM GLDSILIAIS YGFILHAVFH LPSHDAQHKA LSTCGSHIGI ILVFYIPAFF SFLTHRFGHH EVPKHVHIFL ANLYVLVPPV LNPILYGART 

       310        320 
KEIRSRLLKL LHLGKTSI

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

A E L G   I A L   G G F S       L   V T I N       T   V H K P  
 F H A   M K P V   A L C   F I F P   V I N   L F S F   F I H   
I A I W   T T S   C F M Q   S V I   T L G Y   F A P   L N A L  
 C F P   S L A L   S H V   A V S R   L A V   I Y F V   L V Y   
L Y M A   D T L   L A Y I   F L G   G M A L   L I I   V P P V  
 L A V   S L L C   S S E   V F G I   S D L   G I H S   P N L   
A N G V   L F L   A L L I   R G I   A I L I   G C T   G Y L I  
 I L A   Y M P A   F A M   V A H N   Y S I   S L A K     R A   
A I V L           V Y R D           L I F G   H Q A            
                   C I A             V A H   D H S P           
                        N               H F                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
delta-decalactone - 8.3333 1  coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet
isoamyl acetate - 4.7716 2  banana, fruity, solvent, sweet
benzyl alcohol - 4.5685 2  floral, rose, phenolic, balsamic
6-methyl-5-hepten-2-one - 4.5685 2  apple, citrus, green, lemongrass, musty
1-nonanol - 4.5685 2  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
3-nonanone - 4.5685 2  floral, fresh, fruity, herbal, jasmine, leafy, spicy, sweet
2-decanone - 4.4162 2  cheesy, fatty, fermented, floral, orange, peach
2-nonanol - 4.4162 2  cheesy, citrus, creamy, fruity, green, orange, waxy
acetophenone - 4.3655 2  sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
benzothiazole - 4.264 2  coffee, cooked, meaty, nutty, rubbery, sulfurous, vegetable
methyl caprylate -1.09 3 6.599 2  aldehydic, green, herbal, orange, sweet, vegetable, waxy
butyl butyrate - 4.1624 2  banana, fruity, pineapple, sweet
ethyl oenanthate - 4.1624 2  cognac, fruity, pineapple, rummy, winey
estragole - 4.1117 2  anise, anisic, fennel, green, herbal, sassafrass, spicy, sweet
ethyl caproate - 4.0609 2  banana, fruity, green, pineapple, sweet, waxy
beta-ionone - 4.0609 2  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
oenanthic acid - 4.0609 2  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
citralva - 3.9594 2  aldehydic, citrus, lemon, metallic
caprylic acid - 3.9086 2  cheesy, fatty, oily, rancid, vegetable, waxy
3-octanone - 3.8071 2  fresh, herbal, lavender, mushroom, sweet
methyl oenanthate - 3.7563 2  berry, floral, fruity, green, orris, sweet, waxy
aldehyde C-8 - 3.5533 2  aldehydic, citrus, fatty, green, orange, peel, waxy
citral - 3.5533 2  citrus, lemon, sharp, sweet
(S)-methylthiobutanoate - 3.5025 2  cabbage, cheesy, eggy, fruit, garlic, metallic, musty, sulfurous, tomato
trans-anethole - 3.4518 2  anise, licorice, medicinal, sweet
thiazole - 3.4518 2  fishy, meaty, nutty
cyclohexanone - 3.1472 2  acetone, minty
anisole - 3.0964 2  phenolic, gasoline, ethereal, anise
safrole - 3.0964 2  anise, floral, sassafrass, spicy, sweet, warm, woody
benzaldehyde - 3.0457 2  sharp, sweet, bitter, almond, cherry
aldehyde C-10 - 2.9949 2  aldehydic, citrus, floral, orange, peel, sweet, waxy
trans-cinnamic acid - 2.9442 2  balsamic, cinnamyl, storax, sweet
galbanum pyrazine - 2.9442 2  green, pea, pepper
butyric acid - 2.8934 2  acetic, buttery, cheesy, fruity, sharp
ethyl butyrate - 2.8934 2  cognac, fruit, fruity, juicy, pineapple
3-hydroxybutan-2-one - 2.8934 2  buttery, creamy, dairy, fatty, milky, sweet
pelargonic acid - 2.8934 2  cheesy, dairy, dirty, waxy
isovaleric acid - 2.8426 2  cheesy, sour, sweaty, tropical
cinnamaldehyde - 2.7919 2  sweet, spicy, candy, cinnamon, warm
isobutyric acid - 2.7919 2  acidic, buttery, cheesy, dairy, rancid, sour
para-anisaldehyde - 2.6396 2  anisic, balsamic, floral, hawthorn, mimosa, powdery, sweet
caproic acid - 2.6396 2  cheesy, fatty, sour, sweaty
propionic acid - 2.5381 2  acidic, cheesy, pungent, vinegar
aldehyde C-9 - 2.3858 2  aldehydic, fatty, fresh, orange, orris, peel, peely, rose, waxy
helional - 2.3858 2  cyclamen, fresh, green, hay, ozone, watery
methyl salicylate - 2.132 2  minty, wintergreen
undecanal - 2.132 2  aldehydic, citrus, cloth, fatty, floral, green, laundered, soapy, waxy
dimethyl disulfide - 1.9289 2  cabbage, onion, sulfurous, vegetable
piperonyl acetone - 1.8782 2  berry, candy, cotton, floral, fruity, heliotrope, jammy, powdery, raspberry, sweet
lauric aldehyde - 1.7766 2  aldehydic, citrus, floral, green, soapy, waxy
methyl caproate - 1.7766 2  apricot, bacon, banana, ethereal, fruit, fruity, pineapple, strawberry, tropical
methyl decanoate - 1.7259 2  fermented, floral, fruity, oily, winey
eucalyptol - 1.6751 2  camphoraceous, eucalyptus, herbal
ethyl decanoate - 1.6244 2  apple, brandy, fruity, grape, oily, sweet, waxy
hedione - 1.6244 2  floral, green, jasmine, lactonic, natural, oily, tropical
2-nonanone - 1.6244 2  earthy, fresh, fruity, green, herbal, sweet, weedy
1-hexanol - 1.5228 2  alcoholic, ethereal, fruity, fusel, green, herbal, oily, pungent, sweet
2-octanone - 1.3706 2  earthy, herbal, natural, weedy, woody
4-octanol - 1.3198 2  
pyrazine - 1.3198 2  pungent, sweet, corn, roasted, hazelnut, barley
camphor - 1.269 2  camphoraceous
ethyl pelargonate - 1.269 2  fruity, natural, rose, rummy, tropical, waxy, winey
2-ethyl-1-hexanol - 1.269 2  citrus, fatty, floral, fresh, fruity, oily, sweet
geranyl acetate - 1.269 2  floral, green, lavender, rose, waxy
guaiacol - 1.269 2  phenolic, smoky, spicy, vanilla, woody
lyral - 1.269 2  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
2-methyl pyrazine - 1.2183 2  chocolate, cocoa, earthy, green, musty, nutty, peanut, roasted
methyl pelargonate - 1.1675 2  fruity, pear, sweet, tropical, waxy, winey
1-octanol - 1.1675 2  aldehydic, green, mushroom, orange, rose, waxy
(S)-(-)-citronellal - 1.1168 2  citrus, clean, herbal
citronellal natural - 1.1168 2  sweet, dry, floral, herbal, waxy, aldehydic, citrus
heptanal - 1.1168 2  aldehydic, cognac, fatty, fresh, green, herbal, ozone
1-heptanol - 1.1168 2  apple, banana, fruity, green, herbal, leafy, musty, peony, pungent, sweet, vegetable, violet, woody
2-heptanone - 1.0152 2  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
maltol - 1.0152 2  baked, bread, caramellic, cotton_candy, fruity, jammy, sweet
coumarin - 0.9645 2  coumarinic, hay, sweet, tonka
menthone - 0.9137 2  minty
ethyl vanillin - 0.7614 2  caramellic, creamy, sweet, vanilla
geraniol - 0.7614 2  citrus, floral, fruity, rose, sweet, waxy
2-octanol - 0.7614 2  earthy, fresh, green, herbal, spicy, woody
pyridine - 0.6599 2  ammoniacal, fishy, sour
ethyl isobutyrate - 0.6091 2  alcoholic, ethereal, fruity, fusel, rummy, sweet
quinoline - 0.6091 2  earthy, medicinal, musty, rubbery, tobacco
vanillin - 0.5076 2  chocolate, creamy, sweet, vanilla
indole - 0.4569 2  animal, fecal, floral, naphthyl
d-limonene - 0.4569 2  citrus, fresh, orange, sweet
capric acid - 0.2538 2  citrus, fatty, rancid, sour
(+)-menthol - 0.2538 2  cooling, mentholic, minty
gamma-decalactone - 0.203 2  buttery, coconut, fresh, oily, peach, sweet, waxy
1-decanol - 0.203 2  aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
1-dodecanol - 0.1015 2  aldehydic, coconut, earthy, fatty, honey, soapy, waxy
ethyl caprylate - 0.1015 2  apricot, banana, brandy, fruity, pear, sweet, waxy, winey
3-octanol - 0.1015 2  earthy, mushroom, herbal, melon, citrus, woody, spicy, minty, dairy, musty, creamy, waxy, fermented, green
lauric acid - 0.0761 2  bay, coconut, fatty
hexanal - 0.0508 2  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
thymol - 0.0508 2  camphoraceous, herbal, medicinal, phenolic, thyme
diacetyl - 0 1  buttery, caramellic, creamy, pungent, sweet

1.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.

2.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

3.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.