☰

Olfactory Receptor family 7 subfamily C member 1.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
METGNQTHAQ EFLLLGFSAT SEIQFILFGL FLSMYLVTFT GNLLIILAIC SDSHLHTPMY FFLSNLSFAD LCFTSTTVPK MLLNILTQNK FITYAGCLSQ 

       110        120        130        140        150        160        170        180        190        200 
IFFFTSFGCL DNLLLTVMAY DRFVAVCHPL HYTVIMNPQL CGLLVLGSWC ISVMGSLLET LTVLRLSFCT EMEIPHFFCD LLEVLKLACS DTFINNVVIY 

       210        220        230        240        250        260        270        280        290        300 
FATGVLGVIS FTGIFFSYYK IVFSILRISS AGRKHKAFST CGSHLSVVTL FYGTGFGVYL SSAATPSSRT SLVASVMYTM VTPMLNPFIY SLRNTDMKRA 

       310        320 
LGRLLSRATF FNGDITAGLS

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


S T R S    L Y V  I F T D     V T   T I F K      L I  I E S T  
 A V L    G F G    V N N   L T E L   G A Y    N L L    I F Q   
Y M V S  T G Y F  F Y I V   L S G   Q S L C  M K P V  L G F L  
 V M T    L T V    G T A   M V S I   F F I    T T S    S L F   
L M P T  V S L H  V G L V   C W S   F S T F  T F C L  V L Y M  
 F P N    S G C    F S I   G L V L   L C G    D A F    T F T   
L S Y I  T S F A  F I G T   L G C   L L N D  S L N S  L L N G  
     R    K H K    Y S F   L Q P N   V T L    L F F    L I I   
         R G A S  V I K Y           D Y A M  Y M P T  S C I A  
                   I S F             V F R                 D   
                    I R L           H C V A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
ambermax -5.64 1 -  amber, woody, cedarwood, ambergris
androstadienone -5 2 0.5061 2  animal, musky
androstenone -4.54 2 0.1833 2  animal, musky
timberol - (agonist) 1  dry, sawdust, woody, powdery, amber, sandalwood

1.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1

2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR7C1100 100%F I F T G C N L S G S E F D L L I A T L G Y G Y S S V Y T
OR7C292 53%F I F I G C N L S G S E F D P S M V T L G Y G Y S S V Y T
OR2D385 100%F I F L G C C A G V S D F E P P I M G I L Y G Y N S V Y T
OR5AN185 100%Y Y F S G L S C G A S Q F D M P T L T F G Y G Y S S V Y T
OR7G382F I V L V G N G S D A H F E L A V V T L G Y G Y S S V Y T
OR10AG181 65%Y M F L G G C L T V V E F D I P V V A F I F G Y K S L Y T
OR2D281 100%F L F L G C C A G V S D F E A P I M G I L Y A Y K S V Y A
OR6B381 88%Y L F S V C C V G I S K F D I S D L A I L Y L Y Q S V Y T
OR7G181 61%L I V L A G S C S D A Q F E V V I A S F G Y A Y S S V Y T
OR10K281 96%Y M F L G C S F G V A I F D I A I L C V L Y A Y Q S V Y T
OR6B280 92%Y L F S V C C V G I S K F D I S D L A I L Y L Y Q S A Y T
OR10A780 15%F M F F G S C F G V S Q F D G P A S T F I Y A Y K S L Y T
OR8K180 42%Y L F E I I L F S V S L Y D C I I F S N L Y L Y K S V Y T
OR9I180 96%Y F F T A G C F G G A R F D L P I F G V I F L Y S S V Y T
OR7A1080 73%F M F L V G N F S N S Q F E I N M A V L G Y C Y S S V Y T
OR10V180 76%Y M F V G G C V G L S L Y D M P L I S V L Y T Y S S V Y T
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