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Olfactory Receptor family 5 subfamily AN member 1.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MTGGGNITEI TYFILLGFSD FPRIIKVLFT IFLVIYITSL AWNLSLIVLI RMDSHLHTPM YFFLSNLSFI DVCYISSTVP KMLSNLLQEQ QTITFVGCII 

       110        120        130        140        150        160        170        180        190        200 
QYFIFSTMGL SESCLMTAMA YDRYAAICNP LLYSSIMSPT LCVWMVLGAY MTGLTASLFQ IGALLQLHFC GSNVIRHFFC DMPQLLILSC TDTFFVQVMT 

       210        220        230        240        250        260        270        280        290        300 
AILTMFFGIA SALVIMISYG YIGISIMKIT SAKGRSKAFN TCASHLTAVS LFYTSGIFVY LSSSSGGSSS FDRFASVFYT VVIPMLNPLI YSLRNKEIKD 

       310        320 
ALKRLQKRKC C

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

I R P F        L  G V F T     L A   F F T D       S   F S S S  
 V K I    N S L    I I C   G I Q F   V Q V   L Y V F   F R D   
I T F L  M K P V  I F Y Q   L S A   I A T M   I G S   F V S A  
 V L F    T S S    T S F   T L G T   M T L   T Y F L   V T Y   
T I Y I  I Y C V  S L G M   M Y A   I G F F   S V A   M P I V  
 A L S    D I F    C S E   G L V M   A S A   T L H S   P N L   
S L N W  S L N S  A T M L   W V C   M I V L   A C T   S Y I L  
 V I L    L F F    Y A M   L T P S   Y S I   N F A K       L   
  R I L  Y M P T  A Y R D           G I Y G   S R G            
                   C I A             I S I   K A S T           
                        N               K M                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
musk tibetene -7.48 1 9.4776 2  fatty, musk, powdery, sweet
musk ketone -6.8 1 10 2  dry, fatty, floral, musk, powdery, soapy
muscone -6.54 1 10 3  musk, animal, powdery
cyclopentadecanone -6.43 1 8.9552 2  animal, greasy, musk, natural, powdery
civetone -6.06 1 9.2857 1  clean, musk, dry, animal, sweet
velvione - 9.0299 2  dry, powdery, musk, amber, civet
cyclopentadecanol - 8.9552 2  musk
cosmone - 8.5 4  ambergris, animal, anisic, cloth, fatty, laundered, musk, powdery, woody
muscenone -6.58 1 6 4  animal, musk, soapy
musk xylene - 7.7612 2  dry, fatty, musk, soapy, sweet
habanolide -5.66 1 5.7143 1  animal, cloth, dry, laundered, metallic, musk, powdery, sweet, tropical, waxy
globanone - 7 4  animal, balsamic, cloth, dry, floral, laundered, musk, tobacco, waxy
ambrettolide -5.64 1 3.5714 1  sweet, soapy, musk, amber, fruity, berry
isomuscone -2.45 2 8.2836 2  animal, musk, powdery
galaxolide -6.45 1 1.4286 1  floral, musk, sweet
dihydrocivetone -2.66 2 3.7313 2  musk
ethylene brassylate -0.95 1 6.4286 1  ambrette, floral, musk, powdery, sweet, woody
thiacyclopentadecane-1-oxide -2.53 2 3.0597 2  musk
beta-ionone -2.8 5 1.0526 5  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
exaltolide - 2.3881 2  animal, fruity, musk, natural, powdery
3-methylcyclotetradecanone - 0.8 6  
oxacyclohexan-2-one - 0.16 6  
cashmeran - 0.0004 6  spicy, musk, woody, clean
cyclodecanone - 0.0004 6  
cyclohexanone - 0.0004 6  acetone, minty
cyclopentadecane - 0.0004 6  
cycloundecanone - 0.0004 6  
2-pentadecanone - 0.0004 6  burnt, celery, fatty, fresh, jasmine, oily, waxy
8-pentadecanone - 0.0004 6  
tonalide - 0.0004 6  amber, ambrette, fruity, musk, powdery, sweet
acetic acid - 0 4  sharp, pungent, sour, vinegar
acetophenone - 0 4  sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
amber butanol - 0 4  woody, amber, ambrette
amber xtreme - 0 4  animal, musk, woody, spicy
amberketal - 0 4  dry, amber, powdery, woody, musk
ambrinol - 0 4  amber, natural, musk, animal
ambroxide - 0 4  dry, amber, ambergris, paper, musk, woody, cedar, pine, green, seedy
benzoic acid - 0 4  balsamic, urine
benzyl propionate - 0 4  sweet, fruity, floral, banana, jasmin, balsamic, apple, jammy
boisambrene - 0 4  woody, cedar, ambergris, dry, dusty, amber
borneol - 0 4  pine, woody, camphoreous, peppery, earthy, minty, herbal, musty
p-t-butyl cyclohexanone - 0 4  woody, minty, patchouli, musk, leathery
calone - 0 4  fresh, watery, clean, melon, green, marine, ozone, phenolic
camphene - 0 4  woody, herbal, fir_needle
camphor - 0 4  camphoraceous
caproic acid - 0 4  cheesy, fatty, sour, sweaty
caprylic acid - 0 4  cheesy, fatty, oily, rancid, vegetable, waxy
(R)-(-)-carvone - 0 4  herbal, minty, spearmint, sweet
celestolide - 0 6  ambergris, animal, cedar, musk, woody
1,4-cineol - 0 4  cooling, pine, minty, camphoraceous, terpenic, green
claritone - 0 4  sweet, herbal, clary_sage, sage, bergamot, petitgrain, tropical, citrus
p-cresyl phenyl acetate - 0 4  animal, rose, honey, narcissus, lily, hyacinth
cyclododecanone - 0 4  
beta-damascone - 0 4  berry, currant, floral, fruity, honey, plum, rose, tobacco
gamma-decalactone - 0 4  fresh, oily, waxy, peach, coconut, buttery, sweet
decanal - 0 4  sweet, aldehydic, waxy, orange_peel, citrus, floral
1-decanol - 0 4  aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
delta-dodecalactone - 0 4  fresh, sweet, metallic, peach, oily, coconut, buttery, fatty, creamy, dairy, fruity, apricot, milky
1-dodecanol - 0 4  earthy, soapy, waxy, fatty, honey, coconut, clean, aldehydic, cilantro, watery, greasy
omega-dodecanolactam - 0 4  
fructone - 0 4  apple, fruity, green, plum, sweet, tropical, woody
geraniol - 0 4  citrus, floral, fruity, rose, sweet, waxy
helional - 0 4  cyclamen, fresh, green, hay, ozone, watery
helvetolide - 0 6  musk, ambrette, fruity, pear, woody, floral
hexanal - 0 4  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
1-hexanol - 0 4  ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
(Z)-3-hexen-1-ol - 0 4  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
(Z)-3-hexenyl hexanoate - 0 4  fruity, green, waxy, pear, winey, tropical, grassy, pineapple
Iso-E-Super - 0 4  ambergris, cedar, dry, ketonic, old_wood, phenolic, woody
isoamyl butyrate - 0 4  fruity, green, apricot, pear, banana
isoborneol - 0 4  balsamic, camphoraceous, herbal, woody
isobornyl acetate - 0 4  balsamic, camphoraceous, herbal, woody, sweet, citrus, soapy, terpenic, pine
isolongifolanone - 0 4  dry, woody, patchouli, cedar, earthy, tobacco, incense
isomenthone - 0 4  minty, cooling, peppermint, sweet
isovaleric acid - 0 4  cheesy, sour, sweaty, tropical
jasmolactone delta - 0 4  oily, fruity, coconut, floral, petal, jasmine, tuberose, peach, apricot
d-limonene - 0 4  citrus, orange, fresh, sweet
melonal - 0 4  fresh, ozone, melon, watermelon, sweet, clean, green
(1R,2S,5R)-(-)-menthol - 0 4  peppermint, cooling, mentholic, minty, camphoreous, clean
methyl cinnamate - 0 4  balsamic, cherry, strawberry, sweet
methyl nonyl acetaldehyde - 0 4  fresh, amber, aldehydic, mossy, citrus, tuberose, metallic, waxy, coumarinic
6-methyl quinoline - 0 4  leathery, tonka, castoreum, tobacco, civet, fecal
gamma-nonalactone - 0 4  buttery, coconut, creamy, oily, sweet, waxy
gamma-octalactone - 0 4  sweet, coconut, waxy, creamy, tonka, dairy, fatty
octanal - 0 4  aldehydic, citrus, fatty, green, orange, peel, waxy
1-octanol - 0 4  aldehydic, green, mushroom, orange, rose, waxy
oranger crystals - 0 4  sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
orris hexanone - 0 4  woody, dry, orris, earthy, camphoraceous
phenethyl acetate - 0 4  floral, fruity, honey, rose, sweet, tropical
phenylacetic acid - 0 4  sweet, honey, floral, honeysuckle, sour, waxy, civet
piperonyl acetone - 0 4  berry, candy, cotton, floral, fruity, heliotrope, jammy, powdery, raspberry, sweet
raspberry ketone - 0 4  berry, floral, jammy, raspberry, ripe, seedy, sweet, woody
romandolide - 0 4  musk, ambrette, fruity, berry
santaliff - 0 4  sandalwood, creamy, woody, milky, waxy, greasy, musk
(R)-(+)-sclareolide - 0 4  dry, paper, woody, ambergris, labdanum
styralyl acetate - 0 4  green, leafy, gardenia, rhubarb, musty
sulcatone - 0 4  citrus, green, musty, lemongrass, apple, ketonic, creamy, cheesy, banana, vegetable, green_bean
alpha-terpinene - 0 4  woody, terpenic, lemon, herbal, medicinal, citrus
tonka undecanone - 0 4  sweet, spicy, balsamic, tonka, woody, tobacco, green
gamma-undecalactone - 0 4  fruity, peach, creamy, fatty, lactonic, apricot, ketonic, coconut
valeric acid - 0 4  acidic, cheesy, fruity, milky, sharp, sour, tobacco
gamma-valerolactone - 0 4  herbal, sweet, warm, tobacco, cocoa, woody
woody cyclohexanone - 0 4  woody, old_wood, amber, tobacco, herbal
ysamber - 0 4  dry, woody, vetiver, amber, powdery, musk, fruity

1.) Omura M, Takabatake Y, Lempert E, Benjamin-Hong S, D'Hulst C, Feinstein P. A genetic platform for functionally profiling odorant receptors in olfactory cilia ex vivo. Sci Signal. 2022 Aug 9;15(746):eabm6112. doi: 10.1126/scisignal.abm6112. Epub 2022 Aug 9. PMID: 35944068.

2.) Ahmed, Lucky et al "Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds." Proceedings of the National Academy of Sciences 115.17 (2018): E3950-E3958. Web. 29 Aug. 2021.

3.) M. Shirasu, K. Yoshikawa, Y. Takai, A. Nakashima, H. Takeuchi, H. Sakano, K. Touhara, Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors, Neuron 81 (2014) 165-178.

4.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]

5.) S.R. Jaeger, J.F. McRae, C.M. Bava, M.K. Beresford, D. Hunter, Y. Jia, S.L. Chheang, D. Jin, M. Peng, J.C. Gamble et al, A Mendelian Trait for Olfactory Sensitivity Affects Odor Experience and Food Selection, Curr. Biol. 23 (2013) 1601-1605.

6.) Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection Narumi Sato-Akuhara, Nao Horio, Aya Kato-Namba, Keiichi Yoshikawa, Yoshihito Niimura, Sayoko Ihara, Mika Shirasu, Kazushige Touhara Journal of Neuroscience 20 April 2016, 36 (16) 4482-4491; DOI: 10.1523/JNEUROSCI.3259-15.2016
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