Sequence:
10 20 30 40 50 60 70 80 90 100 MRAVFIQGAE EHPAAFCYQV NGSCPRTVHT LGIQLVIYLA CAAGMLIIVL GNVFVAFAVS YFKALHTPTN FLLLSLALAD MFLGLLVLPL STIRSVESCW 110 120 130 140 150 160 170 180 190 200 FFGDFLCRLH TYLDTLFCLT SIFHLCFISI DRHCAICDPL LYPSKFTVRV ALRYILAGWG VPAAYTSLFL YTDVVETRLS QWLEEMPCVG SCQLLLNKFW 210 220 230 240 250 260 270 280 290 300 GWLNFPLFFV PCLIMISLYV KIFVVATRQA QQITTLSKSL AGAAKHERKA AKTLGIAVGI YLLCWLPFTI DTMVDSLLHF ITPPLVFDIF IWFAYFNSAC 310 320 330 340 NPIIYVFSYQ WFRKALKLTL SQKVFSPQTR TVDLYQE
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 G L T H V S L F D G D T F K N L V I F H L L Q I R I T L R C Y L F L W G W M T D I P P T L Y I V S L P L L Y T H S T Y P F N L T F P D F V L A C A V L L L T D A A P V F F L L W C L I F I L M G A G L F M T L C F G W G L C P V L Y I Y A F W V I I D A L F I S A L I Y I M I G V A I S N F V N G L A L S L F C L H R L A V Y L S G L T P N C A A V F L L F I S I V R V T F I K K A A K Y I I S V A F N T P T C H R D T A V V R E H F Y C I A A Q R K A A G D T I Q Q A L S T K S L T UniProt | I-TASSER | AlphaFold | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| trimethylamine | -7.52 1 | 10 1 | ammonia, fishy, prawn | |
| 3-iodo-thyronamine | - | 10 2 | ||
| N-methylpiperidine | -4 3 | 8.8 4 | ammonia, corn_chip, fishy, seafood, taco | |
| N,N-dimethylethylamine | -3.9 3 | 7.4 3 | ||
| eugenol | - | 1 5 | clove, spicy, sweet, woody | |
| ambroxide | - | 0 5 | amber, ambergris, cedar, dry, green, musk, paper, pine, seedy, woody | |
| cyclohexylamine | - | 0 4 | ||
| isoamylamine | - | 0 4 | ammoniacal | |
| 2-methylbutylamine | - | 0 4 | fishy | |
| beta-phenethylamine | - | 0 4 | ammoniacal, fishy | |
| tyramine | - | 0 4 | cooked, dirty, meaty, phenolic, rubbery | |
| coumarin | - | -1 5 | coumarinic, hay, sweet, tonka | |
| timberol | -5.7 5 | -3 5 | Y | amber, dry, powdery, sandalwood, sawdust, woody |
1.) Qian Li Deorphanization of Olfactory Trace Amine-Associated Receptors Chapter in Methods in Molecular Biology · June 2018 DOI: 10.1007/978-1-4939-8609-5_2
2.) Cichero E, Tonelli M (May 2017). "New insights into the structure of the trace amine-associated receptor 2: Homology modelling studies exploring the binding mode of 3-iodothyronamine". Chemical Biology & Drug Design. 89 (5): 790–796.
3.) Pacalon J, Belloir C, Fiorucci S, Briand L, Topin J. TAARs response to amine are largely affected by sequence variants. Submitted.
4.) Liberles SD, Buck LB. A second class of chemosensory receptors in the olfactory epithelium. Nature. 2006 Aug 10;442(7103):645-50. doi: 10.1038/nature05066. Epub 2006 Jul 30. PMID: 16878137.
5.) Wallrabenstein I, Singer M, Panten J, Hatt H, Gisselmann G. Timberol® Inhibits TAAR5-Mediated Responses to Trimethylamine and Influences the Olfactory Threshold in Humans. PLoS One. 2015;10(12):e0144704. Published 2015 Dec 18. doi:10.1371/journal.pone.0144704