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SMILES:
C1=CC=C(C=C1)C=CC=O

Aroma Description:
sweet, spicy, candy, cinnamon, warm1

Receptor Expression log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
OR2J3 100 -6 2 -  tart, hay, sweet, foliage, passionfruit, cinnamon, warm, blackcurrant, coumarinic, candy
OR2W1 53 - 10 6  sweet, tart, hay, fatty, coumarinic, orange, peony, cinnamon, herbal, tonka
OR1N1 96 -5 2 -  candy, warm, cinnamon, sweet
OR3A1 92 -5 2 -  cork_taint
OR10A5 100 - 7.5 6  candy, cinnamon, warm
OR1G1 61 -4 5 0.2538 3, (agonist) 5  sweet, waxy, citrus, fresh, tart, orange, aldehydic, floral, rose, fatty
OR10AG1 65 -4 2 -  candy, cinnamon, warm
OR2G2 38 -4 5 -  sweet, candy, berry, cinnamon, warm, vanilla, cotton_candy, strawberry
OR2M4 96 -4 5 -  fennel, naphthyl, anise, narcissus, sweet
OR2T10 92 -4 5 -  berry, bergamot, cotton_candy, lavender, strawberry, candy, lime, sweet, chocolate, warm
OR2T34 ? -4 5 -  fennel, candy, sweet, anise, apple, plum, ozone, warm, chocolate, cinnamon
OR10H2 69 -6 2 0.7916 2  watery, marine, candy, cinnamon, warm, vanilla, sweet, clean, spicy
OR2B11 100 -6 2 0.5195 2  hay, coumarinic, tonka, sweet, candy, cinnamon, rubbery, warm, orange, medicinal
OR2J2 92 - 5 6  tart, sweet, carnation, hay, orange, warm, cinnamon, clove, coumarinic
OR9G1 ? -4.75 2 0.3684 2  carnation, malty, clove, candy, warm
OR2C1 100 -4 2 1.4653 2  alliaceous, skunk, sulfurous, garlic, meaty, onion, roasted
OR52D1 100 - 2.7919 3  dairy, cheesy, anise, milky, creamy, sour, sharp, peach, lactonic, rancid
OR7D4 96 - 0.2 4  animal, citrus, orange, peely, tart, aldehydic, blueberry
TAAR5 ? -4.6 7 -6 7 Y 
 

SMILES:
C1=CC=C(C=C1)C=CC=O

Aroma Description:
sweet, spicy, candy, cinnamon, warm

Receptor Expr.% Agonist? Dock Score Known agonist Correlated Perceptual Qualities

Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.

1.) The Good Scents Company

2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

3.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

4.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.

5.) D. Gonzalez-Kristeller, J.B.P. do Nascimento, P.A.F. Galante, B. Malnic, Identification of agonists for a group of human odorant receptors, Front. Pharmacol. 6 (2015)

6.) Fukutani, Y., Koshizawa, T., & Yohda, M. (2021). Application of Vapor Phase Stimulation Method for Screening of Human Odorant Receptors Responding to Cinnamaldehyde. Sensors and Materials, 33(12), 4203-4210.

7.) Reina Kanemaki Kahori Kishigami, Mei Saito, Masafumi Yohda, and Yosuke Fukutani. Harnessing Odorant Receptor Activation to Suppress Real Malodor. Int. J. Mol. Sci. 2025, 26, 1566.
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