Olfactory Receptor family 2 subfamily M member 2.
Estimated Expression: 100% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MAWENQTFNS DFILLGIFNH SPPHTFLFFL VLGIFLVAFM GNSVMVLLIY LDTQLHTPMY FLLSQLSLMD LMLICTTVPK MAFNYLSGSK SISMAGCVTQ 110 120 130 140 150 160 170 180 190 200 IFFYISLSGS ECFLLAVMAY DRYIAICHPL RYTNLMNPKI CGLMATFSWI LGSTDGIIDA VATFSFSFCG SREIAHFFCE FPSLLILSCN DTSIFEEVIF 210 220 230 240 250 260 270 280 290 300 ICCIVMLVFP VAIIIASYAR VILAVIHMGS GEGRCKAFTT CSSHLMVVGM YYGAALFMYI RPTSDHSPTQ DKMVSVFYTI LTPMLNPLIY SLRNKEVTRA 310 320 330 340 350 FMKILGKGKS ESELPHKLYV LLFAKFFFLI SIFFYDVKIL ALIMYIA
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 D Q T P D I S T D T A S I S K L Y P P S H V M K S T P R E E F V A D I G A M N F A F T H Y F V S I Y M I F I V I G D Q T V C M K P V L F F L L I T F L A A I C C T S G L F F I T T C G L V L M P T G Y Y V L M V I W S L S I Y I L M L V L F I L P N M G V V V P F F T A M S G S D M L M F A Y I M L H I I I A L G C L F C E S L Q S V S N G S S C T Y S A I K P N V A L L L F L V M T F A I V R A D Y A M Y M P T L Y I L K C R G V A L I Y R D M H I H C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025
2.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.
3.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
4.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR2M2 | 100 | 100% | L | I | Y | I | S | G | C | F | G | D | G | D | F | E | F | P | I | C | C | M | L | Y | A | Y | T | S | V | Y | T |
| OR2M5 | 95 | 34% | L | I | Y | V | L | G | C | F | G | D | A | D | F | D | F | P | L | C | C | M | I | Y | G | Y | T | S | V | Y | T |
| OR2M3 | 92 | 100% | L | I | Y | T | L | G | C | F | G | D | G | D | F | D | F | P | L | C | C | M | I | Y | A | Y | T | S | V | Y | T |
| OR2T12 | 91 | 69% | L | I | L | P | G | G | C | F | G | D | G | Q | F | E | A | P | M | C | C | M | L | Y | G | Y | K | S | A | Y | T |
| OR2M7 | 91 | 34% | L | I | Y | I | L | G | C | F | G | D | G | D | C | D | F | P | I | C | C | M | L | Y | G | C | T | S | V | Y | T |
| OR2V2 | 90 | 96% | L | I | F | V | V | G | G | L | G | D | G | Q | F | E | M | L | I | C | C | M | L | Y | A | Y | R | S | I | Y | T |
| OR2T8 | 89 | 96% | L | I | L | P | G | G | C | F | G | D | G | Q | F | E | T | P | M | C | C | M | L | Y | A | Y | K | S | A | Y | T |
| OR2T33 | 89 | 92% | L | I | L | P | G | G | C | F | G | D | G | Q | F | E | T | P | M | C | C | M | L | Y | A | Y | K | S | A | Y | T |
| OR2M4 | 87 | 96% | L | I | Y | V | L | G | C | F | G | D | G | V | F | D | V | A | L | C | C | M | L | Y | A | Y | A | S | A | Y | T |
| OR2T4 | 86 | 80% | Y | M | Y | V | A | G | F | F | G | D | G | F | F | E | V | P | M | C | C | M | L | Y | A | Y | S | S | V | Y | T |
| OR2T5 | 86 | 100% | Y | M | Y | L | A | G | F | F | G | D | G | L | F | E | V | P | M | C | C | M | L | Y | A | Y | S | S | V | Y | T |
| OR2T29 | 86 | 100% | Y | M | Y | L | A | G | F | F | G | D | G | L | F | E | V | P | M | C | C | M | L | Y | A | Y | S | S | V | Y | T |
| OR2V1 | 86 | L | I | F | V | V | G | G | L | G | D | G | Q | F | E | V | Q | L | C | C | M | L | Y | A | Y | R | S | I | Y | T | |
| OR2T11 | 86 | 96% | F | I | Y | L | I | G | F | F | G | D | G | L | F | E | I | P | M | C | C | M | L | Y | A | Y | Q | S | A | Y | T |
| OR2T10 | 85 | 92% | Y | M | Y | L | G | G | C | C | G | D | G | L | F | E | V | P | M | C | C | M | L | Y | A | Y | S | S | F | Y | T |
| OR11L1 | 85 | 100% | Y | L | F | V | G | A | C | F | G | T | G | P | F | D | L | P | I | L | S | V | L | Y | M | Y | S | S | V | Y | T |
| OR2T3 | 82 | Y | M | Y | L | A | G | V | F | G | D | G | L | F | E | T | P | M | C | C | M | L | F | S | Y | S | S | A | Y | T | |
| OR2AG1 | 82 | 100% | F | M | A | L | G | G | D | L | A | S | A | Y | L | E | I | P | V | M | G | F | L | Y | A | Y | S | S | V | Y | T |
| OR2T2 | 81 | Y | I | Y | L | I | G | F | F | G | D | G | L | F | E | I | P | M | C | C | M | L | Y | A | N | H | S | A | Y | T | |
| OR2T6 | 81 | 92% | Y | C | Y | M | M | G | F | F | G | D | S | L | F | E | A | P | M | C | C | M | L | Y | A | Y | Q | S | A | Y | T |
| OR10A3 | 81 | 100% | F | M | I | L | G | G | C | F | G | V | A | Q | F | E | T | P | A | G | T | I | V | Y | A | Y | K | S | L | Y | T |
| OR2T35 | 80 | Y | I | L | L | I | G | F | F | G | D | G | L | F | E | I | P | M | C | C | M | L | Y | A | N | H | S | A | Y | T | |
| OR1J4 | 80 | 100% | L | M | F | I | T | D | N | F | S | N | A | H | F | D | L | V | I | V | G | V | I | Y | I | Y | S | S | V | Y | T |
| OR2D3 | 80 | 100% | F | I | F | L | G | C | C | A | G | V | S | D | F | E | P | P | I | M | G | I | L | Y | G | Y | N | S | V | Y | T |
| OR10A2 | 80 | F | M | F | F | G | V | C | F | G | V | A | Q | F | D | S | P | A | G | T | V | V | Y | L | Y | K | S | L | Y | T | |
| OR5G3 | 80 | S | M | F | G | E | A | C | F | A | S | T | H | F | D | I | F | L | L | A | I | G | Y | L | Y | S | S | L | Y | T | |
| OR10K2 | 80 | 96% | Y | M | F | L | G | C | S | F | G | V | A | I | F | D | I | A | I | L | C | V | L | Y | A | Y | Q | S | V | Y | T |
| OR2T1 | 80 | 69% | Y | H | Y | L | V | G | F | F | G | D | G | L | F | E | A | P | M | C | C | M | L | Y | A | Y | H | S | V | Y | T |
| OR2T27 | 80 | 96% | Y | H | Y | L | A | G | F | F | G | D | G | L | F | E | V | P | M | C | C | M | L | Y | A | Y | H | S | A | Y | T |