Olfactory Receptor family 2 subfamily T member 1.
Estimated Expression: 69% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MWQEYYFLNV FFPLLKVCCL TINSHVVILL PWECYHLIWK ILPYIGTTVG SMEEYNTSST DFTFMGLFNR KETSGLIFAI ISIIFFTALM ANGVMIFLIQ 110 120 130 140 150 160 170 180 190 200 TDLRLHTPMY FLLSHLSLID MMYISTIVPK MLVNYLLDQR TISFVGCTAQ HFLYLTLVGA EFFLLGLMAY DRYVAICNPL RYPVLMSRRV CWMIIAGSWF 210 220 230 240 250 260 270 280 290 300 GGSLDGFLLT PITMSFPFCN SREINHFFCE APAVLKLACA DTALYETVMY VCCVLMLLIP FSVVLASYAR ILTTVQCMSS VEGRKKAFAT CSSHMTVVSL 310 320 330 340 350 360 370 FYGAAMYTYM LPHSYHKPAQ DKVLSVFYTI LTPMLNPLIY SLRNKDVTGA LKRALGRFKG PQRVSGGVF
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 D Q A P Y L A T D T I S I T R L Y T E K R L V K S H P L T E Y P T L L G V F N V L L G S Y F V S M Y T V Y M V F G D Q A T C M K P V I A F I L I T Y M A A V C C L S G G L F H I T S I S I L M P T G Y F L L M L F W S L T L Y I Y M M T F F I L P N L S V V F P I G A I I A G V D I L M L A Y I T M H L V V S M W C L F F E S L H S V G N A S S C T Y S A V R R S L G L L L F F I M A F A L I R A D Y A M Y M P T T Q I L K K R G V T T V Y R D M C Q N C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| diallyl disulfide | -4.72 1 | 5 1 | alliaceous, garlic, metallic, onion | |
| dipropyl disulfide | -4.47 1 | - | sulfurous, earthy, burnt, onion, green_onion | |
| hydrogen sulfide | - | 6.9565 2 | egg, sulfurous | |
| butyric acid | -3.81 3 | 0.131 3 | sharp, acetic, cheesy, buttery, fruity, dairy, creamy | |
| methanethiol | - | 2.6087 2 | alliaceous, cabbage, cheesy, creamy, eggy, garlic, meaty, oily, vegetable | |
| allyl mercaptan | - | 0 1 | alliaceous, sulfurous, garlic, onion, roasted, cooked_onion, grilled, charred, meaty | |
| di-tert-butyl disulfide | - | 0 1 | garlic, green_onion, sulfurous | |
| diallyl sulfide | - | 0 1 | sulfurous, onion, garlic, horseradish, metallic, pungent | |
| methyl furfuryl disulfide | - | 0 1 | sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy |
1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025
2.) Antagonistic interactions between odorants alter human odor perception Yosuke Fukutani, Masashi Abe, Haruka Saito, Ryo Eguchi, Toshiaki Tazawa, Claire A. de March, Masafumi Yohda, Hiroaki Matsunami bioRxiv 2022.08.02.502184; doi: https://doi.org/10.1101/2022.08.02.502184
3.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR2T1 | 100 | 69% | Y | H | Y | L | V | G | F | F | G | D | G | L | F | E | A | P | M | C | C | M | L | Y | A | Y | H | S | V | Y | T |
| OR2T27 | 99 | 96% | Y | H | Y | L | A | G | F | F | G | D | G | L | F | E | V | P | M | C | C | M | L | Y | A | Y | H | S | A | Y | T |
| OR2T5 | 95 | 100% | Y | M | Y | L | A | G | F | F | G | D | G | L | F | E | V | P | M | C | C | M | L | Y | A | Y | S | S | V | Y | T |
| OR2T29 | 95 | 100% | Y | M | Y | L | A | G | F | F | G | D | G | L | F | E | V | P | M | C | C | M | L | Y | A | Y | S | S | V | Y | T |
| OR2T2 | 94 | Y | I | Y | L | I | G | F | F | G | D | G | L | F | E | I | P | M | C | C | M | L | Y | A | N | H | S | A | Y | T | |
| OR2T4 | 94 | 80% | Y | M | Y | V | A | G | F | F | G | D | G | F | F | E | V | P | M | C | C | M | L | Y | A | Y | S | S | V | Y | T |
| OR2T35 | 93 | Y | I | L | L | I | G | F | F | G | D | G | L | F | E | I | P | M | C | C | M | L | Y | A | N | H | S | A | Y | T | |
| OR2T11 | 92 | 96% | F | I | Y | L | I | G | F | F | G | D | G | L | F | E | I | P | M | C | C | M | L | Y | A | Y | Q | S | A | Y | T |
| OR2T6 | 89 | 92% | Y | C | Y | M | M | G | F | F | G | D | S | L | F | E | A | P | M | C | C | M | L | Y | A | Y | Q | S | A | Y | T |
| OR2T10 | 87 | 92% | Y | M | Y | L | G | G | C | C | G | D | G | L | F | E | V | P | M | C | C | M | L | Y | A | Y | S | S | F | Y | T |
| OR2T3 | 87 | Y | M | Y | L | A | G | V | F | G | D | G | L | F | E | T | P | M | C | C | M | L | F | S | Y | S | S | A | Y | T | |
| OR2M4 | 87 | 96% | L | I | Y | V | L | G | C | F | G | D | G | V | F | D | V | A | L | C | C | M | L | Y | A | Y | A | S | A | Y | T |
| OR11L1 | 86 | 100% | Y | L | F | V | G | A | C | F | G | T | G | P | F | D | L | P | I | L | S | V | L | Y | M | Y | S | S | V | Y | T |
| OR2M5 | 85 | 34% | L | I | Y | V | L | G | C | F | G | D | A | D | F | D | F | P | L | C | C | M | I | Y | G | Y | T | S | V | Y | T |
| OR2V2 | 85 | 96% | L | I | F | V | V | G | G | L | G | D | G | Q | F | E | M | L | I | C | C | M | L | Y | A | Y | R | S | I | Y | T |
| OR10AD1 | 84 | 100% | F | M | V | F | G | V | C | I | G | N | G | L | F | E | A | P | I | D | A | V | I | Y | A | Y | H | S | L | Y | T |
| OR2T12 | 83 | 69% | L | I | L | P | G | G | C | F | G | D | G | Q | F | E | A | P | M | C | C | M | L | Y | G | Y | K | S | A | Y | T |
| OR2M2 | 83 | 100% | L | I | Y | I | S | G | C | F | G | D | G | D | F | E | F | P | I | C | C | M | L | Y | A | Y | T | S | V | Y | T |
| OR2M3 | 82 | 100% | L | I | Y | T | L | G | C | F | G | D | G | D | F | D | F | P | L | C | C | M | I | Y | A | Y | T | S | V | Y | T |
| OR2T34 | 82 | Y | M | H | L | A | G | V | F | G | D | G | L | F | E | T | P | T | C | C | M | L | F | S | Y | S | S | A | Y | T | |
| OR2AG1 | 82 | 100% | F | M | A | L | G | G | D | L | A | S | A | Y | L | E | I | P | V | M | G | F | L | Y | A | Y | S | S | V | Y | T |
| OR2V1 | 82 | L | I | F | V | V | G | G | L | G | D | G | Q | F | E | V | Q | L | C | C | M | L | Y | A | Y | R | S | I | Y | T | |
| OR2AK2 | 81 | 96% | Y | T | F | L | G | G | A | L | G | N | A | H | F | E | V | P | V | S | G | I | L | Y | T | Y | H | A | V | Y | T |
| OR2M7 | 80 | 34% | L | I | Y | I | L | G | C | F | G | D | G | D | C | D | F | P | I | C | C | M | L | Y | G | C | T | S | V | Y | T |
| OR10K2 | 80 | 96% | Y | M | F | L | G | C | S | F | G | V | A | I | F | D | I | A | I | L | C | V | L | Y | A | Y | Q | S | V | Y | T |
| OR5J2 | 80 | 57% | Y | H | F | G | I | T | G | F | G | N | T | H | F | D | I | P | L | F | S | I | A | Y | L | Y | S | S | M | Y | T |