Olfactory Receptor family 2 subfamily M member 4.
Estimated Expression: 96% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MVWENQTFNS IFILLGIFNH SPTHTFLFSL VLGIFSLALM ENISMVLLIY IEKQLHTPMY FLLSQLSLMD LMLICTTLPK MIFSYLSGKK SISLAGCGTQ 110 120 130 140 150 160 170 180 190 200 IFFYVSLLGA ECFLLAVMAY DRYVAICHPL QYTILMNPKL CVFMTVASWT LGSLDGIIVL AAVLSFSYCS SLEIHHFFCD VAALLPLSCT ETSAFERLLV 210 220 230 240 250 260 270 280 290 300 ICCVVMLIFP VSVIILSYSH VLRAVIHMGS GESRRKAFTT CSSHLSVVGL YYGAAMFMYM RPASKHTPDQ DKMVSAFYTI LTPMLNPLIY SLRNKEVFRA 310 320 LQKVLKKRKL I
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 D Q D P K A S T E V A S I S K L Y T P S H V M K S A P R R E F A L V I G A L S F I F T H Y F A S M Y M I V L L I G D Q T G C M K P L L S F L L I T F M A A V C C L S G L F F I T T C G L V L M P T G Y Y I L M V T W S L S V Y I L M L L S F I L P N L G V V V P F A V T M A G L D M L M L A Y I S L H I I V S F V C L F C E S L Q S S I N E S S C T Y S L L K P N V A L L L F L V M T F A L V H S D Y A M Y M P T I Y I L K R R S V A R V Y R E M H I H C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| estragole | -5.7 1 | 9.5 1 | sweet, sassafrass, anise, spicy, green, herbal, fennel, phenolic, minty | |
| cresyl methyl ether | -4.8 1 | 10 1 | naphthyl, narcissus, ylang, powdery, nutty | |
| alpha-damascone | -4.8 1 | 4.7 1 | floral, rose, apple, fruity, black_currant, sweet, green, berry | |
| fructone | -4 1 | 5 1 | apple, fruity, green, plum, sweet, tropical, woody | |
| vanillin | -3.4 1 | 5.5 1 | chocolate, creamy, sweet, vanilla | |
| cinnamaldehyde | -4 1 | (agonist) 1 | sweet, spicy, candy, cinnamon, warm | |
| nerolidol | -4 1 | (agonist) 1 | floral, green, waxy, citrus, woody, fruity, melon |
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR2M4 | 100 | 96% | L | I | Y | V | L | G | C | F | G | D | G | V | F | D | V | A | L | C | C | M | L | Y | A | Y | A | S | A | Y | T |
| OR2M5 | 91 | 34% | L | I | Y | V | L | G | C | F | G | D | A | D | F | D | F | P | L | C | C | M | I | Y | G | Y | T | S | V | Y | T |
| OR2T11 | 90 | 96% | F | I | Y | L | I | G | F | F | G | D | G | L | F | E | I | P | M | C | C | M | L | Y | A | Y | Q | S | A | Y | T |
| OR2T5 | 90 | 100% | Y | M | Y | L | A | G | F | F | G | D | G | L | F | E | V | P | M | C | C | M | L | Y | A | Y | S | S | V | Y | T |
| OR2T12 | 90 | 69% | L | I | L | P | G | G | C | F | G | D | G | Q | F | E | A | P | M | C | C | M | L | Y | G | Y | K | S | A | Y | T |
| OR2T29 | 90 | 100% | Y | M | Y | L | A | G | F | F | G | D | G | L | F | E | V | P | M | C | C | M | L | Y | A | Y | S | S | V | Y | T |
| OR2T4 | 89 | 80% | Y | M | Y | V | A | G | F | F | G | D | G | F | F | E | V | P | M | C | C | M | L | Y | A | Y | S | S | V | Y | T |
| OR2T10 | 89 | 92% | Y | M | Y | L | G | G | C | C | G | D | G | L | F | E | V | P | M | C | C | M | L | Y | A | Y | S | S | F | Y | T |
| OR2T2 | 88 | Y | I | Y | L | I | G | F | F | G | D | G | L | F | E | I | P | M | C | C | M | L | Y | A | N | H | S | A | Y | T | |
| OR2V2 | 88 | 96% | L | I | F | V | V | G | G | L | G | D | G | Q | F | E | M | L | I | C | C | M | L | Y | A | Y | R | S | I | Y | T |
| OR11L1 | 88 | 100% | Y | L | F | V | G | A | C | F | G | T | G | P | F | D | L | P | I | L | S | V | L | Y | M | Y | S | S | V | Y | T |
| OR2M3 | 87 | 100% | L | I | Y | T | L | G | C | F | G | D | G | D | F | D | F | P | L | C | C | M | I | Y | A | Y | T | S | V | Y | T |
| OR2T35 | 87 | Y | I | L | L | I | G | F | F | G | D | G | L | F | E | I | P | M | C | C | M | L | Y | A | N | H | S | A | Y | T | |
| OR2M2 | 87 | 100% | L | I | Y | I | S | G | C | F | G | D | G | D | F | E | F | P | I | C | C | M | L | Y | A | Y | T | S | V | Y | T |
| OR2T8 | 87 | 96% | L | I | L | P | G | G | C | F | G | D | G | Q | F | E | T | P | M | C | C | M | L | Y | A | Y | K | S | A | Y | T |
| OR2T33 | 87 | 92% | L | I | L | P | G | G | C | F | G | D | G | Q | F | E | T | P | M | C | C | M | L | Y | A | Y | K | S | A | Y | T |
| OR2T27 | 87 | 96% | Y | H | Y | L | A | G | F | F | G | D | G | L | F | E | V | P | M | C | C | M | L | Y | A | Y | H | S | A | Y | T |
| OR2T1 | 87 | 69% | Y | H | Y | L | V | G | F | F | G | D | G | L | F | E | A | P | M | C | C | M | L | Y | A | Y | H | S | V | Y | T |
| OR10AD1 | 86 | 100% | F | M | V | F | G | V | C | I | G | N | G | L | F | E | A | P | I | D | A | V | I | Y | A | Y | H | S | L | Y | T |
| OR2V1 | 86 | L | I | F | V | V | G | G | L | G | D | G | Q | F | E | V | Q | L | C | C | M | L | Y | A | Y | R | S | I | Y | T | |
| OR2M7 | 85 | 34% | L | I | Y | I | L | G | C | F | G | D | G | D | C | D | F | P | I | C | C | M | L | Y | G | C | T | S | V | Y | T |
| OR2T6 | 85 | 92% | Y | C | Y | M | M | G | F | F | G | D | S | L | F | E | A | P | M | C | C | M | L | Y | A | Y | Q | S | A | Y | T |
| OR2T3 | 85 | Y | M | Y | L | A | G | V | F | G | D | G | L | F | E | T | P | M | C | C | M | L | F | S | Y | S | S | A | Y | T | |
| OR10K2 | 85 | 96% | Y | M | F | L | G | C | S | F | G | V | A | I | F | D | I | A | I | L | C | V | L | Y | A | Y | Q | S | V | Y | T |
| OR5V1 | 84 | 96% | Y | L | F | V | V | G | C | L | G | N | S | H | F | D | I | P | L | T | G | I | G | Y | A | Y | I | S | V | Y | S |
| OR8D4 | 84 | 96% | Y | L | F | C | V | I | C | Y | G | D | A | H | F | D | I | V | I | I | G | N | M | Y | L | Y | A | S | V | Y | T |
| OR2AG1 | 82 | 100% | F | M | A | L | G | G | D | L | A | S | A | Y | L | E | I | P | V | M | G | F | L | Y | A | Y | S | S | V | Y | T |
| OR2W3 | 82 | 100% | F | L | F | L | G | G | C | L | G | N | S | M | L | E | M | P | V | L | A | V | V | Y | I | Y | G | M | L | Y | N |
| OR2C1 | 81 | 100% | F | L | F | L | G | A | C | I | G | N | S | Q | L | E | V | P | L | V | C | F | T | Y | A | Y | A | S | L | Y | S |
| OR11G2 | 80 | 80% | Y | F | F | F | G | S | C | F | G | W | F | P | L | D | P | A | F | L | S | P | V | Y | V | Y | P | T | L | Y | S |
| OR2T34 | 80 | Y | M | H | L | A | G | V | F | G | D | G | L | F | E | T | P | T | C | C | M | L | F | S | Y | S | S | A | Y | T | |
| OR8J3 | 80 | 96% | N | L | F | L | I | V | V | M | G | T | A | V | Y | D | I | A | V | S | A | N | L | Y | M | Y | Q | S | V | Y | T |
| OR10R2 | 80 | 57% | Y | M | F | L | A | I | C | L | G | A | S | V | F | D | I | S | I | C | G | V | L | Y | A | Y | T | T | V | Y | T |
| OR10T2 | 80 | 65% | Y | L | F | L | A | C | C | L | G | I | A | A | F | D | M | A | L | L | S | V | I | Y | A | Y | K | A | V | Y | T |
| OR14C36 | 80 | 84% | Y | V | V | V | V | Y | L | L | G | Y | A | H | F | D | I | P | I | S | A | V | G | L | C | Y | P | S | G | Y | S |
| OR8B2 | 80 | 88% | Y | L | F | L | V | I | C | Y | G | G | A | H | L | D | I | L | V | V | V | N | I | F | A | Y | Y | S | V | Y | T |
| OR8B3 | 80 | 88% | Y | L | F | L | V | I | C | Y | G | G | A | H | L | D | I | L | V | V | V | N | I | F | A | Y | Y | S | V | Y | T |
| OR2Z1 | 80 | 84% | C | I | L | T | G | V | G | V | G | N | A | Q | F | E | V | P | L | S | G | I | L | Y | A | Y | C | S | L | Y | S |
| OR3A3 | 80 | 38% | C | L | F | H | A | G | C | F | A | N | A | H | Y | D | L | P | L | A | A | M | A | Y | G | Y | G | G | V | M | T |
| OR8D1 | 80 | 96% | Y | L | F | V | V | V | G | Y | G | S | A | H | F | D | V | L | L | I | A | N | T | F | I | Y | P | S | V | Y | T |