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Olfactory Receptor family 2 subfamily M member 3.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MARENSTFNS DFILLGIFNH SPTHTFLFFL VLAIFSVAFM GNSVMVLLIY LDTQLHTPMY LLLSQLSLMD LMLICTTVPK MAFNYLSGSK SISMAGCATQ 

       110        120        130        140        150        160        170        180        190        200 
IFFYTSLLGS ECFLLAVMAY DRYTAICHPL RYTNLMSPKI CGLMTAFSWI LGSTDGIIDV VATFSFSYCG SREIAHFFCD FPSLLILSCS DTSIFEKILF 

       210        220        230        240        250        260        270        280        290        300 
ICCIVMIVFP VAIIIASYAR VILAVIHMGS GEGRRKAFTT CSSHLLVVGM YYGAALFMYI RPTSDRSPTQ DKMVSVFYTI LTPMLNPLIY SLRNKEVTRA 

       310        320 
FMKILGKGKS GE

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

T P S H     F A   G A M S       A   I S T D     P R   Q T P S  
 F T H   M K P V   T A C   V V D I   K E F   I Y M F   M K D   
L F F L   T T C   F F I Q   I G D   I F L I   L A A   F V S V  
 A L V   I L M L   S T Y   T S G L   I C C   G Y Y M   I T Y   
V S F I   D M L   S G L L   I W S   V I M V   G V V   M P T L  
 M F A   S L Q S   F C E   F A T M   V P F   L L H S   P N L   
V S N G   L L L   V A L L   L G C   I I I A   S C T   S Y I L  
 L V M   Y M P T   Y A M   I K P S   Y S A   T F A K       L   
  Y I L           T Y R D           I V R A   R R G            
                   C I A             V A L   E G S G           
                        H               H I                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
3-mercapto-2-methylpentan-1-ol -7.54 1 10 1  onion, brothy, sweaty, leek
2-methylisoborneol -4.4 2 1.1176 2  earthy, musty
3-mercapto-2-methylhexan-1-ol -2.5 3 1.5 3  onion
3-mercapto-2-methylbutan-1-ol -2.4 3 1 3  brothy, onion, sulfurous
allyl methyl sulfide - 0 3  alliaceous, garlic, onion, sulfurous, savory
diallyl disulfide - 0 3  alliaceous, garlic, metallic, onion
dimethyl disulfide - 0 3  sulfurous, vegetable, cabbage, onion, malty, creamy
dimethyl trisulfide - 0 3  sulfurous, onion, cooked, savory, meaty
dipropyl disulfide - 0 3  sulfurous, earthy, burnt, onion, green_onion
dipropyl trisulfide - 0 3  sulfurous, alliaceous, onion, green, garlic, tropical
ethyl methyl mercaptopropionate - 0 3  sulfurous, metallic, pineapple, fruity, ripe, pulpy, tomato
fish thiol - 0 3  sulfurous, meaty, fishy, metallic
2-furfurylthiol - 0 3  coffee, sulfurous, burnt
grapefruit mercaptan - 0 3  sulfurous, aromatic, grapefruit, naphthyl, resinous, woody, alliaceous, onion, garlic, tropical
3-mercapto-2-pentanone - 0 3  sulfurous, metallic, roasted, onion, horseradish, potato
3-mercapto-3-methyl-1-butyl acetate - 0 3  fruity, sulfurous, sweet
2-mercapto-3-pentanone - 0 3  roasted, meaty
2-mercaptohexanol - 0 3  
3-mercaptohexyl acetate - 0 3  floral, fruity, pear, tropical, passionfruit, blackberry, raspberry, blackcurrant_bud
methional - 0 3  vegetable, oily, creamy, tomato, potato, yeasty, bready, cheesy, limburger, cheese, savory, meaty, brothy
methionol - 0 3  sulfurous, onion, sweet, soup, vegetable
methyl 2-methyl-3-furyl disulfide - 0 3  sulfurous, meaty, vegetable, onion, beefy, roasted
4-methyl 4-mercaptopentan-2-one - 0 3  sulfurous, meaty, catty, currant, bud, black, green, fruity
methyl propyl trisulfide - 0 3  sulfurous, onion, garlic, green, metallic
3-methyl-3-mercapto butyl methyl ether - 0 3  
2-phenylethanethiol - 0 3  rubbery, sulfurous
2-thiophene thiol - 0 3  burnt, caramellic, roasted, coffee
truffle sulfide - 0 3  garlic, sulfurous, green, spicy, mushroom

1.) Haag, Franziska et al. “Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3.” Cellular and molecular life sciences : CMLS vol. 77,11 (2020): 2157-2179. doi:10.1007/s00018-019-03279-y

2.) Aya Kato, Naoko Saito (2017) Search method for mold odor inhibitor JP6104058B2

3.) Franziska Noe, Johannes Polster, Christiane Geithe, Matthias Kotthoff, Peter Schieberle, and Dietmar Krautwurst OR2M3: A Highly Specific and Narrowly Tuned Human Odorant Receptor for the Sensitive Detection of Onion Key Food Odorant 3-Mercapto-2-methylpentan-1-ol Chemical Senses, 2017, Vol 42, 195–210 doi:10.1093/chemse/bjw118

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