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Olfactory Receptor family 2 subfamily M member 3.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MARENSTFNS DFILLGIFNH SPTHTFLFFL VLAIFSVAFM GNSVMVLLIY LDTQLHTPMY LLLSQLSLMD LMLICTTVPK MAFNYLSGSK SISMAGCATQ 

       110        120        130        140        150        160        170        180        190        200 
IFFYTSLLGS ECFLLAVMAY DRYTAICHPL RYTNLMSPKI CGLMTAFSWI LGSTDGIIDV VATFSFSYCG SREIAHFFCD FPSLLILSCS DTSIFEKILF 

       210        220        230        240        250        260        270        280        290        300 
ICCIVMIVFP VAIIIASYAR VILAVIHMGS GEGRRKAFTT CSSHLLVVGM YYGAALFMYI RPTSDRSPTQ DKMVSVFYTI LTPMLNPLIY SLRNKEVTRA 

       310        320 
FMKILGKGKS GE

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


D Q T P       D   I S T D     T A   S I S K      L Y  T P S H  
 V M K   S T P R   K E F   V V D I   G A M    N F A    F T H   
Y F V S   I Y M   I F L I   I G D   Q T A C  M K P V  L F F L  
 L I T   F L A A   I C C   T S G L   F F I    T T C    A L V   
L M P T   G Y Y   V I M V   I W S   L S T Y  I L M L  V S F I  
 L P N   M G V V   V P F   F A T M   S G L    D M L    M F A   
    Y I   L L H   I I I A   L G C   L F C E  S L Q S  V S N G  
         S S C T   Y S A   I K P S   V A L    L L L    L V M   
          T F A   I V R A           D Y A M  Y M P T  L Y I L  
         K R R G   V A L             T Y R                 D   
                    M H I           H C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
3-mercapto-2-methylpentan-1-ol -7.54 1 10 1  onion, brothy, sweaty, leek
2-methylisoborneol -4.4 2 1.1176 2  earthy, musty
3-mercapto-2-methylbutan-1-ol -3.97 1 1 1  brothy, onion, sulfurous
3-mercapto-2-methylhexan-1-ol -2.5 3 1.5 3  onion
allyl methyl sulfide - 0 3  alliaceous, garlic, onion, sulfurous, savory
diallyl disulfide - 0 3  alliaceous, garlic, metallic, onion
dimethyl disulfide - 0 3  sulfurous, vegetable, cabbage, onion, malty, creamy
dimethyl trisulfide - 0 3  sulfurous, onion, cooked, savory, meaty
dipropyl disulfide - 0 3  sulfurous, earthy, burnt, onion, green_onion
dipropyl trisulfide - 0 3  sulfurous, alliaceous, onion, green, garlic, tropical
ethyl methyl mercaptopropionate - 0 3  sulfurous, metallic, pineapple, fruity, ripe, pulpy, tomato
fish thiol - 0 3  sulfurous, meaty, fishy, metallic
2-furfurylthiol - 0 3  coffee, sulfurous, burnt
grapefruit mercaptan - 0 3  sulfurous, aromatic, grapefruit, naphthyl, resinous, woody, alliaceous, onion, garlic, tropical
3-mercapto-1-hexanol - 0 1  sulfurous, savory, chicken, meaty, roasted, coffee, fruity
3-mercapto-2-pentanone - 0 3  sulfurous, metallic, roasted, onion, horseradish, potato
3-mercapto-3-methyl-1-butyl acetate - 0 3  fruity, sulfurous, sweet
2-mercapto-3-pentanone - 0 3  roasted, meaty
2-mercaptohexanol - 0 3  
3-mercaptohexyl acetate - 0 3  floral, fruity, pear, tropical, passionfruit, blackberry, raspberry, blackcurrant_bud
methional - 0 3  vegetable, oily, creamy, tomato, potato, yeasty, bready, cheesy, limburger, cheese, savory, meaty, brothy
methionol - 0 3  sulfurous, onion, sweet, soup, vegetable
methyl 2-methyl-3-furyl disulfide - 0 3  sulfurous, meaty, vegetable, onion, beefy, roasted
4-methyl 4-mercaptopentan-2-one - 0 3  sulfurous, meaty, catty, currant, bud, black, green, fruity
methyl propyl trisulfide - 0 3  sulfurous, onion, garlic, green, metallic
3-methyl-3-mercapto butyl methyl ether - 0 3  catty, blackcurrant
nootkatone - 0 1  grapefruit_peel, citrus, gardenia, woody, grapefruit, orange, sweet, peely, bitter
paradisamide - 0 1  bitter, tropical, grapefruit, rhubarb, guava
phenethyl mercaptan - 0 3  rubbery, sulfurous
2-thiophene thiol - 0 3  burnt, caramellic, roasted, coffee
truffle sulfide - 0 3  garlic, sulfurous, green, spicy, mushroom
hexanal -3.9 4 -0.5 4 Y 4aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty

1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

2.) Aya Kato, Naoko Saito (2017) Search method for mold odor inhibitor JP6104058B2

3.) Franziska Noe, Johannes Polster, Christiane Geithe, Matthias Kotthoff, Peter Schieberle, and Dietmar Krautwurst OR2M3: A Highly Specific and Narrowly Tuned Human Odorant Receptor for the Sensitive Detection of Onion Key Food Odorant 3-Mercapto-2-methylpentan-1-ol Chemical Senses, 2017, Vol 42, 195–210 doi:10.1093/chemse/bjw118

4.) Ojiro I, Katsuyama H, Kaneko R, Ogasawara S, Murata T, Terada Y, et al. (2024) Enhancement of transcription efficiency by TAR-Tat system increases the functional expression of human olfactory receptors. PLoS ONE 19(6): e0306029. https://doi.org/10.1371/journal.pone.0306029
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR2M3100 100%L I Y T L G C F G D G D F D F P L C C M I Y A Y T S V Y T
OR2M596 34%L I Y V L G C F G D A D F D F P L C C M I Y G Y T S V Y T
OR2M292 100%L I Y I S G C F G D G D F E F P I C C M L Y A Y T S V Y T
OR2T1291 69%L I L P G G C F G D G Q F E A P M C C M L Y G Y K S A Y T
OR2M790 34%L I Y I L G C F G D G D C D F P I C C M L Y G C T S V Y T
OR2T889 96%L I L P G G C F G D G Q F E T P M C C M L Y A Y K S A Y T
OR2T3389 92%L I L P G G C F G D G Q F E T P M C C M L Y A Y K S A Y T
OR2V289 96%L I F V V G G L G D G Q F E M L I C C M L Y A Y R S I Y T
OR2M487 96%L I Y V L G C F G D G V F D V A L C C M L Y A Y A S A Y T
OR2V186L I F V V G G L G D G Q F E V Q L C C M L Y A Y R S I Y T
OR2T486 80%Y M Y V A G F F G D G F F E V P M C C M L Y A Y S S V Y T
OR2T586 100%Y M Y L A G F F G D G L F E V P M C C M L Y A Y S S V Y T
OR2T2986 100%Y M Y L A G F F G D G L F E V P M C C M L Y A Y S S V Y T
OR2T1186 96%F I Y L I G F F G D G L F E I P M C C M L Y A Y Q S A Y T
OR2Z185 84%C I L T G V G V G N A Q F E V P L S G I L Y A Y C S L Y S
OR2T1085 92%Y M Y L G G C C G D G L F E V P M C C M L Y A Y S S F Y T
OR9I185 96%Y F F T A G C F G G A R F D L P I F G V I F L Y S S V Y T
OR11L185 100%Y L F V G A C F G T G P F D L P I L S V L Y M Y S S V Y T
OR9Q184 96%Y F F T G S C Y G S A R F D L P I F A V I F L Y N S V Y T
OR9Q284 100%Y F F T A S C Y G S A R F D L P I F A V M F L Y N S V Y T
OR2T381Y M Y L A G V F G D G L F E T P M C C M L F S Y S S A Y T
OR2AG181 100%F M A L G G D L A S A Y L E I P V M G F L Y A Y S S V Y T
OR2T281Y I Y L I G F F G D G L F E I P M C C M L Y A N H S A Y T
OR10A281F M F F G V C F G V A Q F D S P A G T V V Y L Y K S L Y T
OR2T681 92%Y C Y M M G F F G D S L F E A P M C C M L Y A Y Q S A Y T
OR10A381 100%F M I L G G C F G V A Q F E T P A G T I V Y A Y K S L Y T
OR2T3580Y I L L I G F F G D G L F E I P M C C M L Y A N H S A Y T
OR10K280 96%Y M F L G C S F G V A I F D I A I L C V L Y A Y Q S V Y T
OR8D480 96%Y L F C V I C Y G D A H F D I V I I G N M Y L Y A S V Y T
OR10AD180 100%F M V F G V C I G N G L F E A P I D A V I Y A Y H S L Y T
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