OR4F21

Olfactory Receptor family 4 subfamily F member 21.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MDGENHSVVS EFLFLGLTHS WEIQLLLLVF SSVLYVASIT GNIFIVFSVT TDPHLHSPMY FLLASLSFID LGACSVTSPK MIYDLFRKRK VISFGGCIAQ 

       110        120        130        140        150        160        170        180        190        200 
IFFIHVIGGV EMVLLIAMAF DRYVALCKPL HYLTIMSPRM CLSFLAVAWT LGVSHSLFQL AFLVNLAFCG PNVLDSFYCD LPRLLRLACT DTYRLQFMVT 

       210        220        230        240        250        260        270        280        290        300 
VNSGFICVGT FFILLISYVF ILFTVWKHSS GGSSKALSTL SAHSTVVLLF FGPPMFVYTR PHPNSQMDKF LAIFDAVLTP FLNPVVYTFR NKEMKAAIKR 

       310        320 
VCKQLVIYKK IS

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


L F K D       N   R Y T D     L F   S I V K      F L  I E W S  
 F I A   P H P R   F Q L   A L Q F   G G F    D Y I    L L Q   
L V A D   T Y V   V T V M   L S H   Q A I C  M K P S  F V L L  
 F P T   F M P P   G S N   S V G L   F F I    T V S    V S S   
V P N L   G F F   V C I F   T W A   I V H I  C A G L  A V Y L  
 T Y V   L L V V   F T G   V A L F   V G G    D I F    T I S   
          T S H   L L I F   S L C   L V M E  S L S A  F I N G  
         A S L T   Y S I   M R P S   A I L    L L F    F V I   
          S L A   L I F V           D F A M  Y M P S  T T V S  
         K S S G   V T F             V Y R                 D   
                      K W           K C L A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards

Odorant	EC₅₀	Adjusted Top	Antagonist?	Aroma Notes
butyric acid	-4.69 ¹	0.4808 ¹		sharp, acetic, cheesy, buttery, fruity, dairy, creamy
butyl acetate	-2.74 ¹	0.1227 ¹		ethereal, solvent, fruity, banana

1.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

Prot.	Sim.	Expr.	2.53	3.29	3.32	3.33	3.36	3.37	3.40	3.41	4.53	4.56	4.57	4.60	45.49	45.51	45.52	45.53	5.39	5.42	5.43	5.46	5.47	6.48	6.51	6.55	6.59	7.38	7.39	7.41	7.42
OR4F21	100	100%	A	I	I	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	I	C	F	P	Y	P	A	I	D	A
OR4F3	100	100%	A	I	I	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	I	C	F	P	Y	P	A	I	D	A
OR4F6	96		F	I	I	H	G	G	M	V	G	H	S	Q	F	D	L	P	V	N	S	I	S	F	L	Y	P	A	I	D	A
OR4F15	93	92%	F	I	S	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	I	S	F	L	Y	P	A	I	D	A
OR4C3	90	34%	Y	L	A	H	G	G	I	I	G	H	S	Q	A	D	L	Y	V	N	S	I	C	F	C	Y	P	A	L	Y	G
OR4F4	88	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4F5	88	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4F17	88	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4K17	88	84%	L	I	L	H	G	G	M	V	G	H	S	Q	F	D	L	P	I	N	S	I	S	F	C	Y	P	A	V	Y	T
OR4C15	87	69%	F	L	E	H	A	G	V	I	G	H	S	Q	M	D	L	Y	V	N	S	I	C	F	C	Y	P	A	I	Y	I
OR4S1	86	42%	Y	L	A	H	G	G	I	F	G	H	S	Q	F	D	V	H	V	N	S	I	S	L	P	Y	S	I	L	N	I
OR4B1	85	69%	Y	I	F	H	G	V	I	L	G	H	S	Q	F	D	L	Q	V	N	S	F	S	F	A	Y	P	A	V	Y	T
OR4N2	84	73%	Y	L	L	H	G	G	G	L	G	H	S	Q	F	D	V	P	M	N	S	M	T	F	G	Y	P	S	L	H	T
OR4P4	84	57%	Y	L	T	H	G	G	I	F	G	H	S	Q	F	D	V	Y	V	N	S	I	A	F	A	Y	V	A	L	Y	T
OR4K14	84	80%	L	I	L	H	G	G	M	V	G	H	S	Q	F	D	L	P	M	D	S	L	S	F	C	Y	P	S	V	Y	T
OR4L1	84	11%	L	M	M	H	G	G	M	T	G	H	S	Q	F	D	L	P	V	D	S	L	S	F	C	Y	P	A	V	Y	T
OR4K13	84	96%	L	M	M	H	G	G	M	M	G	H	S	Q	F	D	L	P	V	D	S	L	S	F	C	Y	P	S	V	Y	T
OR4K15	84	42%	V	I	V	H	T	G	M	V	G	H	T	Q	F	D	L	P	I	D	S	L	S	F	C	Y	P	A	V	Y	T
OR4Q3	83	92%	L	I	L	H	G	A	M	F	G	H	S	Q	Y	D	V	P	V	N	S	L	S	F	C	Y	F	S	L	Y	T
OR4N5	82	96%	Y	L	L	H	G	A	M	F	G	H	S	Q	F	D	V	P	M	N	S	L	S	F	A	Y	F	S	L	H	T
OR4D1	82	100%	Y	I	F	H	G	G	V	F	G	H	S	Q	Y	D	V	P	M	N	S	L	V	F	C	Y	P	S	I	Y	T
OR4C6	82	69%	F	L	E	H	G	G	I	I	G	H	A	Q	I	D	L	F	V	N	S	M	C	F	C	Y	P	A	V	D	S
OR10G8	82	57%	F	L	F	H	G	G	C	F	G	H	S	Q	L	D	A	P	I	T	V	V	A	F	G	Y	G	A	V	Y	T
OR4Q2	81		Y	L	L	H	G	A	M	F	G	H	S	Q	F	D	V	P	M	N	S	I	S	F	C	Y	F	S	V	Y	N
OR4D5	81	80%	Y	L	F	H	G	G	I	F	G	H	S	Q	Y	D	V	P	M	N	N	V	T	F	C	Y	P	S	V	Y	T
OR4N4	81	34%	Y	L	L	H	G	G	G	L	G	H	S	Q	F	D	V	R	M	N	S	M	T	F	A	Y	P	S	L	H	T
OR4D6	81	65%	F	I	F	H	G	G	I	F	G	H	S	Q	Y	Y	V	L	M	N	N	V	T	F	C	Y	P	S	I	N	T
OR4K2	81	100%	L	I	L	H	T	G	I	I	G	H	S	Q	F	D	L	P	M	T	S	I	A	F	C	Y	P	S	V	Y	T
OR4K3	81		L	M	L	H	G	G	I	V	G	H	A	Q	F	D	L	P	M	T	S	I	A	F	C	Y	P	S	V	Y	T
OR4D11	80	34%	F	I	F	H	G	G	I	F	G	H	S	Q	Y	D	V	P	M	N	N	V	T	F	C	Y	P	S	V	F	T

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Inactive model:	text	3D	download
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