Olfactory Receptor family 4 subfamily D member 1.
Estimated Expression: 100% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MEPQNTTQVS MFVLLGFSQT QELQKFLFLL FLLVYVTTIV GNLLIMVTVT FDCRLHTPMY FLLRNLALID LCYSTVTSPK MLVDFLHETK TISYQGCMAQ 110 120 130 140 150 160 170 180 190 200 IFFFHLLGGG TVFFLSVMAY DRYIAISQPL RYVTIMNTQL CVGLVVAAWV GGFVHSIVQL ALILPLPFCG PNILDNFYCD VPQVLRLACT DTSLLEFLMI 210 220 230 240 250 260 270 280 290 300 SNSGLLVIIW FLLLLISYTV ILVMLRSHSG KARRKAASTC TTHIIVVSMI FIPCIYIYTW PFTPFLMDKA VSISYTVMTP MLNPMIYTLR NQDMKAAMRR 310 LGKCLVICRE
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 A K D M T L S T D I L I T K T L F L E Q T I S V F P W T F E L A L Q V Q Y S D V L F K Q V T Y S Y I Y S I M L I S H A M C G M K P S L L F L P T M I C P I G S N V F G G F I Q T V T L L F P N L M F I M I V L L V W A L H F F S Y C L T V Y V Y I M S V V I F W I A V V L G G L D I L V I T I H T L L L L G V C F V T G A L N R L L N G T C T S Y S I L Q T N S L F L L F V M I A A K L I V T Y A M V Y M P T F T V T R R A K L M V Y R D D S R S I A I UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Docks | Aroma Notes |
|---|---|---|---|---|---|
| androstenone | - | 10 1 | animal, musky | ||
| pi-23472 | - | 10 2 | |||
| furaneol | - | 0 1 | sweet, cotton_candy, caramellic, strawberry, brown_sugar | ||
| alpha-ionone | - | 0 1 | sweet, woody, floral, violet, orris, tropical, fruity | ||
| beta-ionone | - | 0 1 | beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent | ||
| 1-octen-3-one | - | 0 1 | earthy, metallic, mushroom |
1.) Hartmann C, Triller A, Spehr M, Dittrich R, Hatt H, Buettner A. Sperm-Activating Odorous Substances in Human Follicular Fluid and Vaginal Secretion: Identification by Gas Chromatography–Olfactometry and Ca2 Imaging. Chempluschem 78: 695–702, 2013. doi:10.1002/cplu.201300008
2.) Veitinger T, Riffell JR, Veitinger S, Nascimento JM, Triller A, Chandsawangbhuwana C, Schwane K, Geerts A, Wunder F, Berns MW, Neuhaus EM, Zimmer RK, Spehr M, Hatt H. Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm. J Biol Chem. 2011 May 13;286(19):17311-25. doi: 10.1074/jbc.M110.211524. Epub 2011 Mar 21. PMID: 21454470; PMCID: PMC3089573.