Olfactory Receptor family 4 subfamily D member 1.
Estimated Expression: 100% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MEPQNTTQVS MFVLLGFSQT QELQKFLFLL FLLVYVTTIV GNLLIMVTVT FDCRLHTPMY FLLRNLALID LCYSTVTSPK MLVDFLHETK TISYQGCMAQ 110 120 130 140 150 160 170 180 190 200 IFFFHLLGGG TVFFLSVMAY DRYIAISQPL RYVTIMNTQL CVGLVVAAWV GGFVHSIVQL ALILPLPFCG PNILDNFYCD VPQVLRLACT DTSLLEFLMI 210 220 230 240 250 260 270 280 290 300 SNSGLLVIIW FLLLLISYTV ILVMLRSHSG KARRKAASTC TTHIIVVSMI FIPCIYIYTW PFTPFLMDKA VSISYTVMTP MLNPMIYTLR NQDMKAAMRR 310 LGKCLVICRE
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 V A K D P L S T D I L S I T K L F L E Q T S I S T F P W F E L A L Q V G Q Y D V L F K Q M V T Y T Y I S I M L I S H Q A M C M K P S L L F L M P T Y I C P G S N V F G G F F I T V T L L F M P N L I F I I V L L V W A L L H F S Y C L T V Y V T Y I M S V V F W I A V V L G G G D I L V I T I I H L L L L G V C F F V T A L N R L L N G T T C T Y S I L Q T N V S L L L F V M I S A A L I V T D Y A M Y M P T F T V T K R R A L M V I Y R D S R Q S I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| pi-23472 | - | 10 1 | ||
| androstenone | - | 10 2 | animal, musky | |
| furaneol | - | 0 2 | sweet, cotton_candy, caramellic, strawberry, brown_sugar | |
| alpha-ionone | - | 0 2 | sweet, woody, floral, violet, orris, tropical, fruity | |
| beta-ionone | - | 0 2 | beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent | |
| 1-octen-3-one | - | 0 2 | earthy, metallic, mushroom |
1.) Veitinger T, Riffell JR, Veitinger S, Nascimento JM, Triller A, Chandsawangbhuwana C, Schwane K, Geerts A, Wunder F, Berns MW, Neuhaus EM, Zimmer RK, Spehr M, Hatt H. Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm. J Biol Chem. 2011 May 13;286(19):17311-25. doi: 10.1074/jbc.M110.211524. Epub 2011 Mar 21. PMID: 21454470; PMCID: PMC3089573.
2.) Hartmann C, Triller A, Spehr M, Dittrich R, Hatt H, Buettner A. Sperm-Activating Odorous Substances in Human Follicular Fluid and Vaginal Secretion: Identification by Gas Chromatography–Olfactometry and Ca2 Imaging. Chempluschem 78: 695–702, 2013. doi:10.1002/cplu.201300008
| 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR4D1 | Y | I | F | H | G | G | V | F | G | H | S | Q | Y | D | V | P | M | N | S | L | V | F | C | Y | P | S | I | Y | T |
| OR4D5 | Y | L | F | H | G | G | I | F | G | H | S | Q | Y | D | V | P | M | N | N | V | T | F | C | Y | P | S | V | Y | T |
| OR4D9 | F | M | F | H | G | G | V | F | G | H | S | Q | Y | D | V | P | M | N | N | V | S | F | C | Y | P | S | V | F | T |
| OR4D11 | F | I | F | H | G | G | I | F | G | H | S | Q | Y | D | V | P | M | N | N | V | T | F | C | Y | P | S | V | F | T |
| OR4Q2 | Y | L | L | H | G | A | M | F | G | H | S | Q | F | D | V | P | M | N | S | I | S | F | C | Y | F | S | V | Y | N |
| OR4Q3 | L | I | L | H | G | A | M | F | G | H | S | Q | Y | D | V | P | V | N | S | L | S | F | C | Y | F | S | L | Y | T |
| OR4K2 | L | I | L | H | T | G | I | I | G | H | S | Q | F | D | L | P | M | T | S | I | A | F | C | Y | P | S | V | Y | T |
| OR4K14 | L | I | L | H | G | G | M | V | G | H | S | Q | F | D | L | P | M | D | S | L | S | F | C | Y | P | S | V | Y | T |
| OR4D6 | F | I | F | H | G | G | I | F | G | H | S | Q | Y | Y | V | L | M | N | N | V | T | F | C | Y | P | S | I | N | T |
| OR4D10 | F | M | F | H | G | G | V | F | G | H | S | Q | Y | D | V | H | M | N | N | L | T | F | C | Y | P | S | V | F | T |
| OR4K3 | L | M | L | H | G | G | I | V | G | H | A | Q | F | D | L | P | M | T | S | I | A | F | C | Y | P | S | V | Y | T |
| OR4K13 | L | M | M | H | G | G | M | M | G | H | S | Q | F | D | L | P | V | D | S | L | S | F | C | Y | P | S | V | Y | T |
| OR4E2 | H | L | L | H | A | C | I | F | G | H | S | Q | F | D | V | P | I | N | S | I | S | F | C | Y | P | S | V | Y | T |
| OR4N2 | Y | L | L | H | G | G | G | L | G | H | S | Q | F | D | V | P | M | N | S | M | T | F | G | Y | P | S | L | H | T |
| OR4N5 | Y | L | L | H | G | A | M | F | G | H | S | Q | F | D | V | P | M | N | S | L | S | F | A | Y | F | S | L | H | T |
| OR4D2 | F | I | F | H | G | G | V | F | G | H | S | Q | Y | D | V | P | K | N | S | L | D | F | S | Y | P | S | I | H | T |
| OR4F4 | L | I | L | H | G | G | M | V | G | H | S | Q | Y | D | L | P | V | N | S | L | T | F | C | Y | P | A | V | Y | S |
| OR4F5 | L | I | L | H | G | G | M | V | G | H | S | Q | Y | D | L | P | V | N | S | L | T | F | C | Y | P | A | V | Y | S |
| OR4F17 | L | I | L | H | G | G | M | V | G | H | S | Q | Y | D | L | P | V | N | S | L | T | F | C | Y | P | A | V | Y | S |
| OR4A47 | Y | L | E | H | G | G | V | F | G | H | S | Q | F | D | M | Y | V | N | G | A | C | F | C | Y | P | S | V | Y | T |
| OR4K17 | L | I | L | H | G | G | M | V | G | H | S | Q | F | D | L | P | I | N | S | I | S | F | C | Y | P | A | V | Y | T |
| OR4A5 | Y | L | D | H | G | G | V | F | G | H | S | Q | S | D | M | H | V | N | S | I | C | F | C | Y | P | T | V | Y | T |
| OR4P4 | Y | L | T | H | G | G | I | F | G | H | S | Q | F | D | V | Y | V | N | S | I | A | F | A | Y | V | A | L | Y | T |
| OR4A16 | Y | L | E | H | G | G | V | F | G | H | S | Q | V | D | M | Y | V | N | G | I | C | F | C | Y | P | T | V | Y | S |
| OR4M1 | Y | L | L | H | G | A | M | F | G | H | S | Q | F | D | I | T | M | S | S | I | S | F | S | Y | P | S | V | H | T |
| OR4N4 | Y | L | L | H | G | G | G | L | G | H | S | Q | F | D | V | R | M | N | S | M | T | F | A | Y | P | S | L | H | T |
| OR4M2 | Y | L | L | H | G | A | M | F | G | H | S | Q | F | D | I | T | M | S | S | I | S | F | S | Y | P | S | V | N | T |
| OR10G8 | F | L | F | H | G | G | C | F | G | H | S | Q | L | D | A | P | I | T | V | V | A | F | G | Y | G | A | V | Y | T |
| OR4A15 | Y | L | D | H | A | G | V | I | G | H | S | Q | L | D | L | Y | M | N | G | I | C | F | C | Y | P | T | V | L | T |
| OR4C3 | Y | L | A | H | G | G | I | I | G | H | S | Q | A | D | L | Y | V | N | S | I | C | F | C | Y | P | A | L | Y | G |
| OR4L1 | L | M | M | H | G | G | M | T | G | H | S | Q | F | D | L | P | V | D | S | L | S | F | C | Y | P | A | V | Y | T |
| OR4S2 | Y | L | V | H | G | C | I | F | G | H | S | Q | F | D | V | H | V | N | S | I | A | F | C | Y | D | A | V | Y | T |
| OR4C5 | S | L | E | H | G | G | I | I | G | H | A | Q | I | D | L | F | V | N | S | M | C | F | C | Y | P | S | V | Y | T |
| OR10G4 | F | L | F | H | G | S | C | F | G | H | S | Q | F | D | A | P | I | D | I | V | A | F | C | Y | G | A | I | Y | T |
| OR4K1 | Q | I | L | H | V | G | M | M | G | H | S | H | F | D | L | P | T | N | S | I | S | F | C | Y | P | S | V | Y | T |
| OR4K15 | V | I | V | H | T | G | M | V | G | H | T | Q | F | D | L | P | I | D | S | L | S | F | C | Y | P | A | V | Y | T |
| OR4B1 | Y | I | F | H | G | V | I | L | G | H | S | Q | F | D | L | Q | V | N | S | F | S | F | A | Y | P | A | V | Y | T |
| OR10G9 | F | L | F | H | G | S | C | F | G | H | S | Q | L | D | A | P | I | D | I | V | A | F | C | Y | G | A | I | Y | T |
| OR10G7 | F | L | F | H | G | S | C | F | G | H | S | Q | F | D | A | P | I | N | I | V | A | F | G | Y | G | A | V | Y | T |
| OR4C15 | F | L | E | H | A | G | V | I | G | H | S | Q | M | D | L | Y | V | N | S | I | C | F | C | Y | P | A | I | Y | I |
| OR4F6 | F | I | I | H | G | G | M | V | G | H | S | Q | F | D | L | P | V | N | S | I | S | F | L | Y | P | A | I | D | A |
| OR4F3 | A | I | I | H | G | G | M | V | G | H | S | Q | Y | D | L | P | V | N | S | I | C | F | P | Y | P | A | I | D | A |
| OR4F21 | A | I | I | H | G | G | M | V | G | H | S | Q | Y | D | L | P | V | N | S | I | C | F | P | Y | P | A | I | D | A |
| OR4C11 | F | V | L | H | G | C | I | F | S | H | S | Q | C | D | L | Q | L | N | S | I | C | F | C | Y | P | A | V | Y | T |
| OR4X2 | Y | L | L | H | G | G | I | F | G | H | S | Q | F | D | L | V | I | N | G | L | S | F | C | S | S | A | V | Y | T |
| OR4C46 | Y | V | E | H | G | G | G | I | G | H | A | Q | M | D | L | N | I | N | S | I | C | F | C | Y | P | A | I | Y | T |
| OR4C6 | F | L | E | H | G | G | I | I | G | H | A | Q | I | D | L | F | V | N | S | M | C | F | C | Y | P | A | V | D | S |
| OR4K5 | Q | I | I | H | T | G | M | V | S | H | T | Q | F | D | L | P | I | N | S | L | S | F | C | Y | P | A | I | Y | T |
| OR10A7 | F | M | F | F | G | S | C | F | G | V | S | Q | F | D | G | P | A | S | T | F | I | Y | A | Y | K | S | L | Y | T |
| OR4F15 | F | I | S | H | G | G | M | V | G | H | S | Q | Y | D | L | P | V | N | S | I | S | F | L | Y | P | A | I | D | A |
| OR4X1 | Y | M | L | H | G | G | A | F | G | H | S | Q | F | D | V | H | I | N | G | I | S | F | C | Y | C | A | V | Y | T |
| OR4C13 | Y | V | E | H | R | G | V | I | G | H | A | Q | M | D | L | Y | I | N | S | I | C | F | C | Y | P | A | V | Y | T |
| OR2G2 | F | L | S | H | G | S | C | V | G | T | T | Q | I | E | V | P | L | A | S | F | L | Y | I | Y | A | S | L | Y | T |
| OR4A4 | Y | L | E | H | G | G | V | F | G | Q | S | Q | F | D | M | Y | V | N | G | S | C | F | C | C | A | S | V | Y | T |
| OR2G6 | F | L | A | M | G | S | C | I | G | T | S | Q | F | E | V | P | L | A | S | F | L | Y | I | Y | A | S | L | Y | T |
| OR4C12 | Y | A | E | H | G | A | I | I | G | H | A | Q | M | D | L | Y | V | N | S | I | C | F | C | Y | S | A | V | Y | T |