Olfactory Receptor family 51 subfamily A member 7.
Estimated Expression: 84% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MSVLNNSEVK LFLLIGIPGL EHAHIWFSIP ICLMYLLAIM GNCTILFIIK TEPSLHEPMY YFLAMLAVSD MGLSLSSLPT MLRVFLFNAM GISPNACFAQ 110 120 130 140 150 160 170 180 190 200 EFFIHGFTVM ESSVLLIMSL DRFLAIHNPL RYSSILTSNR VAKMGLILAI RSILLVIPFP FTLRRLKYCQ KNLLSHSYCL HQDTMKLACS DNKTNVIYGF 210 220 230 240 250 260 270 280 290 300 FIALCTMLDL ALIVLSYVLI LKTILSIASL AERLKALNTC VSHICAVLTF YVPIITLAAM HHFAKHKSPL VVILIADMFL LVPPLMNPIV YCVKTRQIWE 310 320 KILGKLLNVC GR
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 V L P S M T K N D L T S I G M L F A H E L L I V A A L T I V N F P F P A N P V R L W I H M D A I I I P F F G Y I V L Q A F C M T P L P I S F L L F V Y F T L A I L I S R F F E S S L L C I L P P V L V A L M T C I A L F G H I S L G M L L Y M P N M C I H S A L D I L G M M V T D S V M I A C Y V I V C T L V I L K A V V S S E A L M A T C N G V N L A K V Y S R N S T I L L L F Y F L I L R E K L I L D L S M Y M P E T K I I A L S A L I T L F R E I S H I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| (R)-(-)-carvone | -2.5 1 | 1.7647 1 | herbal, minty, spearmint, sweet | |
| (S)-(+)-carvone | -2.5 1 | 1.7647 1 | bready, caraway, minty, spicy | |
| butyric acid | - | 0 2 | sharp, acetic, cheesy, buttery, fruity, dairy, creamy | |
| delta-decalactone | - | 0 2 | coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet | |
| diacetyl | - | 0 2 | buttery, caramellic, creamy, pungent, sweet |
1.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.
2.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.