Olfactory Receptor family 51 subfamily A member 4.
Estimated Expression: 84% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MSIINTSYVE ITTFFLVGMP GLEYAHIWIS IPICSMYLIA ILGNGTILFI IKTEPSLHEP MYYFLSMLAM SDLGLSLSSL PTVLSIFLFN APEISSNACF 110 120 130 140 150 160 170 180 190 200 AQEFFIHGFS VLESSVLLIM SFDRFLAIHN PLRYTSILTT VRVAQIGIVF SFKSMLLVLP FPFTLRNLRY CKKNQLSHSY CLHQDVMKLA CSDNRIDVIY 210 220 230 240 250 260 270 280 290 300 GFFGALCLMV DFILIAVSYT LILKTVLGIA SKKEQLKALN TCVSHICAVI IFYLPIINLA VVHRFARHVS PLINVLMANV LLLVPPLTNP IVYCVKTKQI 310 320 RVRVVAKLCQ RKI
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 I L P S A I R N D L T S I E P F L A Y E L L V N F R H V I V D F P F P A N S F I S W I H V N A M V A L F F G Y L V L Q A F C L V T P P I S I L L L N I I P L A G L M S K F F E L S S S C I L P P V L Y F V M L C F S F F G H I L S L G I L Y M P N T I I V A I F D V I G I L V S L D S L I A C Y V I C I H V A I L Q A V V S S E M A L M T G N G V S V C T T Y S R V T T I L L S L F F L I N L A K L I L D F S M Y Y M P T K I I K L Q E L V T L F R E I G H I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| citral | -3.6 1 | (agonist) 1 | sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal | |
| butyric acid | - | 0 2 | sharp, acetic, cheesy, buttery, fruity, dairy, creamy | |
| delta-decalactone | - | 0 2 | coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet | |
| diacetyl | - | 0 2 | buttery, caramellic, creamy, pungent, sweet |
1.) Cong X, Ren W, Pacalon J, Xu R, Xu L, Li X, de March CA, Matsunami H, Yu H, Yu Y, Golebiowski J. Large-Scale G Protein-Coupled Olfactory Receptor-Ligand Pairing. ACS Cent Sci. 2022 Mar 23;8(3):379-387. doi: 10.1021/acscentsci.1c01495. Epub 2022 Feb 18. PMID: 35350604; PMCID: PMC8949627.
2.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR51A4 | 100 | 84% | L | E | I | H | S | V | S | S | S | L | V | F | Y | L | H | Q | G | G | A | L | M | Y | I | A | R | A | N | L | L |
| OR51A2 | 100 | 84% | L | E | I | H | S | V | S | S | S | L | V | F | Y | L | H | Q | G | G | A | L | M | Y | I | A | R | A | N | L | L |
| OR51A7 | 91 | 84% | L | E | I | H | T | V | S | S | S | L | V | F | Y | L | H | Q | G | I | A | T | M | Y | I | A | H | A | D | F | L |
| OR51V1 | 89 | 69% | M | S | I | H | S | F | S | S | S | F | I | P | F | L | H | Q | A | L | V | I | L | Y | I | T | R | G | N | Y | I |
| OR51E1 | 85 | 100% | I | M | I | H | S | G | S | T | G | L | M | L | Y | L | H | Q | G | V | I | A | I | Y | F | S | R | A | N | Y | L |
| OR51Q1 | 84 | 100% | L | F | L | H | S | F | S | S | C | A | V | S | Y | L | H | Q | G | L | A | I | I | Y | M | S | R | A | N | Y | L |
| OR52D1 | 84 | 100% | L | M | V | H | Y | A | S | S | S | I | V | F | Y | E | H | M | G | V | A | A | M | Y | A | F | R | A | N | Y | V |
| OR52E4 | 84 | 88% | L | M | I | H | T | G | T | V | N | L | V | F | Y | E | H | R | G | V | I | I | I | Y | A | F | R | A | N | Y | V |
| OR51E2 | 83 | 96% | L | M | I | H | S | A | S | T | G | F | F | L | Y | V | H | Q | G | A | I | V | M | Y | L | S | R | G | D | Y | L |
| OR52N2 | 82 | 100% | L | M | V | H | T | G | S | G | N | L | I | F | Y | D | H | M | G | V | A | I | G | Y | A | F | R | A | N | Y | L |
| OR51G2 | 82 | 92% | L | L | I | H | S | F | S | S | S | L | I | L | Y | L | H | Q | G | V | I | T | V | Y | M | S | R | G | F | Y | L |
| OR51L1 | 81 | 88% | M | L | I | H | T | F | S | S | S | V | V | T | F | L | H | Q | G | V | V | T | L | F | V | S | R | A | D | Y | L |
| OR51D1 | 80 | 65% | L | M | I | H | S | A | S | A | G | F | F | L | F | L | H | Q | G | I | I | V | M | Y | L | S | R | A | N | Y | L |