Olfactory Receptor family 5 subfamily M member 3.
Sequence:
10 20 30 40 50 60 70 80 90 100 MLNFTDVTEF ILLGLTSRRE WQVLFFIIFL VVYIITMVGN IGMMVLIKVS PQLNNPMYFF LSHLSFVDVW FSSNVTPKML ENLLSDKKTI TYAGCLVQCF 110 120 130 140 150 160 170 180 190 200 FFIALVHVEI FILAAMAFDR YMAIGNPLLY GSKMSRVVCI RLITFPYIYG FLTSLAATLW TYGLYFCGKI EINHFYCADP PLIKMACAGT FVKEYTMIIL 210 220 230 240 250 260 270 280 290 300 AGINFTYSLT VIIISYLFIL IAILRMRSAE GRQKAFSTCG SHLTAVIIFY GTLIFMYLRR PTEESVEQGK MVAVFYTTVI PMLNPMIYSL RNKDVKKAMM 310 KVISRSC
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 W E R R L G A Y T W V F T G R R Q E V S L V Q N E L V L C L T A A Y E K L Y M F M K G I I F F M K P T F F C Q L S T I I M T I L T F V A V V L F V N S A I F L F G Y G A L G Y F I T T Y I I Y V S F W V V H V L I Y P T F N I I V A M P I V V M T D V F F I E F T I L L S Y T L H S P N L G I N G S L H S A A L I R I C I I V T G C T S Y I M V M M L F F F A M V V R S Y S I S F A K L K I L Y M P N M Y R D L I F L Q R G G I A I A I E A S R N R L UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| furaneol | -4 1 | 1.75 1 | sweet, cotton_candy, caramellic, strawberry, brown_sugar | |
| homofuraneol | -4 1 | 1.5 1 | sweet, cotton_candy, burnt_sugar, sugar, caramellic, bready | |
| hexanal | - | 0.5 2 | aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty | |
| 2,2-dimethyl-3(2h)-furanone | - | 0 1 | sweet, rotten_fruit | |
| 2,5-dimethyl-3(2h)-furanone | - | 0 1 | green, bell_pepper | |
| 3-methyl-2(5h)-furanone | - | 0 1 | metallic, solvent |
1.) HAAG, Franziska, HOFFMANN, Sandra, et KRAUTWURST, Dietmar. Key Food Furanones Furaneol and Sotolone Specifically Activate Distinct Odorant Receptors. Journal of Agricultural and Food Chemistry, 2021, vol. 69, no 37, p. 10999-11005.
2.) Ojiro I, Katsuyama H, Kaneko R, Ogasawara S, Murata T, Terada Y, et al. (2024) Enhancement of transcription efficiency by TAR-Tat system increases the functional expression of human olfactory receptors. PLoS ONE 19(6): e0306029. https://doi.org/10.1371/journal.pone.0306029