aldehyde C-6

SMILES:
CCCCCC=O

Aroma Description:
aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty1

Receptor Expression log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
OR2W1 53 -5.1 3, -6.52 8, -4.7 12 10 3, (agonist) 8, 0 11, 8.3 12  sweet, tart, hay, fatty, coumarinic, orange, peony, cinnamon, herbal, tonka
OR1A1 73 -3 12 -  sweet, citrus, fresh, rose, herbal, waxy, orange, spearmint, floral, aldehydic
OR5P3 100 -3.72 12 -  mimosa, hawthorn, spearmint, coumarinic, hay, sweet, acacia, orangeflower, powdery, naphthyl
OR5K1 100 -5 12 0.7 12  hazelnut, nutty, peanut, roasted, carnation, cocoa, almond
OR2J3 100 -4.1 12 1.8 12  tart, hay, sweet, foliage, passionfruit, cinnamon, warm, blackcurrant, coumarinic, candy
OR1G1 61 - 3.0457 2 Ysweet, waxy, citrus, fresh, tart, orange, aldehydic, floral, rose, fatty
OR8B4 61 - 1.5385 7, 0.5 12  hawthorn, mimosa, coumarinic, anise, sweet, vanilla
OR4D11 34 - 1.5 10  sweet, vinegar, sharp, floral, oily, pungent, fatty, sour, fresh, fruity
OR10C1 61 - 0.7 12  lactonic, oily, chemical, sweet, natural, floral, waxy, lemon, fatty, fruity
OR56B1 100 - 0.7 12  dairy, creamy, buttery, milky, lactonic, peach, sharp
OR10H3 57 - 0.6 12  (insufficient data)
OR1J2 100 - 0.5556 9  ozone, cognac, aldehydic, fatty, fresh, peel
OR2B3 42 - 0.5 12  carnation, corn, malty, clove, sweet, pungent, hazelnut, vinegar
OR2Z1 84 - 0.5 12  (insufficient data)
OR4K5 61 - 0.5 12  vetiver, clove, dry
OR5M3 92 - 0.5 12  cotton_candy, brown_sugar, caramellic, maple, burnt_sugar, sugar
OR8B3 88 - 0.5 12  hawthorn, orangeflower, mimosa, neroli, spearmint, coumarinic, anise, sweet, naphthyl, powdery
OR8B8 100 - 0.5 12  caramellic, cilantro, chicken_fat, sweet, vanilla
OR10A2 ? - 0.5 12  (insufficient data)
OR52N4 100 - 0.5 12  sweaty, fatty, leafy, fresh
OR52D1 100 - 0.0508 2  dairy, cheesy, anise, milky, creamy, sour, sharp, peach, lactonic, rancid
OR10J5 84 - 0 3   
OR2C1 100 - 0 3   
OR2J2 92 - 0 3   
OR51E1 100 - 0 3   
OR51L1 88 - 0 3   
OR1A2 19 - 0 4, 0 5   
OR5A1 100 - 0 6   
OR5AN1 100 - 0 6   
OR5I1 46 - 0 7   
OR2M3 100 -3.9 12 -0.5 12 Y 
 

aldehyde C-6

SMILES:
CCCCCC=O

Aroma Description:
aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty

Receptor Expr.% Agonist? Dock Score Known agonist Correlated Perceptual Qualities

Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.

1.) The Good Scents Company

2.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

3.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

4.) Silva Teixeira CS, Silva Ferreira AC, Cerqueira NM. Studying Haloanisoles Interaction with Olfactory Receptors. ACS Chem Neurosci. 2016 Jul 20;7(7):870-85. doi: 10.1021/acschemneuro.5b00335. Epub 2016 May 9. PMID: 27092849.

5.) Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J Struct Biol. 2007 Sep;159(3):400-12. doi: 10.1016/j.jsb.2007.04.013. Epub 2007 May 25. PMID: 17601748.

6.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]

7.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).

8.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

9.) Lim J. H., J. Park, E. H. Oh, H. J. Ko, S. Hong, and Park, T. H. (2014) Nanovesicle-based bioelectronic nose for the diagnosis of lung cancer from human blood. Adv. Healthcare Mater., 3: 360–366.

10.) Cho, S.W., Ko, H.J. & Park, T.H. Identification of a Lung Cancer Biomarker Using a Cancer Cell Line and Screening of Olfactory Receptors for Biomarker Detection. Biotechnol Bioproc E 26, 55–62 (2021).

11.) Franziska Haag, Antonella Di Pizio, Dietmar Krautwurst, The key food odorant receptive range of broadly tuned receptor OR2W1. Food Chemistry 375 (2022) 131680

12.) Ojiro I, Katsuyama H, Kaneko R, Ogasawara S, Murata T, Terada Y, et al. (2024) Enhancement of transcription efficiency by TAR-Tat system increases the functional expression of human olfactory receptors. PLoS ONE 19(6): e0306029. https://doi.org/10.1371/journal.pone.0306029

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