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Olfactory Receptor family 1 subfamily D member 2.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MDGGNQSEGS EFLLLGMSES PEQQRILFWM FLSMYLVTVV GNVLIILAIS SDSRLHTPVY FFLANLSFTD LFFVTNTIPK MLVNLQSHNK AISYAGCLTQ 

       110        120        130        140        150        160        170        180        190        200 
LYFLVSLVAL DNLILAVMAY DRYVAICCPL HYTTAMSPKL CILLLSLCWV LSVLYGLIHT LLMTRVTFCG SRKIHYIFCE MYVLLRMACS NIQINHTVLI 

       210        220        230        240        250        260        270        280        290        300 
ATGCFIFLIP FGFVIISYVL IIRAILRIPS VSKKYKAFST CASHLGAVSL FYGTLCMVYL KPLHTYSVKD SVATVMYAVV TPMMNPFIYS LRNKDMHGAL 

       310        320 
GRLLDKHFKR LT

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

V S D K       H   I Q I N     M L   I A K N      Q L  Q E P S  
 V T A   L P K L   T H N   L T H I   A Y S    N V L    I R Q   
V A Y M   Y V M   A I L V   L G Y   T L C G  M K P I  M W F L  
 P T V   C L T G   C G T   L V S L   Y L Q    T N T    S L F   
P N M M   Y F L   L F I F   V W C   S V L F  V F F L  V L Y M  
 Y I F   S V A G   F P I   L S L L   A V L    D T F    V V T   
      S   L H S   I V F G   L I C   L N D L  S L N A  L V N G  
         A C T S   Y S I   L K P S   A L I    L F F    L I I   
          F A K   I I L V           Y A M V  Y V P T  S S I A  
         Y K K S   I A R             Y R D                 D   
                    I R L           C I A V                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
bourgeonal -7.3 1 10 1  fresh, watery, floral, cyclamen, sweet
(S)-(-)-citronellol -4.51 2 5 2  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
tetrahydromyrcenol -6.2 3 (agonist) 3  fresh, sweet, citrus, lime, floral, lily
floralozone -5.7 1 (agonist) 1  clean, fresh, green, marine, ozone
dihydromyrcenol -5.63 3 (agonist) 3  citrus, clean, cologne, floral, fresh, lime, weedy
citral dimethyl acetal -5.47 3 (agonist) 3  citrus, floral, green, lemon, lime, natural
methyl dihydro isojasmonate -5.43 3 (agonist) 3  green, jasmine, floral, fresh, oily, herbal
oranger crystals -4.67 4 2.0588 4  sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
lilial -5.7 1 0.2129 1  floral, muguet, watery, green, powdery, cumin
(E),(E)-2,4-decadienal -5.18 3 (agonist) 3  oily, cucumber, melon, citrus, pumpkin, nutty, fatty, chicken, fried, chicken_fat, coriander, brothy
gamma-undecalactone -5.14 2 (agonist) 2  fruity, peach, creamy, fatty, lactonic, apricot, ketonic, coconut
myrcenol -5.12 3 (agonist) 3  fresh, floral, lavender, citrus
delta-dodecalactone -5.09 2 (agonist) 2  fresh, sweet, metallic, peach, oily, coconut, buttery, fatty, creamy, dairy, fruity, apricot, milky
coranol -4.96 3 (agonist) 3  bois_de_rose, coriander, floral, rose
zinarine -4.95 3 (agonist) 3  
rosaphen -4.87 3 (agonist) 3  floral, geranium, rose, waxy
benzyl acetone -4.86 3 (agonist) 3  floral, balsamic, strawberry
sulcatone -4.84 3 (agonist) 3  citrus, green, musty, lemongrass, apple, ketonic, creamy, cheesy, banana, vegetable, green_bean
tetrahydrolinalool -4.81 3 (agonist) 3  floral, lily, bois_de_rose, woody, lilac, tea, oily, fatty, citrus_rind
ethyl cinnamate -4.78 3 (agonist) 3  sweet, balsamic, fruity, spicy, powdery, berry, plum, cinnamyl, green
tetrahydrogeraniol -4.78 3 (agonist) 3  leathery, musty, plastic, rose, sweet
1-octyl-2-pyrrolidone -4.76 3 (agonist) 3  
pivarose -4.73 3 (agonist) 3  rose, spicy, red_rose, geranium, blueberry
mefrosol -4.66 3 (agonist) 3  floral, geranium, green, honey, lily, muguet, fresh, rose, tropical
florymoss -4.54 3 (agonist) 3  
citral -4.52 3 (agonist) 3  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
delta-undecalactone -4.52 3 (agonist) 3  creamy, fatty, coconut, fruity, peach, waxy, milky, lactonic, green
methyl cinnamate -4.49 3 (agonist) 3  balsamic, cherry, strawberry, sweet
milk lactone -4.49 3 (agonist) 3  waxy, buttery, oily, creamy, dairy, green, lactonic, plum_skin
(Z)-6-nonen-1-ol -4.48 3 (agonist) 3  cantaloupe, clean, cucumber, fatty, fresh, green, honeydew, juicy, melon, vegetable, waxy
(Z)-5-octen-1-ol -4.48 3 (agonist) 3  earthy, fishy, green, melon, mushroom, soapy, violet_leaf, watermelon, watery
ethyl linalool -4.47 3 (agonist) 3  bergamot, bois_de_rose, fresh, green, herbal, lavender, rose, wet
petiole -4.47 3 (agonist) 3  foliage, green, metallic, plastic, rose, spicy, watercress
1-octen-3-ol -4.38 3 (agonist) 3  mushroom
ethyl cyclohexanecarboxylate - 4 2  cheesy, fruity, winey
benzyl isobutyrate -4.31 3 (agonist) 3  jasmin, oily, fruity, sweet, rose, tropical, powdery, woody, juicy
7-octen-1-ol -4.3 3 (agonist) 3  
phenethyl isovalerate -4.3 3 (agonist) 3  floral, fruity, sweet, rose, peach, apricot, ripe, pineapple, tutti_frutti, apple, blueberry
isojasmone -4.26 3 (agonist) 3  creamy, fatty, floral, fruity, lactonic, spicy, waxy
linalool -4.26 3 (agonist) 3  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
1-nonanol -4.26 3 (agonist) 3  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
gamma-dodecalactone -4.25 2 (agonist) 2  fatty, fruity, metallic, peach, sweet
9-decen-1-ol -4.24 3 (agonist) 3  aldehydic, clean, dewy, floral, fresh, rose, waxy
ethyl p-anisate -4.24 3 (agonist) 3  anisic, cherry, floral, fruity, licorice, powdery, spicy, sweet, tarragon
nerolidyl acetate -4.21 3 (agonist) 3  fresh, sweet, citrus, waxy, freesia, woody
allyl cyclohexylpropionate -4.19 3 (agonist) 3  sweet, pineapple, tropical, fruity, candy, waxy, apple, green
muguet carbinol -4.19 3 (agonist) 3  bois_de_rose, clean, fresh, green, lily, rose, violet
(S)-(-)-citronellal -4.12 3 (agonist) 3  citrus, clean, herbal
jasmatone -4.12 3 (agonist) 3  floral, fruity, jasmine
3-methyl-3-nonanol -4.12 3 (agonist) 3  
benzyl butyrate -4.07 3 (agonist) 3  fresh, fruity, jasmine, apricot, loganberry, sweet, waxy, tropical, pineapple, apple
ethylene glycol monophenoxyacetate -4.06 3 (agonist) 3  
myrac aldehyde -4.02 3 (agonist) 3  aldehydic, citrus, floral, greasy, marine
geraniol -4 3 (agonist) 3  citrus, floral, fruity, rose, sweet, waxy
quintone -3.98 3 (agonist) 3  coconut, foliage, green, herbal, jasmine, oily, rose
geranyl acetate -4 3 0.9405 3  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
benzyl propionate -3.95 3 (agonist) 3  sweet, fruity, floral, banana, jasmin, balsamic, apple, jammy
methyl tuberate -3.95 3 (agonist) 3  waxy, lactonic, metallic, tuberose, plum
benzyl acetate -3.94 3 (agonist) 3  sweet, floral, fruity, jasmine, fresh
beta-methylphenylethylamine -3.91 3 (agonist) 3  animalic
phenethyl acetate -3.91 3 (agonist) 3  floral, fruity, honey, rose, sweet, tropical
delta-tetradecalactone -3.9 3 (agonist) 3  waxy, creamy, buttery, oily, fatty, cheesy, milky, dairy
delta-2-decenolactone -3.86 3 (agonist) 3  sweet, creamy, coconut, lactonic, peach, fruity, herbal
(E)-2-nonenal -3.86 3 (agonist) 3  fatty, green, cucumber, aldehydic, citrus, soapy, melon
3-octyl acetate -3.86 3 (agonist) 3  fresh, bergamot, woody, green, grapefruit, rose, apple, minty, waxy, aldehydic, fatty, citrus, anisic
5-decanol -3.85 3 (agonist) 3  clean, fatty, floral, orange, sweet, watery, waxy
2-heptanone -3.78 3 (agonist) 3  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
citronellyl oxyacetaldehyde -3.77 3 (agonist) 3  aldehydic, floral, fresh, honeysuckle, muguet, sweet, waxy
gamma-decalactone -3.75 2 (agonist) 2  fresh, oily, waxy, peach, coconut, buttery, sweet
7-methylindole -3.75 3 (agonist) 3  
gamma-nonalactone -3.64 2 (agonist) 2  buttery, coconut, creamy, oily, sweet, waxy
phenoxyethyl isobutyrate -3.56 3 (agonist) 3  sweet, fruity, tropical, rose, honey, floral, waxy, green, apple, powdery
5-methylindole -3.53 3 (agonist) 3  
cinnamyl alcohol -3.47 3 (agonist) 3  balsamic, cinnamon, cinnamyl, fermented, floral, green, hyacinth, powdery, spicy, sweet
rosabloom -3.461 5 (agonist) 5  
strawberry glycidate 1 -3.43 3 (agonist) 3  sweet, fruity, strawberry, floral, honey, fatty
anisyl acetate -3.38 3 (agonist) 3  sweet, powdery, balsamic, vanilla, fruity, plum, cherry, tonka, creamy, spicy, coumarinic, licorice
geranyl formate -3.31 3 (agonist) 3  apple, floral, fresh, fruity, green, neroli, peach, rose, tea, tropical
octanal -3.29 3 (agonist) 3  aldehydic, citrus, fatty, green, orange, peel, waxy
neryl acetate -3.25 3 (agonist) 3  citrus, dewy, floral, fruity, grapefruit, pear, rose, soapy, sweet, tropical
delta-nonalactone -3.19 3 (agonist) 3  coconut, creamy, sweet, milky, coumarinic, fatty, oily
delta-tridecalactone -3.14 3 (agonist) 3  buttery, creamy, dairy, milky, musty, oily
geranyl propionate -3.1 3 (agonist) 3  floral, waxy, fruity, rose, tropical, citrus, geranium, powdery, honey, vegetable
acetanisole -3.09 3 (agonist) 3  sweet, hawthorn, anisic, powdery, balsamic, acacia, vanilla, maraschino_cherry, fruity, cherry
tetrahydro citral -3.05 3 (agonist) 3  aldehydic, citrus, green, lemon
delta-decalactone -2.99 2 (agonist) 2  coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet
geranyl butyrate -2.96 3 (agonist) 3  apricot, fresh, fruity, green, peach, raspberry, rose, sweet, tropical, waxy
1-methylindole -2.89 3 (agonist) 3  
heptanal -2.71 3 (agonist) 3  aldehydic, cognac, fatty, fresh, green, herbal, ozone
methyl nicotinate -2.7 3 (agonist) 3  warm, herbal, tobacco
nonanal -1.71 3 (agonist) 3  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
diethyleneglycol hexyl ether -1.52 3 (agonist) 3  
gamma-octalactone - (agonist) 2  sweet, coconut, waxy, creamy, tonka, dairy, fatty
3-octen-2-one - 1 6  earthy, spicy, herbal, sweet, mushroom, hay, blueberry
cinnamyl nitrile - 0 3  cinnamon, cassia, spicy, cumin
citronellyl nitrile - 0 3  citrus, floral, fresh, lemon, metallic, waxy
clonal - 0 3  dry, citrus, orange_peel, metallic, spicy
floridile - 0 3  
frutonile - 0 3  floral, fruity, jasmine, lactonic, peach
hypo-lem - 0 3  citrus, aldehydic, lemon, fatty, metallic
sulfuryl acetate - 0 1  meaty, beef, juice, beefy
undecene-2-nitrile - 0 3  
violet nitrile - 0 3  floral, green, leaf, violet, walnut
undecanal - 0 1 Y 1aldehydic, citrus, cloth, fatty, floral, green, laundered, soapy, waxy

1.) B.L. Cook, D. Steuerwald, L. Kaiser, J. Graveland-Bikker, M. Vanberghem, A.P. Berke, K. Herlihy, H. Pick, H. Vogel, S. Zhang, Large-scale production and study of a synthetic G protein-coupled receptor: Human olfactory receptor 17-4, Proc. Natl. Acad. Sci. USA 106 (2009) 11925-11930

2.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

3.) Veithen, A.; Wilin, F.; Philippeau, M.; Chatelain, P. OR1D2 is a broadly tuned human olfactory receptor. Chem. Senses 2015, 40, 262–263.

4.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.

5.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1

6.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147
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