Olfactory Receptor family 1 subfamily D member 2.
Sequence:
10 20 30 40 50 60 70 80 90 100 MDGGNQSEGS EFLLLGMSES PEQQRILFWM FLSMYLVTVV GNVLIILAIS SDSRLHTPVY FFLANLSFTD LFFVTNTIPK MLVNLQSHNK AISYAGCLTQ 110 120 130 140 150 160 170 180 190 200 LYFLVSLVAL DNLILAVMAY DRYVAICCPL HYTTAMSPKL CILLLSLCWV LSVLYGLIHT LLMTRVTFCG SRKIHYIFCE MYVLLRMACS NIQINHTVLI 210 220 230 240 250 260 270 280 290 300 ATGCFIFLIP FGFVIISYVL IIRAILRIPS VSKKYKAFST CASHLGAVSL FYGTLCMVYL KPLHTYSVKD SVATVMYAVV TPMMNPFIYS LRNKDMHGAL 310 320 GRLLDKHFKR LT
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 Q E P S N V L G A Y S M L I Q I N K K V S Y I R Q M K P I T L C L T H I T H N L Y V M V S D M W F L T N T F Y L Q L G Y A I L V C L T M V T A S L F V F F L S V L L V S L C G T G Y F L V A Y V L Y M D T F L A V L V W C L F I F S V A M P T V V V T S L N A L N D L S L L F P I G L H S P N M L V N G L F F V A L I L I C I V F G A C T S Y I F L I I Y V P T Y A M L K P S Y S I S F A K S S I A V Y R D I I L V Y K K C I A I A R S V S P C R L UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
---|---|---|---|---|
bourgeonal | -7.3 1 | 10 1 | cyclamen, floral, fresh, sweet, watery | |
tetrahydromyrcenol | -6.2 2 | - | citrus, floral, fresh, lily, lime, sweet | |
floralozone | -5.7 1 | - | clean, fresh, green, marine, ozone | |
dihydromyrcenol | -5.63 2 | - | citrus, clean, cologne, floral, fresh, lime, weedy | |
citral dimethyl acetal | -5.47 2 | - | citrus, floral, green, lemon, lime, natural | |
dihydroisojasmonate | -5.43 2 | - | green, jasmine, floral, fresh, oily, herbal | |
(E),(E)-2,4-decadienal | -5.18 2 | - | brothy, chicken, citrus, coriander, cucumber, fat, fatty, fried, melon, nutty, oily, pumpkin | |
gamma-undecalactone | -5.14 2 | - | apricot, coconut, creamy, fatty, fruity, ketonic, lactonic, peach | |
myrcenol | -5.12 2 | - | citrus, floral, fresh, lavender | |
delta-dodecalactone | -5.09 2 | - | buttery, coconut, fresh, metallic, oily, peach, sweet | |
coranol | -4.96 2 | - | bois_de_rose, coriander, floral, rose | |
zinarine | -4.95 2 | - | ||
rosaphen | -4.87 2 | - | floral, geranium, rose, waxy | |
benzyl acetone | -4.86 2 | - | balsamic, floral, strawberry | |
sulcatone | -4.84 2 | - | apple, banana, cheesy, citrus, creamy, fruity, green, ketonic, lemongrass, musty | |
tetrahydrolinalool | -4.81 2 | - | bois_de_rose, citrus, fatty, floral, lilac, lily, oily, rind, rose, tea, woody | |
ethyl cinnamate | -4.78 2 | - | balsamic, berry, cinnamyl, fruity, plum, powdery, spicy, sweet | |
tetrahydrogeraniol | -4.78 2 | - | leathery, musty, plastic, rose, sweet | |
1-octyl-2-pyrrolidone | -4.76 2 | - | ||
pivarose | -4.73 2 | - | blueberry, geranium, red, rose, spicy | |
mefrosol | -4.66 2 | - | floral, geranium, green, honey, lily, muguet, resh, rose, tropical | |
florymoss | -4.54 2 | - | ||
citral | -4.52 2 | - | citrus, lemon, sharp, sweet | |
delta-undecalactone | -4.52 2 | - | coconut, creamy, fatty, fruity, green, lactonic, milky, peach, waxy | |
(S)-(-)-citronellol | -4.51 2 | - | citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy | |
methyl cinnamate | -4.49 2 | - | balsamic, cherry, strawberry, sweet | |
milk lactone | -4.49 2 | - | waxy, buttery, oily, creamy, dairy, green, lactonic, plum_skin | |
cis-6-nonen-1-ol | -4.48 2 | - | cantaloupe, clean, cucumber, fatty, fresh, green, honeydew, juicy, melon, vegetable, waxy | |
cis-5-octen-1-ol | -4.48 2 | - | earthy, fishy, green, melon, mushroom, soapy, violet_leaf, watermelon, watery | |
ethyl linalool | -4.47 2 | - | bergamot, bois_de_rose, fresh, green, herbal, lavender, rose, wet | |
petiole | -4.47 2 | - | foliage, green, metallic, plastic, rose, spicy, watercress | |
1-octen-3-ol | -4.38 2 | - | mushroom | |
benzyl isobutyrate | -4.31 2 | - | fruity, jasmine, juicy, oily, powdery, rose, sweet, tropical, woody | |
7-octen-1-ol | -4.3 2 | - | ||
phenethyl isovalerate | -4.3 2 | - | apple, apricot, blueberry, floral, fruity, frutti, peach, pineapple, ripe, rose, sweet, tutti | |
isojasmone | -4.26 2 | - | creamy, fatty, floral, fruity, lactonic, spicy, waxy | |
linalool | -4.26 2 | - | blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody | |
1-nonanol | -4.26 2 | - | aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet | |
gamma-dodecalactone | -4.25 2 | - | fatty, fruity, metallic, peach, sweet | |
9-decen-1-ol | -4.24 2 | - | aldehydic, clean, dewy, floral, fresh, rose, waxy | |
ethyl p-anisate | -4.24 2 | - | anisic, cherry, floral, fruity, licorice, powdery, spicy, sweet, tarragon | |
nerolidyl acetate | -4.21 2 | - | citrus, freesia, fresh, sweet, waxy, woody | |
allyl cyclohexylpropionate | -4.19 2 | - | apple, candy, fruity, green, pineapple, sweet, tropical, waxy | |
muguet carbinol | -4.19 2 | - | bois_de_rose, clean, fresh, green, lily, rose, violet | |
(S)-(-)-citronellal | -4.12 2 | - | citrus, clean, herbal | |
jasmatone | -4.12 2 | - | floral, fruity, jasmine | |
3-methyl-3-nonanol | -4.12 2 | - | ||
benzyl butyrate | -4.07 2 | - | apple, apricot, fresh, fruity, jasmine, loganberry, pineapple, sweet, tropical, waxy | |
ethylene glycol monophenoxyacetate | -4.06 2 | - | ||
myrac aldehyde | -4.02 2 | - | aldehydic, citrus, floral, greasy, marine | |
geraniol | -4 2 | - | citrus, floral, fruity, rose, sweet, waxy | |
quintone | -3.98 2 | - | coconut, foliage, green, herbal, jasmine, oily, rose | |
benzyl propionate | -3.95 2 | - | apple, balsamic, banana, floral, fruity, jammy, jasmine, sweet | |
methyl tuberate | -3.95 2 | - | lactonic, metallic, plum, tuberose, waxy | |
benzyl acetate | -3.94 2 | - | floral, fresh, fruity, jasmine, sweet | |
beta-methylphenylethylamine | -3.91 2 | - | animalic | |
phenethyl acetate | -3.91 2 | - | floral, fruity, honey, rose, sweet, tropical | |
delta-tetradecalactone | -3.9 2 | - | buttery, cheesy, creamy, dairy, fatty, milky, oily, waxy | |
delta-2-decenolactone | -3.86 2 | - | sweet, creamy, coconut, lactonic, peach, fruity, herbal | |
(E)-2-nonenal | -3.86 2 | - | aldehydic, citrus, cucumber, fatty, green | |
3-octyl acetate | -3.86 2 | - | aldehydic, anisic, apple, bergamot, citrus, fatty, fresh, grapefruit, green, minty, rose, waxy, woody | |
5-decanol | -3.85 2 | - | clean, fatty, floral, orange, sweet, watery, waxy | |
2-heptanone | -3.78 2 | - | banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody | |
citronellyl oxyacetaldehyde | -3.77 2 | - | aldehydic, floral, fresh, honeysuckle, muguet, sweet, waxy | |
gamma-decalactone | -3.75 2 | - | buttery, coconut, fresh, oily, peach, sweet, waxy | |
7-methylindole | -3.75 2 | - | ||
gamma-nonalactone | -3.64 2 | - | buttery, coconut, creamy, oily, sweet, waxy | |
phenirate | -3.56 2 | - | floral, fruity, honey, rose, sweet, tropical, waxy | |
5-methylindole | -3.53 2 | - | ||
cinnamyl alcohol | -3.47 2 | - | balsamic, cinnamon, cinnamyl, fermented, floral, green, hyacinth, powdery, spicy, sweet | |
strawberry glycidate | -3.43 2 | - | cherry, fruity, grape, jammy, phenolic, strawberry, sweet | |
anisyl acetate | -3.38 2 | - | balsamic, cherry, fruity, plum, powdery, sweet, tonka, vanilla | |
geranyl formate | -3.31 2 | - | apple, floral, fresh, fruity, green, neroli, peach, rose, tea, tropical | |
aldehyde C-8 | -3.29 2 | - | aldehydic, citrus, fatty, green, orange, peel, waxy | |
neryl acetate | -3.25 2 | - | citrus, dewy, floral, fruity, grapefruit, pear, rose, soapy, sweet, tropical | |
delta-nonalactone | -3.19 2 | - | coconut, coumarinic, creamy, fatty, milky, oily, sweet | |
delta-tridecalactone | -3.14 2 | - | buttery, creamy, dairy, milky, musty, oily | |
geranyl propionate | -3.1 2 | - | floral, fresh, fruity, honey, powdery, rose, tropical, vegetable, waxy | |
acetanisole | -3.09 2 | - | acacia, anisic, balsamic, cherry, hawthorn, maraschino_cherry, powdery, sweet, vanilla | |
tetrahydro citral | -3.05 2 | - | aldehydic, citrus, green, lemon | |
delta-decalactone | -2.99 2 | - | coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet | |
oranger crystals | -4.67 2 | 2.0588 3 | honey, neroli, orangeflower, powdery, sweet | |
geranyl butyrate | -2.96 2 | - | apricot, fresh, fruity, green, peach, raspberry, rose, sweet, tropical, waxy | |
lilial | -5.7 1 | 0.2129 4 | cumin, floral, green, muguet, powdery, watery | |
1-methylindole | -2.89 2 | - | ||
heptanal | -2.71 2 | - | aldehydic, cognac, fatty, fresh, green, herbal, ozone | |
methyl nicotinate | -2.7 2 | - | herbal, tobacco, warm | |
geranyl acetate | -4 4 | 0.9405 4 | floral, green, lavender, rose, waxy | |
aldehyde C-9 | -1.71 2 | - | aldehydic, fatty, fresh, orange, orris, peel, peely, rose, waxy | |
diethyleneglycol hexyl ether | -1.52 2 | - | ||
3-octen-2-one | - | 1 5 | earthy, spicy, herbal, sweet, mushroom, hay, blueberry | |
cinnamyl nitrile | - | 0 2 | cassia, cinnamon, cumin, spicy | |
citronellyl nitrile | - | 0 2 | citrus, floral, fresh, lemon, metallic, waxy | |
clonal | - | 0 2 | citrus, dry, metallic, orange, peel, spicy | |
floridile | - | 0 2 | ||
frutonile | - | 0 2 | floral, fruity, jasmine, lactonic, peach | |
hypo-lem | - | 0 2 | aldehydic, citrus, fatty, lemon, metallic | |
sulfuryl acetate | - | 0 1 | meaty, beef, juice, beefy | |
undecanal | - | 0 1 | Y | aldehydic, citrus, cloth, fatty, floral, green, laundered, soapy, waxy |
undecene-2-nitrile | - | 0 2 | ||
violet nitrile | - | 0 2 | floral, green, leaf, violet, walnut |
1.) B.L. Cook, D. Steuerwald, L. Kaiser, J. Graveland-Bikker, M. Vanberghem, A.P. Berke, K. Herlihy, H. Pick, H. Vogel, S. Zhang, Large-scale production and study of a synthetic G protein-coupled receptor: Human olfactory receptor 17-4, Proc. Natl. Acad. Sci. USA 106 (2009) 11925-11930
2.) Veithen, A.; Wilin, F.; Philippeau, M.; Chatelain, P. OR1D2 is a broadly tuned human olfactory receptor. Chem. Senses 2015, 40, 262–263.
3.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.
4.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
5.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147