Olfactory Receptor family 7 subfamily A member 5.
Estimated Expression: 100% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MEPGNDTQIS EFLLLGFSQE PGLQPFLFGL FLSMYLVTVL GNLLIILATI SDSHLHTPMY FFLSNLSFAD ICVTSTTIPK MLMNIQTQNK VITYIACLMQ 110 120 130 140 150 160 170 180 190 200 MYFFILFAGF ENFLLSVMAY DRFVAICHPL HYMVIMNPHL CGLLVLASWT MSALYSLLQI LMVVRLSFCT ALEIPHFFCE LNQVIQLACS DSFLNHMVIY 210 220 230 240 250 260 270 280 290 300 FTVALLGGGP LTGILYSYSK IISSIHAISS AQGKYKAFST CASHLSVVSL FYGAILGVYL SSAATRNSHS SATASVMYTV VTPMLNPFIY SLRNKDIKRA 310 320 LGIHLLWGTM KGQFFKKCP
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 S S H S L Y V L F S D V M T I V K Q I L G P E A T A G L I M H N L I Q L A I Y N M L F P Q Y M V S A G Y F F Y I V L S Y Q M L C M K P I L G F L V V T L S V A V T L A S M F Y M T T S S L F L M P T V S L H G G L L T W S F L I F T V C I V L Y M F P N S A C L P G A L V L F G A D A F L V T L S Y I T S F A L I G T L G C L F N E S L N S L L N G R K Y K Y S Y L H P N V S L L F F L I I G Q A S I I K S D Y A M Y M P T S I T A I S S V F R D I A H H C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| myrac aldehyde | - | 8.3333 1 | aldehydic, citrus, floral, greasy, marine | |
| rotundone | -5.25 2 | 6 2 | woody, peppery, agarwood, spicy, guaiacwood | |
| furaneol | - | 6 3 | sweet, cotton_candy, caramellic, strawberry, brown_sugar | |
| beta-damascenone | - | 0 3 | natural, sweet, fruity, rose, plum, grape, raspberry, sugar, woody, earthy, green, floral | |
| beta-ionone | - | 0 3 | beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent | |
| 1-octen-3-one | - | 0 3 | earthy, metallic, mushroom | |
| phenylacetic acid | - | 0 3 | sweet, honey, floral, honeysuckle, sour, waxy, civet | |
| sotolone | - | 0 3 | sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy |
1.) Veitinger T, Riffell JR, Veitinger S, Nascimento JM, Triller A, Chandsawangbhuwana C, Schwane K, Geerts A, Wunder F, Berns MW, Neuhaus EM, Zimmer RK, Spehr M, Hatt H. Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm. J Biol Chem. 2011 May 13;286(19):17311-25. doi: 10.1074/jbc.M110.211524. Epub 2011 Mar 21. PMID: 21454470; PMCID: PMC3089573.
2.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1
3.) Hartmann C, Triller A, Spehr M, Dittrich R, Hatt H, Buettner A. Sperm-Activating Odorous Substances in Human Follicular Fluid and Vaginal Secretion: Identification by Gas Chromatography–Olfactometry and Ca2 Imaging. Chempluschem 78: 695–702, 2013. doi:10.1002/cplu.201300008
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR7A5 | 100 | 100% | V | M | F | I | A | G | N | F | S | Y | S | Q | F | E | L | N | I | T | V | L | G | Y | I | Y | S | S | V | Y | T |
| OR7A10 | 91 | 73% | F | M | F | L | V | G | N | F | S | N | S | Q | F | E | I | N | M | A | V | L | G | Y | C | Y | S | S | V | Y | T |
| OR7A2 | 87 | F | M | F | V | I | V | S | L | S | N | S | Q | F | E | L | N | M | A | A | L | D | Y | G | Y | S | S | V | Y | T | |
| OR7A17 | 86 | 100% | F | M | F | V | G | G | S | L | A | N | S | Q | F | E | L | N | M | A | A | L | A | C | G | Y | S | S | V | Y | T |
| OR7C2 | 86 | 53% | F | I | F | I | G | C | N | L | S | G | S | E | F | D | P | S | M | V | T | L | G | Y | G | Y | S | S | V | Y | T |
| OR1K1 | 85 | 100% | F | M | F | F | G | V | S | C | S | H | S | Y | F | D | H | Q | I | E | G | V | V | Y | V | Y | T | T | V | Y | T |
| OR7E24 | 84 | 96% | F | M | F | V | A | C | D | M | S | D | S | H | F | D | P | S | I | M | G | F | G | Y | G | Y | S | S | V | Y | T |
| OR10R2 | 84 | 57% | Y | M | F | L | A | I | C | L | G | A | S | V | F | D | I | S | I | C | G | V | L | Y | A | Y | T | T | V | Y | T |
| OR1B1 | 84 | 100% | L | F | F | Y | G | V | T | L | S | H | T | R | F | D | H | R | I | E | G | L | M | Y | I | Y | P | S | V | Y | T |
| OR10K1 | 84 | 100% | Y | M | F | L | G | S | S | F | G | V | S | T | F | D | I | S | I | L | G | A | L | Y | A | Y | K | S | V | Y | T |
| OR8H1 | 82 | 88% | Y | M | F | V | G | A | C | F | S | N | S | N | F | D | T | S | I | L | A | T | L | Y | M | Y | R | S | V | Y | T |
| OR1L3 | 80 | 100% | Y | M | F | L | G | N | S | Y | S | H | S | H | F | D | V | N | A | E | G | S | V | Y | I | Y | L | T | I | Y | T |
| OR2D3 | 80 | 100% | F | I | F | L | G | C | C | A | G | V | S | D | F | E | P | P | I | M | G | I | L | Y | G | Y | N | S | V | Y | T |
| OR1C1 | 80 | 100% | F | L | F | V | V | N | S | L | T | H | A | H | F | D | L | N | I | V | G | L | A | Y | A | Y | S | T | I | Y | S |
| OR2V1 | 80 | L | I | F | V | V | G | G | L | G | D | G | Q | F | E | V | Q | L | C | C | M | L | Y | A | Y | R | S | I | Y | T | |
| OR1Q1 | 80 | 100% | F | T | F | I | A | V | N | F | S | H | A | H | F | D | L | Y | I | E | G | V | I | Y | L | Y | L | T | V | Y | T |