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Olfactory Receptor family 8 subfamily H member 1.

Estimated Expression: 88% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MGRRNNTNVP DFILTGLSDS EEVQMALFIL FLLIYLITML GNVGMILIIR LDLQLHTPMY FFLTHLSFID LSYSTVITPK TLANLLTSNY ISFMGCFAQM 

       110        120        130        140        150        160        170        180        190        200 
FFFVFLGAAE CFLLSSMAYD RYVAICSPLR YPVIMSKRLC CALVTGPYVI SFINSFVNVV WMSRLHFCDS NVVRHFFCDT SPILALSCMD TYDIEIMIHI 

       210        220        230        240        250        260        270        280        290        300 
LAGSTLMVSL ITISASYVSI LSTILKINST SGKQKALSTC ASHLLGVTIF YGTMIFTYLK PRKSYSLGRD QVASVFYTIV IPMLNPLIYS LRNKEVKNAL 

       310        320 
IRVMQRRQDS R

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

R G L S  L Y T F  D Y T D     M W   S I Y N      L L  V E E S  
 V Q D    I M T    I E I   V V N V   G M F    N A L    A M Q   
F V S A  G Y F I  I H I M   F S N   Q A F C  T K P T  L I F L  
 I T Y    T V G    G A L   I F S I   F F M    I V T    L L F   
M P I V  L L H S  M L T S   V Y P   L F V F  S Y S L  I L Y I  
 P N L    A C T    L S V   G T V L   A A G    D I F    L M T   
S Y I L  S L A K  S I T I   A C C   L F C E  S L H T  G V N G  
          Q K G    Y S A   L R K S   S S L    L F F    L I M   
         S T S N  L I S V           D Y A M  Y M P T  L R I I  
                   I T S             V Y R                 D   
                    I K L             C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
peony acetonitrile -5.23 1 10 1  peony, floral, geranium, grapefruit, fresh
vanillin -5.1 2 (agonist) 2  chocolate, creamy, sweet, vanilla
skatole -4.22 3 1.9512 3  animal, civet, fecal, naphthyl
1,1,6-trimethyl-1,2-dihydronaphthalene -4.49 4 1.5 4  petrol
4-vinylguaiacol -4.3 5 0.4 5  spicy, clove, carnation, phenolic, peppery, smoky, woody, powdery
indole -4.22 3 0.1626 3  animal, fecal, floral, naphthyl
oranger crystals -3.8 6 0.6471 6  sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
(R)-(-)-carvone -3.5 6 0.5294 6  herbal, minty, spearmint, sweet
allyl cyclohexylpropionate - -0.1626 3  sweet, pineapple, tropical, fruity, candy, waxy, apple, green
delta-damascone - -0.1626 3  fruity, sweet, rose, natural, petal, currant_bud, black_currant_bud, tobacco
(-)-alpha-fenchol - -0.1626 3  camphorous, clean, cooling, eucalyptus, green, herbal, minty, piney, woody
hydroxycitronellal - -0.1626 3  floral, green, lily, melon, sweet, tropical, waxy
(Z)-jasmone - -0.1626 3  woody, herbal, floral, spicy, jasmine, celery
labienoxime - -0.1626 3  currant_bud, blackcurrant_bud, green, grapefruit, herbal, rose, sage
lilial - -0.1626 3  floral, muguet, watery, green, powdery, cumin
melafleur - -0.1626 3  floral, clean, muguet, ozone, marine, sandy, balsamic
7-methoxycitronellal - -0.1626 3  fresh, melon, floral, lily, sweet
muscenone - -0.1626 3  animal, musk, soapy
myrac aldehyde - -0.1626 3  aldehydic, citrus, floral, greasy, marine
myraldyl acetate - -0.1626 3  fresh, lily, magnolia, sweet, citrus, freesia, green
thymol - -0.1626 3  camphorous, herbal, medicinal, phenolic, thyme
triplal - -0.1626 3  green, aldehydic, leafy, cortex, tart, floral, peely
alpha,alpha-dimethyl phenethyl acetate - -0.4065 3  sweet, floral, fruity, rose, green, pear, berry, jasmin, powdery
civetone - -0.4065 3  clean, musk, dry, animal, sweet
cyclamen homoaldehyde - -0.4065 3  floral, muguet, lily, green, tropical, oily, greasy, marine, balsamic
ebanol - -0.4065 3  sandalwood, woody, musk
ethyl linalyl ether - -0.4065 3  floral
geraniol - -0.4065 3  citrus, floral, fruity, rose, sweet, waxy
grapefruit pentanol - -0.4065 3  vetiver, green, citrus, grapefruit, rhubarb, floral
methyl ionone gamma - -0.4065 3  violet, sweet, orris, powdery, floral, woody
methyl jasmonate - -0.4065 3  jasmin, floral, oily, green, petal, greasy, soft
perillic aldehyde - -0.4065 3  fresh, green, herbal, grassy, sweet, minty, cumin, spicy, citrus
3-(3-propen-2-yl phenyl) butanal - -0.4065 3  ozone, cortex, green, floral, melon
strawberry glycidate 1 - -0.4065 3  sweet, fruity, strawberry, floral, honey, fatty
gamma-undecalactone - -0.4065 3  fruity, peach, creamy, fatty, lactonic, apricot, ketonic, coconut
verdyl acetate - -0.4065 3  floral, green, soapy, cedar, pine, woody
amber butanol - -0.6504 3  woody, amber, ambrette
(-)-ambroxide - -0.6504 3  dry, amber, ambergris, paper, musk, woody, cedar, pine, green, seedy
exaltolide - -0.6504 3  animal, fruity, musk, natural, powdery
galaxolide - -0.6504 3  floral, musk, sweet
galbascone - -0.6504 3  fresh, green, galbanum, earthy, weedy, pineapple, narcissus, hyacinth, fruity
beta-ionone - -0.6504 3  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
(R,S)-methyl cedryl ketone - -0.6504 3  woody, vetiver, amber, leathery, musk, cedar
patchouli hexanol - -0.6504 3  woody, musty, patchouli, camphorous, minty, leathery
spicy carbonate - -0.6504 3  spicy, woody, floral, green, herbal
tetrahydrogeraniol - -0.6504 3  leathery, musty, plastic, rose, sweet

1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

2.) https://doi.org/10.1038/s41598-025-17996-x

3.) Aya Kato, Naoko Saito (2015) Odor control agent. JP5798382B2

4.) Franziska Haag, Tim Frey, Lena Ball, Sandra Hoffmann, and Dietmar Krautwurst Petrol Note in Riesling − 1,1,6-Trimethyl-1,2-dihydronaphthalene (TDN) Selectively Activates Human Odorant Receptor OR8H1 Journal of Agricultural and Food Chemistry virtual special issue "13th Wartburg Symposium on Flavor Chemistry and Biology" (2024) https://doi.org/10.1021/acs.jafc.3c08230

5.) Aya Namba, Naoko Saito, Keiichi Yoshikawa, Ichiro Mori (2015) Search method of urine odor suppressor JP2015211667A

6.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.
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