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Olfactory Receptor family 1 subfamily C member 1.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MEKRNLTVVR EFVLLGLPSS AEQQHLLSVL FLCMYLATTL GNMLIIATIG FDSHLHSPMY FFLSNLAFVD ICFTSTTVPQ MVVNILTGTK TISFAGCLTQ 

       110        120        130        140        150        160        170        180        190        200 
LFFFVSFVNM DSLLLCVMAY DRYVAICHPL HYTARMNLCL CVQLVAGLWL VTYLHALLHT VLIAQLSFCA SNIIHHFFCD LNPLLQLSCS DVSFNVMIIF 

       210        220        230        240        250        260        270        280        290        300 
AVGGLLALTP LVCILVSYGL IFSTVLKITS TQGKQRAVST CSCHLSVVVL FYGTAIAVYF SPSSPHMPES DTLSTIMYSM VAPMLNPFIY TLRNRDMKRG 

       310        320 
LQKMLLKCTV FQQQ

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

S E P M       S   F S V D     I L   I T K T      L I  Q E A S  
 L T D   S P S F   M V N   V T H L   A F S    N V V    L H Q   
M I T S   Y V A   A F I I   L A H   T L C G  M Q P V  L V S L  
 M S Y   I A T G   G G V   L Y T V   F L Q    T T S    C L F   
M P A V   Y F L   L A L L   L W L   S V F F  T F C I  A L Y M  
 P N L   V V V S   L P T   G A V L   N V F    D V F    L T T   
    I F   L H C   L I C V   Q V C   L S D M  A L N S  L M N G  
         S C T S   Y S V   L C L N   C L L    L F F    A I I   
          V A R   F I L G           Y A M V  Y M P S  F G I T  
         Q K G Q   V T S             Y R D                 D   
                    I K L           C I A V                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB 2
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
linalool -7.86 1 10 1  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
coumarin -6 2 2.6667 2  coumarinic, hay, sweet, tonka
pelargonic acid - 2.3333 2  cheesy, dairy, dirty, waxy
androstenone - 1 2  animal, musky
allyl phenylacetate - 0 2  honey, fruity, rummy
n-amyl alcohol - 0 2  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
amyl hexanoate - 0 2  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
l-arabinose - 0 2  
benzene - 0 2  gasoline, phenolic, solvent, cinnamon
butyl formate - 0 2  fruity, plum, rummy, brandy
butyric acid - 0 2  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
(S)-(+)-carvone - 0 2  bready, caraway, minty, spicy
citral - 0 2  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
coffee difuran - 0 2  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
beta-damascone - 0 2  berry, currant, floral, fruity, honey, plum, rose, tobacco
decanal - 0 2  sweet, aldehydic, waxy, orange_peel, citrus, floral
dimethyl disulfide - 0 2  sulfurous, vegetable, cabbage, onion, malty, creamy
2,4-DNT - 0 2  
2-ethyl fenchol - 0 2  camphorous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl vanillin - 0 2  sweet, creamy, vanilla, caramellic
eugenol - 0 2  clove, spicy, sweet, woody
eugenyl acetate - 0 2  carnation, clove, floral, fresh, malty, spicy, sweet, woody
helional - 0 2  cyclamen, fresh, green, hay, ozone, watery
2-heptanone - 0 2  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
(Z)-3-hexen-1-ol - 0 2  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
isobutylamine - 0 2  cheesy, fishy
d-limonene - 0 2  citrus, orange, fresh, sweet
lyral - 0 2  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
(1S,2R,5S)-(+)-menthol - 0 2  cooling, mentholic, minty
methyl eugenol - 0 2  carnation, cinnamon, clove, fresh, spicy, sweet, warm
methyl furfuryl disulfide - 0 2  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
methyl salicylate - 0 2  minty, wintergreen
nonanal - 0 2  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
octanethiol - 0 2  sulfurous
1-octanol - 0 2  aldehydic, green, mushroom, orange, rose, waxy
octyl octanoate - 0 2  coconut, oily, fruity
propanal - 0 2  alcoholic, cocoa, earthy, nutty, whisky, winey
propionic acid - 0 2  acidic, cheesy, pungent, vinegar
pyrazine - 0 2  pungent, sweet, corn, roasted, hazelnut, barley
quinoline - 0 2  earthy, medicinal, musty, rubbery, tobacco
terpinyl acetate - 0 2  bergamot, citrus, herbal, lavender, lime

1.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1

2.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
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